1/4 Powering Genetic Discovery for Severe Mental Illness in Latin American and African Ancestries

1/4 推动拉丁美洲和非洲血统中严重精神疾病的基因发现

• 批准号: 10818964
• 负责人: Alicia Martin
• 金额: $ 99.85万
• 依托单位: BROAD INSTITUTE, INC.
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-14 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10818964
• 关键词: Acceleration; Administrative Supplement; African; African ancestry; Anhedonia; Asian; Awareness; Bipolar Disorder; Cognition; Communities; Consensus; Country; Data; Data Analyses; Data Analytics; Data Collection; Deposition; Diagnosis; Dimensions; Discrimination; Disease; Environment; Equity; Ethics; Future; Genetic; Genetic Research; Genetic study; Goals; Healthcare Systems; Heritability; Individual; Kenya; Latin American; Measurement; Measures; Mental Health; Mental disorders; Methodology; National Institute of Mental Health; Obsessive compulsive behavior; Phenotype; Population; Population Heterogeneity; Procedures; Process; Property; Psychometrics; Reproducibility; Resources; Schizophrenia; Site; Standardization; Symptoms; Testing; Training Activity; Uganda; Underrepresented Populations; cognitive function; cohort; data archive; disease phenotype; innovation; instrument; member; phenotypic data; psychogenetics; severe mental illness; simulation; skills; social stigma; suicidal; trait; working group

PROJECT SUMMARY This project actualizes a primary goal of the Ancestral Populations Network (APN; PAR-20-026 and PAR-20- 027), namely to facilitate measurement and data analytic harmonization efforts across APN members to enhance rigor and reproducibility and generate a resource for network members and the scientific community. Through a consensus process of APN members, measures of anhedonia, cognition, obsessive-compulsive symptoms, suicidality, and discrimination/stigma were selected for harmonization across ongoing studies. These harmonized measures will be collected across an estimated 27,500 individuals representing Asian, Latin American, and African ancestries spanning over 15 countries.

项目摘要 该项目实现了祖先人口网络（APN; PAR-20-026和PAR-20- 027）的一个主要目标。 027），即促进APN成员之间的测量和数据分析协调工作， 严谨性和可重复性，并为网络成员和科学界提供资源。通过 APN成员的共识过程，快感缺乏，认知，强迫症状， 自杀倾向和歧视/污名被选择用于协调正在进行的研究。这些 将在代表亚洲、拉丁美洲和加勒比地区的大约27，500名个人中收集统一的测量结果， 美国和非洲血统跨越15个国家。