Collaborative for REsearch to Advance TMD Evidence (CREATE)
推进 TMD 证据的研究合作 (CREATE)
基本信息
- 批准号:10828983
- 负责人:
- 金额:$ 27.22万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-05 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:AcademyAdvocateBasic ScienceCaringCenter for Translational Science ActivitiesClinicalClinical ResearchCollectionConsensusDataDevelopmentDissemination and ImplementationEducationEducation and OutreachEnsureEvaluationEvidence based treatmentFAIR principlesFeedbackFocus GroupsFundingFutureGoalsHealth PersonnelHealthcareHumanHuman ResourcesIndividualIndustryInfrastructureInvestmentsKnowledgeLeadLeadershipLinkOrofacial PainPainPatient-Focused OutcomesPatientsPersonsPhasePhenotypePoliciesPre-Clinical ModelProceduresProcessProfessional OrganizationsProtocols documentationReportingResearchResearch InfrastructureResearch PersonnelResourcesRisk AssessmentScheduleSiteSpecificityTechnologyTemporomandibular Joint DisordersTemporomandibular joint disorder painTherapeutic InterventionTissue BanksTraining and InfrastructureTranslational ResearchTranslationsUnited StatesUnited States Food and Drug AdministrationValidationVisionWorkbench to bedsideclinical centerclinical phenotypeclinical translationdata exchangedata repositorydisorder preventiondisorder subtypeevidence baseimprovedinnovationknowledge integrationnovel diagnosticsnovel therapeuticspatient orientedpatient responsephenotypic datapre-clinicalpre-clinical assessmentpre-clinical researchpreclinical studypredictive markerpreventprogramsprospectiverecruitrepository infrastructureresearch data disseminationsafety testingshared repositorysuccesstranslational approachtranslational impacttranslational pipelineworking group
项目摘要
We propose to finally bridge the gap in our understanding of the relationship between
temporomandibular disorder (TMD) pain and underlying mechanisms, which will provide new
diagnostics and therapeutics for TMD patients. We envision that the TMD Collaborative for
Improving Patient-Centered Translational Research (TMD IMPACT) will address the need for:
TMD prevention, the development of effective and personalized TMD therapies, and expanding
the current work force of those researching and managing TMD pain by taking a bidirectional
translational approach. Our vision for TMD IMPACT involves five key components: 1) a Clinical
Phenotyping Core responsible for Clinical Centers across the US, to coordinate patient
assessment and analyses, ensure clinical studies include whole-person evaluations of
individuals with a TMD, the collection of phenotypic data that will be used to identify TMD
subtypes and biomarkers predictive of underlying mechanisms, and patient outcomes and
response to therapeutic interventions; 2) a Preclinical Core responsible for the validation of
preclinical models, establishing causal links between mechanisms and pain phenotypes, and for
the initial efficacy, specificity, and safety testing of therapeutic interventions; 3) a Data and
Biospecimen Management Core that will coordinate the integration of different data types and
storage of biospecimens, such that TMD IMPACT resources follow FAIR principles and provide
long-lasting impacts on TMD research into the future; 4) an Education and Outreach Core to
build scientific and clinical workforce capacity, thereby increasing the number of programs
pursuing preclinical and clinical TMD research, expanding the availability of evidence-based
care for people living with a TMD, and promoting dissemination and implementation of
advances made by the Collaborative; and 5) a Stakeholder Group consisting of patients/patient
advocates, payers, and industry representatives who will provide feedback on all Collaborative
efforts. During the proposed planning phase, our Collaborative for REsearch to Advance TMD
Evidence (CREATE) team will work with the other selected teams to lay the groundwork needed
to establish the TMD-Collaborative and achieve a shared vision for TMD-IMPACT. Our general
strategy will be to engage with funded sites and centers chosen for the TMD-IMPACT planning
phase, as they will have expertise and infrastructure relevant to the four core components of the
Collaborative.
