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Polymer Scaffolds for Mandibular Condyle Cartilage Regeneration

用于下颌髁软骨再生的聚合物支架

基本信息

批准号：
10523734
负责人：
Alejandro Jose Almarza
金额：
$ 8.27万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-12-01 至 2024-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10523734
关键词：
4 year old Adult Architecture BMP2 gene Bilateral Binding Biochemical Biocompatible Materials Biological Assay Biological Availability Bone Regeneration Cartilage Cells Chondrocytes Chondrogenesis Data Defect Diffusion Family suidae Fibroblasts Fibrocartilages Functional Regeneration Gelatin Goat Growth Heparin Heparin Binding Hyaline Cartilage Hydrogels Implant In Vitro Infiltration Injury Kinetics Liquid substance Mandible Mandibular Condyle Mandibular Scaffold Miniature Swine Modeling Nanoporous Natural regeneration Operative Surgical Procedures Osteogenesis Pain Pathology Patients Perfusion Periodicity Permeability Phenotype Polymers Population Porifera Property Publishing Regenerative research Replacement Arthroplasty Site Technology Temporomandibular Joint Temporomandibular Joint Disorders Time Tissue Engineering Tissues Transforming Growth Factor beta articular cartilage base bioscaffold bone cartilage degradation cartilage regeneration cartilaginous clinically relevant condylar cartilage costal cartilage design ethylene glycol fibula healing implant design in vivo in vivo regeneration mechanical load mechanical properties migration novel osteochondral tissue osteoprogenitor cell prevent progenitor regeneration potential regenerative regenerative therapy regenerative treatment scaffold skeletal stem cells subchondral bone tissue regeneration treatment effect

项目摘要

The most severe cases of TMJ disorders consist of mandibular condyle degeneration. Unfortunately, no regenerative options exists and current treatments do not restore full function. The articulating tissue of the condyle is a fibrocartilage that consists of an intricate interface between fibrous, cartilaginous, and boney tissue that is essential for normal function and that is lost in severe TMJ disorders. The objective of this study is to regenerate fibrocartilage-bone interface of the mandibular condyle in skeletally mature goats using a comprehensive tissue engineering approach. A condylar defect will be treated with novel multilayer scaffold implant designed to promote site-specific tissue regeneration. We have strong pilot in-vivo data showing that our scaffolds components regenerate fibrous and cartilage tissue in our novel goat model, and bone in a segmental defect model. We will implant the scaffolds in a mediolateral grove-shaped condylar defect. We hypothesize that a multilayer scaffold will allow for site- specific fibrous-cartilage-bone regeneration of the mandibular condyle cartilage when compared to a homogenous sponge scaffold and untreated control defects. First, we will study the properties of a multilayer scaffold design in-vitro. We will characterize the permeability and release of TGFβs from the scaffold. Second, we will assess the functional healing of condylar defects treated with the multilayer scaffolds. We will assess mechanical properties, regenerate tissue composition, and condylar architecture formation using terminal assays at 1, 3 and 6 months post-surgery. Third, we will study the regeneration potential of three cell subpopulations found on the condyle. Successful completion of this proposal is the critical step to provide a regenerative therapy to treat TMJ mandibular cartilage degeneration, and a basis for successful osteochondral tissue regeneration in other sites.

最严重的TMJ疾病包括下颌髁突退变。