Connecting individual-level environmental exposures to cancer-related outcomes in a shorter-lived natural model system

在寿命较​​短的自然模型系统中将个体水平的环境暴露与癌症相关结果联系起来

• 批准号: 10831774
• 负责人: Elinor Karlsson
• 金额: $ 10万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-07 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10831774
• 关键词: Acceleration; Affect; Aging; Animals; Area; Biological Assay; Biological Models; Biopsy; Blood; Blood specimen; Canis familiaris; Carcinogens; Chemical Exposure; Chemicals; Chronic Disease; Collaborations; Collection; Communities; Companions; Data; Data Collection; Deposition; Dioxins; Disasters; Disease Progression; Enrollment; Environment; Environmental Exposure; Exposure to; Funding; Future; Goals; Grant; Hazardous Chemicals; Health; Hematopoiesis; Human; Incidence; Individual; Laboratories; Longevity; Longitudinal Studies; Malignant Neoplasms; Measurement; Modeling; Molecular Toxicology; Monitor; National Institute of Environmental Health Sciences; Ohio; Oregon; Outcome; Parents; Phase; Polycyclic Hydrocarbons; Positioning Attribute; Public Health; Reporting; Research; Risk; Role; Sampling; Secure; Sentinel; Site; Soil; Surveys; Technology; Testing; Time; Training; United States; Universities; Vinyl Chloride; Volatilization; Work; anticancer research; cancer care; cancer epidemiology; chemical spill; combustion product; community science; detection method; environmental toxicology; epidemiology study; improved; novel strategies; professor; recruit

Following a train derailment in East Palestine, Ohio on February 3, 2023, more than 100,000 gallons of hazardous chemicals consisting of vinyl chloride and other carcinogens were released into the environment directly and through controlled burn. This disaster offers an unfortunate opportunity to explore the role of external environmental exposure assessments in cancer epidemiology. We propose to use companion dogs as a model system to investigate chemical exposures near the disaster site and correlations with cancer incidence. Dogs share both indoor and outdoor environments with their human caretakers and spontaneously acquire many of the same chronic diseases that occur in humans, including cancer. With their shorter lifespans and accelerated onset and progression of disease, large numbers of dogs can be recruited in a shorter time span and provide faster outcomes for longitudinal studies informing human health. In our parent R01, we are using dogs as a model system for enhancing blood biopsy technology to improve its accuracy and utility for helping to guide cancer care. We have developed and validated methods for detecting clonal hematopoiesis (a possible precursor to cancer) and cancer in dogs through blood biopsies. We also developed a community science platform for dog cancer research that includes a study of environmental passive samplers in dogs. Here, we propose to pair blood biopsy technology with passive environmental samplers to investigate the feasibility and efficacy of using dogs as environmental sentinels to monitor for health consequences resulting from the train derailment and chemical spill. We will: Aim 1: Evaluate the relationship between proximity to the train derailment, increases in chemical exposures to combustion products and health outcomes. Aim 2: Evaluate the relationship between TD-CP exposures and the occurrence of clonal hematopoiesis and cancer using blood biopsies. This collaborative research effort will evaluate the utility of capturing individual-level environmental exposure information in cancer epidemiology.

在2023年2月3日在俄亥俄州东巴勒斯坦发生火车出轨之后，超过100,000 由乙烯基氯化物和其他致癌物组成的加仑危险化学物质是 直接释放到环境中，并通过受控烧伤。这场灾难提供了 不幸的机会探索外部环境暴露评估的作用 癌症流行病学。 我们建议将伴侣犬作为模型系统，以调查附近的化学暴露 灾难现场和与癌症发病率相关。狗共享室内和室外 环境与人类看护人，并自发地获得许多相同的慢性 包括癌症在内的人类发生的疾病。寿命较短，加速 疾病的发作和进展，可以在较短的时间内招募大量狗 跨越并为纵向研究提供更快的结果。 在我们的父r01中，我们将狗用作模型系统来增强血液活检技术 提高其准确性和实用性，以帮助指导癌症护理。我们已经开发了 经过验证的检测克隆造血的方法（癌症的可能前体）和 狗通过血液活检中的癌症。我们还为 狗癌研究包括对狗的环境被动采样器的研究。 在这里，我们建议将血液活检技术与被动环境采样器配对 调查使用狗作为环境前哨的可行性和功效以监测 火车出轨和化学溢出造成的健康后果。我们将： 目的1：评估距火车出轨的距离之间的关系，化学药品增加 暴露于燃烧产品和健康结果。 目标2：评估TD-CP暴露与克隆的发生之间的关系 使用血液活检的造血和癌症。 这项协作研究工作将评估捕获个人级别的实用性 癌症流行病学中的环境暴露信息。