The relationship between fMRI and patient-reported outcomes in chemotherapy-induced neuropathy:  A diversity supplement

功能磁共振成像与化疗引起的神经病变患者报告结果之间的关系：多样性补充

• 批准号: 10819004
• 负责人: Constance Margaret Johnson
• 金额: $ 19.79万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10819004
• 关键词: Acupressure; Anti-Inflammatory Agents; Attitude; Brain Injuries; Brief Pain Inventory; Cancer Patient; Cellular Phone; Clinical; Clinical Trials Design; Data; Data Analyses; Development; Dose; Ear; Educational process of instructing; Faculty; Foundations; Functional Magnetic Resonance Imaging; Goals; Individual; Manuscripts; Mentors; Modality; Nonpharmacologic Therapy; Pain; Participant; Patient Outcomes Assessments; Quality of life; Questionnaires; Research; Research Personnel; Resources; Scientist; Secure; Self Management; Sensory; Signal Transduction; Symptoms; Testing; Training; career; chemotherapy induced neuropathy; cytokine; data management; experience; follow-up; imaging biomarker; imaging study; improved; innovation; mobile application; opioid use; pain relief; parent grant; participant retention; recruit; side effect; treatment duration

Summary of Parent Grant (R01CA245054) Chemotherapy induced neuropathy (CIN) is a severe side effect that impacts greater than 60% of cancer patients. CIN impacts treatment duration and dosing, functional mobility, and quality of life. This proposal examines the effect of auricular point acupressure (APA) as an innovated solution for CIN. APA utilizes a non-invasive, active modality of treatment stimulating points on ear to improve CIN symptoms. Utilizing a mobile application on smartphones, this project teaches participants how to stimulate their ears for three minutes, 3 times a day to alleviate pain. Given limited understanding of the mechanism of pain relief, participants will complete multiple questionnaires: Quantitative Sensory Test, Revised Brief Pain Inventory-CIN, PROMIS- 29, Opioid Use, Experience and Attitude, and Demographic data. Additionally, imaging studies and biomarkers will be obtained. Functional MRI (fMRIs) will obtain pre-, post-, and follow-up APA evoked signal changes and pro- and anti- inflammatory cytokines will be collected. The goal of this study is to ascertain the efficacy of APA as a self-managed, adjunctive therapy to enhance CIN management, through understanding the underlying mechanisms of APA on CIN.

家长补助金摘要（R01CA245054）