TMJ SYMPHONY Systems-integrated model and mechanisms of patient-centered holistic outcomes and network-supported training and therapy
TMJ SYMPHONY 系统集成模型和以患者为中心的整体结果机制以及网络支持的培训和治疗
基本信息
- 批准号:10829112
- 负责人:
- 金额:$ 38.44万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-14 至 2024-09-13
- 项目状态:已结题
- 来源:
- 关键词:AccelerationAddressAdvocacyAffectAnimal ModelAreaArthralgiaArtificial IntelligenceAttentionBasic ScienceBehaviorBig DataBiologicalBiological MarkersBiological Specimen BanksBiomechanicsCalibrationCaringCell modelClinicalClinical ProtocolsClinical ResearchClinical TrialsClinical Trials NetworkComplexComputer ModelsDataDevelopmentDiseaseE-learningEngineeringEnvironmental ImpactEtiologyEvidence based treatmentExtramural ActivitiesFellowship ProgramFosteringFutureGenderGoalsGrantGuidelinesHealthHealthcareIncubatorsIndividualIndustryInformation SystemsInfrastructureInstitutionKnowledgeLearningMachine LearningMedicineMethodsModalityModelingMulti-site clinical studyNational Institute of Dental and Craniofacial ResearchOutcomeOutcome AssessmentPainPain MeasurementParticipantPatientsPerceptionPersonsPhasePhenotypePopulationRegistriesReportingResearchResearch PersonnelResearch TrainingResourcesScientistSiteSpecialistStructureSystemTalentsTechniquesTechnologyTelemedicineTemporomandibular JointTemporomandibular Joint DisordersTherapeuticTissue EngineeringTrainingTraining SupportTraining and EducationTranslationsUnited StatesUnited States National Academy of SciencesVisionWomancareer developmentclinical careclinical centerclinical phenotypeclinical research sitecombinatorialdata repositorydata-driven modeldesigndisease diagnosisexperiencehuman modelimproved outcomeindividualized medicineinnovationinteroperabilityjoint destructionmeetingsmenmind/bodymultidisciplinarymultimodal datamultimodalitynext generationnovel strategiesoptimismpatient orientedpatient populationpre-clinicalpreventprogramspsychosocialsocial determinantsstem cell therapysupport networktreatment comparison
项目摘要
PROJECT SUMMARY
Approximately 35 million people in the United States are affected by temporomandibular disorders (TMDs) with
women 3-8 times more likely to seek treatment compared to men, making it a highly prevalent and expensive
healthcare challenge demanding immediate attention. Identifying a specific and treatable cause for TMD is
difficult, as it is caused by complex, multifaceted interactions involving biomechanical, biological, and
psychosocial components that are poorly understood. Due to these significant gaps in knowledge and the limited
integrated mechanistic understanding of TMD, successful long-term therapeutic approaches and patient-specific
guidelines to treatment are not available. Our proposal, TMJ SYMPHONY: Systems-integrated model and
mechanisms of patient-centered holistic outcomes and network-supported training and therapy, will strategically
coalesce a multidisciplinary and multiscale national consortium to decipher the relationships between
temporomandibular joint (TMJ) structure-function-pain using computational, cellular, animal and human models.
This collective of talented investigators will build upon an existing MPI U01 focused on healthy TMJ structure-
function between intramural NIDCR Clinical Researchers and extramural Basic Scientists. It will leverage existing
national resources (e.g. RE-JOIN, OPPERA, DOCTRC) to accelerate the translation of discoveries and
technologies to directly address TMJ disease diagnosis (e.g., multimodality deep phenotyping, biomarkers), the
spectrum of healthy TMJ to preclinical TMJ disease to TMJ degeneration/pain, treatment (e.g., non-invasive
holistic/conservative therapies, stem cell therapy, tissue engineered constructs), and improve outcome
assessment by understanding patient adaptive capabilities, mind-body-TMJ connection and environmental
impact on behavior and perception, and social determinants of TMJ health/disease in a diverse patient
population. In this planning phase, we will strategize to make dramatic progress in mechanistic knowledge and
identifying combinatorial etiology, while expanding care options, providing evidence-based treatment decisions,
and patient-specific treatment modalities over the next decade. What justifies our optimism are our new
approaches and techniques already in progress (e.g. chair-side TMJ structure-function-pain assessment toolkit
and deep clinical phenotyping, TMJ omics, multi-modality data driven models) and the enthusiasm of clinicians
and researchers alike to harness their expertise to identify clinical deliverables to prevent, treat or cure this
compelling and complex disorder. The successful completion of the following aims of this planning grant will
hone our vision in tackling the TMD IMPACT challenge: (1) Organize, coordinate, and build an integrated multi-
disciplinary consortium to mechanistically understand TMJ health and disease, (2) Adapt existing scientific and
clinical centers and establish an administrative core which are integrated and focused on TMJ health and disease
research, (3) Develop clinical protocols, multi-site clinical research and trials network, and (4) Develop a research
training and education program that fosters interdisciplinary career development.
