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Alliance for Regenerative Rehabilitation Research & Training 2.0 (AR3T)

再生康复研究联盟

基本信息

批准号：
10830114
负责人：
Fabrisia Ambrosio
金额：
$ 108.39万
依托单位：
SPAULDING REHABILITATION HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10830114
关键词：
Accountability Activities of Daily Living Age Attention Awareness Basic Science Biocompatible Materials Clinical Collaborations Communities Congenital Abnormality Country Data Analyses Development Disabled Persons Discipline Disease Documentation Education Effectiveness Eligibility Determination Ensure Evaluation Feedback Fostering Foundations Funding Future Goals In Vitro Incubators Individual Injury Institution Intervention Investigation Journals Knowledge Laboratories Learning Machine Learning Marketing Measurement Mentors Methodology Methods Mission Monitor Natural regeneration Organ Performance Physical Function Pre-Clinical Model Preparation Process Quality Control Reader Regenerative Medicine Rehabilitation therapy Research Research Design Research Personnel Resources Science Scientist Series Signal Transduction Specialist Stimulus Structure Systems Analysis Technology Text Time Tissues Training Trauma Treatment Efficacy Update career effectiveness evaluation falls functional restoration gait examination healing improved injured innovation interest mechanical stimulus multidisciplinary new technology novel novel strategies pre-clinical programs regeneration potential regenerative regenerative rehabilitation regenerative therapy rehabilitation research rehabilitation science repaired response sabbatical social media success symposium technological innovation technology validation therapy design tissue regeneration webinar

项目摘要

OVERALL: ABSTRACT The scope of regenerative medicine encompasses the repair, regeneration, and replacement of defective, injured, and diseased tissues and organs. The success of regenerative therapies is dependent, at least in part, on a favorable microenvironment in which the regenerative processes occur. Technological innovations and a deepened mechanistic understanding of how these microenvironmental signals influence tissue regeneration has drawn attention to the critical importance of the clinical field with foundations in the application of physical, thermal, and electrical stimuli to promote functional restoration—rehabilitation. We propose that the fields of regenerative medicine and rehabilitative science are inextricably intertwined, an intersection of disciplines that we and others have termed Regenerative Rehabilitation. To realize the full potential of Regenerative Rehabilitation, there is a need for formalized mechanisms that promote the interaction of basic scientists with rehabilitation specialists. During the initial funding cycle, the Alliance for Regenerative Rehabilitation Research & Training (AR3T) built a national network of investigators and programs that has helped to expand scientific knowledge, expertise and methodologies across the domains of regenerative medicine and rehabilitation. This proposal seeks funding for AR3T 2.0, in which we will build on successes achieved and lessons learned over the initial period of support with the goal of being even more responsive to the needs of the greater community. Six specific aims define a framework upon which we will achieve our goals. AR3T will provide education and drive the science underlying Regenerative Rehabilitation by: 1) Providing didactic programs that expose rehabilitation researchers to cutting-edge investigations and state-of-the-art technologies in the field of regenerative medicine (Didactic Aim); 2) Cultivating collaborative opportunities between renowned investigators in the fields of regenerative medicine and rehabilitation (Collaborations Aim); 3) Coordinating a pilot funding program to support novel lines of Regenerative Rehabilitation research (Pilot Funding Aim); 4) Developing and validating technologies to advance the measurement and use of the regenerative rehabilitation programs (Technology Aim); 5) Promoting our center’s expertise to a broad community of trainees, investigators, and clinicians (Promotion Aim); 6) Carefully monitoring and evaluating the effectiveness of our program will ensure that we are successful in achieving our goals (Quality Control Aim). Administrative note: In the preparation of this proposal, we made every effort to present a comprehensive and detailed plan for achieving our goals while minimizing redundancy. Therefore, in multiple places, we refer the reader to specific components of the application, rather than repeating text. We appreciate the time and effort the reviewers devote to the evaluation of the proposals. Sincerely, Fabrisia, Tom and Mike

总体：摘要再生医学的范围包括修复，再生和替换有缺陷的，受伤和患病的组织和器官。再生疗法的成功至少部分取决于有利于再生过程发生的微环境。技术创新和加深了对这些微环境信号如何影响组织再生的机制理解，提请注意临床领域的至关重要性，热刺激和电刺激，以促进功能性康复。我们建议，再生医学和康复科学是不可分割的交织在一起，学科的交叉，我们和其他人称之为再生康复。实现再生能源的全部潜力恢复，有必要建立正式的机制，促进基础科学家与康复专家。在最初的资助周期中，再生康复研究联盟和培训（AR 3 T）建立了一个全国性的调查人员和项目网络，有助于扩大科学研究，再生医学和康复领域的知识，专业知识和方法。这该提案旨在为AR 3 T 2.0提供资金，我们将在此过程中取得的成功和吸取的经验教训的基础上，支持的初始阶段，目标是更好地响应更大社区的需求。六具体目标确定了我们实现目标的框架。AR 3 T将提供教育和驱动再生康复的科学基础：1）提供教学计划，康复研究人员的尖端调查和国家的最先进的技术领域，再生医学（教学目标）; 2）培养知名人士之间的合作机会再生医学和康复领域的研究人员（合作目标）; 3）协调试点资助计划，以支持再生康复研究的新路线（试点资助目标）; 4）开发和验证技术，以促进再生康复的测量和使用 5）向广大的学员社区推广我们中心的专业知识，研究者和临床医生（推广目标）; 6）仔细监测和评估我们的有效性该计划将确保我们成功地实现我们的目标（质量控制目标）。行政说明：在编写本提案时，我们尽一切努力提出一个全面和详细的计划，以实现我们的目标，同时尽量减少冗余。因此，在多个地方，我们引用阅读器指向应用程序的特定组件，而不是重复文本。感谢你花时间和精力评审员致力于对提案进行评估。真诚的，Fabrisia，Tom和Mike