Connecting individual-level environmental exposures to cancer-related outcomes in a shorter-lived natural model system

在寿命较​​短的自然模型系统中将个体水平的环境暴露与癌症相关结果联系起来

• 批准号: 10831774
• 负责人: Elinor Karlsson
• 金额: $ 10万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-07 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10831774
• 关键词: Acceleration; Affect; Aging; Animals; Area; Biological Assay; Biological Models; Biopsy; Blood; Blood specimen; Canis familiaris; Carcinogens; Chemical Exposure; Chemicals; Chronic Disease; Collaborations; Collection; Communities; Companions; Data; Data Collection; Deposition; Dioxins; Disasters; Disease Progression; Enrollment; Environment; Environmental Exposure; Exposure to; Funding; Future; Goals; Grant; Hazardous Chemicals; Health; Hematopoiesis; Human; Incidence; Individual; Laboratories; Longevity; Longitudinal Studies; Malignant Neoplasms; Measurement; Modeling; Molecular Toxicology; Monitor; National Institute of Environmental Health Sciences; Ohio; Oregon; Outcome; Parents; Phase; Polycyclic Hydrocarbons; Positioning Attribute; Public Health; Reporting; Research; Risk; Role; Sampling; Secure; Sentinel; Site; Soil; Surveys; Technology; Testing; Time; Training; United States; Universities; Vinyl Chloride; Volatilization; Work; anticancer research; cancer care; cancer epidemiology; chemical spill; combustion product; community science; detection method; environmental toxicology; epidemiology study; improved; novel strategies; professor; recruit

Following a train derailment in East Palestine, Ohio on February 3, 2023, more than 100,000 gallons of hazardous chemicals consisting of vinyl chloride and other carcinogens were released into the environment directly and through controlled burn. This disaster offers an unfortunate opportunity to explore the role of external environmental exposure assessments in cancer epidemiology. We propose to use companion dogs as a model system to investigate chemical exposures near the disaster site and correlations with cancer incidence. Dogs share both indoor and outdoor environments with their human caretakers and spontaneously acquire many of the same chronic diseases that occur in humans, including cancer. With their shorter lifespans and accelerated onset and progression of disease, large numbers of dogs can be recruited in a shorter time span and provide faster outcomes for longitudinal studies informing human health. In our parent R01, we are using dogs as a model system for enhancing blood biopsy technology to improve its accuracy and utility for helping to guide cancer care. We have developed and validated methods for detecting clonal hematopoiesis (a possible precursor to cancer) and cancer in dogs through blood biopsies. We also developed a community science platform for dog cancer research that includes a study of environmental passive samplers in dogs. Here, we propose to pair blood biopsy technology with passive environmental samplers to investigate the feasibility and efficacy of using dogs as environmental sentinels to monitor for health consequences resulting from the train derailment and chemical spill. We will: Aim 1: Evaluate the relationship between proximity to the train derailment, increases in chemical exposures to combustion products and health outcomes. Aim 2: Evaluate the relationship between TD-CP exposures and the occurrence of clonal hematopoiesis and cancer using blood biopsies. This collaborative research effort will evaluate the utility of capturing individual-level environmental exposure information in cancer epidemiology.

继2023年2月3日俄亥俄州东巴勒斯坦一列火车脱轨后，超过10万人 由氯乙烯和其他致癌物质组成的几加仑危险化学品 通过受控燃烧直接释放到环境中。这场灾难提供了一个 探索外部环境暴露评估在以下方面作用的不幸机会 癌症流行病学。 我们建议使用伴犬作为一个模型系统来调查附近的化学物质暴露 受灾地点及其与癌症发病率的相关性。狗可以在室内和室外共享 有人类照顾者的环境，并自发地获得许多相同的慢性 人类身上发生的疾病，包括癌症。它们的寿命更短，速度更快 疾病的发生和发展，可以在较短的时间内招募大量的狗 跨越并为告知人类健康的纵向研究提供更快的结果。 在我们的母公司R01中，我们使用狗作为增强血液活组织检查技术的模型系统 以提高其准确性和实用性，以帮助指导癌症护理。我们已经开发出了 经过验证的方法检测克隆性造血(可能是癌症的先兆)和 通过血液活组织检查患上狗的癌症。我们还开发了一个社区科学平台 狗癌研究，包括对狗的环境被动采样器的研究。 在这里，我们建议将血液活检技术与被动环境采样器配对，以 探讨用狗作为环境哨兵监测艾滋病的可行性和有效性。 火车脱轨和化学品泄漏造成的健康后果。我们会： 目的1：评估与火车脱轨、化学物质增加之间的关系 暴露于燃烧产物和健康后果。 目的2：评价TD-CP暴露与克隆发生的关系 使用血液活组织检查的造血和癌症。 这项合作研究工作将评估捕获个人级别的效用 癌症流行病学中的环境暴露信息。