我们建议最终弥合我们对两国关系的理解上的差距
颞下颌关节紊乱病(TMD)疼痛和潜在机制,这将提供新的
TMD患者的诊断和治疗。我们设想TMD协作组将
改进以患者为中心的翻译研究(TMD Impact)将满足以下需求:
TMD预防,开发有效和个性化的TMD疗法,并扩大
TMD疼痛双向研究和管理的现有工作力量
翻译方法。我们对TMD Impact的愿景包括五个关键组成部分:1)临床
负责美国各地临床中心的表型核心,以协调患者
评估和分析,确保临床研究包括对
患有TMD的个体,将用于识别TMD的表型数据的集合
预测潜在机制和患者预后的亚型和生物标记物
对治疗干预措施的反应;2)临床前核心负责验证
临床前模型,建立机制和疼痛表型之间的因果联系,并
治疗干预措施的初步有效性、特异性和安全性测试;3)数据和
Biosecimen管理核心,将协调不同数据类型和
储存生物武器,使战区导弹防御系统影响资源遵循公平原则并提供
对未来TMD研究的长期影响;4)教育和推广核心,以
建设科学和临床劳动力能力,从而增加项目数量
开展临床前和临床TMD研究,扩大循证医学的可获得性
关心患有TMD的人,并促进传播和实施
协作组取得的进展;以及5)由患者/患者组成的利益相关者小组
倡导者、付款人和行业代表将就所有协作项目提供反馈
努力。在建议的规划阶段,我们的合作研究以推进TMD
证据(创建)团队将与其他选定的团队合作,为所需的基础工作奠定基础
建立TMD-Collaborative,实现TMD-IMPACT的共同愿景。我们的将军
战略将是与为TMD-Impact规划选择的受资助地点和中心接触
阶段,因为他们将拥有与四个核心组成部分相关的专业知识和基础设施
协作性。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Alejandro Jose Almarza其他文献
Alejandro Jose Almarza的其他文献
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{{ truncateString('Alejandro Jose Almarza', 18)}}的其他基金
Polymer Scaffolds for Mandibular Condyle Cartilage Regeneration
用于下颌髁软骨再生的聚合物支架
- 批准号:
10469036 - 财政年份:2021
- 资助金额:
$ 27.22万 - 项目类别:
Polymer Scaffolds for Mandibular Condyle Cartilage Regeneration
用于下颌髁软骨再生的聚合物支架
- 批准号:
10523734 - 财政年份:2020
- 资助金额:
$ 27.22万 - 项目类别:
Polymer Scaffolds for Mandibular Condyle Cartilage Regeneration
用于下颌髁软骨再生的聚合物支架
- 批准号:
10308695 - 财政年份:2020
- 资助金额:
$ 27.22万 - 项目类别:
Polymer Scaffolds for Mandibular Condyle Cartilage Regeneration
用于下颌髁软骨再生的聚合物支架
- 批准号:
10524746 - 财政年份:2020
- 资助金额:
$ 27.22万 - 项目类别:
Polymer Scaffolds for Mandibular Condyle Cartilage Regeneration
用于下颌髁软骨再生的聚合物支架
- 批准号:
10746941 - 财政年份:2020
- 资助金额:
$ 27.22万 - 项目类别:
A Regenerative Medicine Approach for TMJ Meniscus Restoration
颞下颌关节半月板修复的再生医学方法
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8481533 - 财政年份:2012
- 资助金额:
$ 27.22万 - 项目类别:
A Regenerative Medicine Approach for TMJ Meniscus Restoration
颞下颌关节半月板修复的再生医学方法
- 批准号:
8365369 - 财政年份:2012
- 资助金额:
$ 27.22万 - 项目类别:
A Regenerative Medicine Approach for TMJ Meniscus Restoration
颞下颌关节半月板修复的再生医学方法
- 批准号:
8687974 - 财政年份:2012
- 资助金额:
$ 27.22万 - 项目类别:
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颞下颌关节半月板修复的再生医学方法
- 批准号:
8862181 - 财政年份:2012
- 资助金额:
$ 27.22万 - 项目类别:
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