项目摘要
在美国大约有3500万人受到颞下颌关节紊乱病(TMD)的影响,
女性寻求治疗的可能性是男性的3-8倍,使其成为一种非常普遍和昂贵的疾病。
需要立即关注的医疗保健挑战。确定一个特定的和可治疗的原因,为TMD是
困难,因为它是由复杂的,多方面的相互作用引起的,涉及生物力学,生物学,
社会心理因素知之甚少。由于这些知识上的巨大差距和有限的
TMD的综合机制理解,成功的长期治疗方法和患者特异性
没有治疗指南。我们的建议,颞下颌关节交响乐:系统集成模型和
以患者为中心的整体结果和网络支持的培训和治疗机制,将在战略上
联合一个多学科、多规模的国家联盟,以破译之间的关系
颞下颌关节(TMJ)结构-功能-疼痛使用计算,细胞,动物和人类模型。
这群才华横溢的研究人员将建立在现有的MPI U 01基础上,专注于健康的TMJ结构-
内部NIDCR临床研究人员和外部基础科学家之间的功能。它将利用现有的
国家资源(例如RE-JOIN、OPPERA、DOCTRC),以加速发现的转化,
直接解决TMJ疾病诊断的技术(例如,多模态深度表型,生物标志物),
健康TMJ到临床前TMJ疾病到TMJ变性/疼痛的范围,治疗(例如,无创
整体/保守疗法、干细胞疗法、组织工程构建物),并改善结果
通过了解患者的适应能力、身心-颞下颌关节连接和环境
对不同患者行为和感知的影响以及TMJ健康/疾病的社会决定因素
人口在这一规划阶段,我们将制定战略,在机械知识方面取得巨大进展,
确定组合病因,同时扩大护理选择,提供循证治疗决策,
和针对患者的治疗模式。我们的乐观是有道理的,
已经在进行的方法和技术(例如,椅旁TMJ结构-功能-疼痛评估工具包
和深度临床表型、TMJ组学、多模态数据驱动模型)以及临床医生的积极性
和研究人员一样,利用他们的专业知识,以确定临床交付,以预防,治疗或治愈这一点
令人信服的和复杂的混乱。成功完成以下规划补助金目标将
在应对战区导弹防御系统影响的挑战中,我们要有这样的远见:(1)组织、协调和建立一个综合性的多层次、
学科联盟,机械地了解颞下颌关节的健康和疾病,(2)适应现有的科学和
临床中心,并建立一个行政核心,这是综合和重点颞下颌关节的健康和疾病
研究,(3)制定临床方案,多地点临床研究和试验网络,以及(4)制定研究
培训和教育计划,促进跨学科的职业发展。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
JANICE S LEE其他文献
JANICE S LEE的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('JANICE S LEE', 18)}}的其他基金
ATTRACT: Assessment of Temporomandibular JoinT MoRphology, Mechanics, And Mechanobiology in Class II and III Target and Surgical Phenotypes
ATTRACT:评估 II 类和 III 类目标和手术表型的颞下颌关节形态、力学和力学生物学
- 批准号:
10393966 - 财政年份:2022
- 资助金额:
$ 38.44万 - 项目类别:
ATTRACT: Assessment of Temporomandibular JoinT MoRphology, Mechanics, And Mechanobiology in Class II and III Target and Surgical Phenotypes
ATTRACT:评估 II 类和 III 类目标和手术表型的颞下颌关节形态、力学和力学生物学
- 批准号:
10551353 - 财政年份:2022
- 资助金额:
$ 38.44万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 38.44万 - 项目类别:
Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 38.44万 - 项目类别:
Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 38.44万 - 项目类别:
Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 38.44万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 38.44万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 38.44万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 38.44万 - 项目类别:
EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 38.44万 - 项目类别:
Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 38.44万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 38.44万 - 项目类别:
Research Grant