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Alliance for Regenerative Rehabilitation Research & Training 2.0 (AR3T)

再生康复研究联盟

基本信息

批准号：
10830114
负责人：
Fabrisia Ambrosio
金额：
$ 108.39万
依托单位：
SPAULDING REHABILITATION HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10830114
关键词：
Accountability Activities of Daily Living Age Attention Awareness Basic Science Biocompatible Materials Clinical Collaborations Communities Congenital Abnormality Country Data Analyses Development Disabled Persons Discipline Disease Documentation Education Effectiveness Eligibility Determination Ensure Evaluation Feedback Fostering Foundations Funding Future Goals In Vitro Incubators Individual Injury Institution Intervention Investigation Journals Knowledge Laboratories Learning Machine Learning Marketing Measurement Mentors Methodology Methods Mission Monitor Natural regeneration Organ Performance Physical Function Pre-Clinical Model Preparation Process Quality Control Reader Regenerative Medicine Rehabilitation therapy Research Research Design Research Personnel Resources Science Scientist Series Signal Transduction Specialist Stimulus Structure Systems Analysis Technology Text Time Tissues Training Trauma Treatment Efficacy Update career effectiveness evaluation falls functional restoration gait examination healing improved injured innovation interest mechanical stimulus multidisciplinary new technology novel novel strategies pre-clinical programs regeneration potential regenerative regenerative rehabilitation regenerative therapy rehabilitation research rehabilitation science repaired response sabbatical social media success symposium technological innovation technology validation therapy design tissue regeneration webinar

项目摘要

OVERALL: ABSTRACT The scope of regenerative medicine encompasses the repair, regeneration, and replacement of defective, injured, and diseased tissues and organs. The success of regenerative therapies is dependent, at least in part, on a favorable microenvironment in which the regenerative processes occur. Technological innovations and a deepened mechanistic understanding of how these microenvironmental signals influence tissue regeneration has drawn attention to the critical importance of the clinical field with foundations in the application of physical, thermal, and electrical stimuli to promote functional restoration—rehabilitation. We propose that the fields of regenerative medicine and rehabilitative science are inextricably intertwined, an intersection of disciplines that we and others have termed Regenerative Rehabilitation. To realize the full potential of Regenerative Rehabilitation, there is a need for formalized mechanisms that promote the interaction of basic scientists with rehabilitation specialists. During the initial funding cycle, the Alliance for Regenerative Rehabilitation Research & Training (AR3T) built a national network of investigators and programs that has helped to expand scientific knowledge, expertise and methodologies across the domains of regenerative medicine and rehabilitation. This proposal seeks funding for AR3T 2.0, in which we will build on successes achieved and lessons learned over the initial period of support with the goal of being even more responsive to the needs of the greater community. Six specific aims define a framework upon which we will achieve our goals. AR3T will provide education and drive the science underlying Regenerative Rehabilitation by: 1) Providing didactic programs that expose rehabilitation researchers to cutting-edge investigations and state-of-the-art technologies in the field of regenerative medicine (Didactic Aim); 2) Cultivating collaborative opportunities between renowned investigators in the fields of regenerative medicine and rehabilitation (Collaborations Aim); 3) Coordinating a pilot funding program to support novel lines of Regenerative Rehabilitation research (Pilot Funding Aim); 4) Developing and validating technologies to advance the measurement and use of the regenerative rehabilitation programs (Technology Aim); 5) Promoting our center’s expertise to a broad community of trainees, investigators, and clinicians (Promotion Aim); 6) Carefully monitoring and evaluating the effectiveness of our program will ensure that we are successful in achieving our goals (Quality Control Aim). Administrative note: In the preparation of this proposal, we made every effort to present a comprehensive and detailed plan for achieving our goals while minimizing redundancy. Therefore, in multiple places, we refer the reader to specific components of the application, rather than repeating text. We appreciate the time and effort the reviewers devote to the evaluation of the proposals. Sincerely, Fabrisia, Tom and Mike

总体：摘要再生医学的范围包括缺陷的修复、再生和更换，受伤，以及病变的组织和器官。再生疗法的成功至少在一定程度上取决于有利于再生过程发生的微环境。技术创新和加深了对这些微环境信号如何影响组织再生的机械理解提请注意有基础的临床领域在应用物理、热刺激和电刺激，以促进功能恢复-康复。我们建议将这些领域再生医学和康复科学密不可分，这是一门交叉学科，我们和其他人称之为再生康复。充分发挥再生的潜力在康复方面，有必要建立正式的机制，促进基础科学家与康复专家。在最初的筹资周期中，再生康复研究联盟与培训(AR3T)建立了一个由调查人员和项目组成的全国网络，帮助扩大了科学在再生医学和康复领域的知识、专门知识和方法。这提案寻求为AR3T 2.0提供资金，我们将在过去一年取得的成功和吸取的教训的基础上最初的支持期，目标是更好地响应广大社区的需求。六具体目标确定了我们将在其上实现我们的目标的框架。AR3T将提供教育和动力再生康复的科学基础是：1)提供教育项目，揭示康复研究人员致力于康复领域的前沿研究和最先进的技术再生医学(教学目标)；2)培养知名企业之间的合作机会再生医学和康复领域的研究人员(合作目标)；3)协调试点资助计划，支持再生康复研究的新路线(试点资助目标)；4) 开发和验证技术以促进再生性康复的测量和使用计划(技术目标)；5)向广泛的学员社区推广我们中心的专业知识，研究人员和临床医生(宣传目标)；6)认真监测和评估我们的计划将确保我们成功地实现我们的目标(质量控制目标)。行政说明：在准备这项提案时，我们尽一切努力提出了一份全面和在实现目标的同时将冗余降至最低的详细计划。因此，在多个地方，我们引用阅读应用程序的特定组件，而不是重复文本。我们感谢您所付出的时间和努力评审员们致力于对提案进行评估。诚挚的，法比西亚，汤姆和迈克