Connecting individual-level environmental exposures to cancer-related outcomes in a shorter-lived natural model system

在寿命较​​短的自然模型系统中将个体水平的环境暴露与癌症相关结果联系起来

基本信息

项目摘要

Following a train derailment in East Palestine, Ohio on February 3, 2023, more than 100,000 gallons of hazardous chemicals consisting of vinyl chloride and other carcinogens were released into the environment directly and through controlled burn. This disaster offers an unfortunate opportunity to explore the role of external environmental exposure assessments in cancer epidemiology. We propose to use companion dogs as a model system to investigate chemical exposures near the disaster site and correlations with cancer incidence. Dogs share both indoor and outdoor environments with their human caretakers and spontaneously acquire many of the same chronic diseases that occur in humans, including cancer. With their shorter lifespans and accelerated onset and progression of disease, large numbers of dogs can be recruited in a shorter time span and provide faster outcomes for longitudinal studies informing human health. In our parent R01, we are using dogs as a model system for enhancing blood biopsy technology to improve its accuracy and utility for helping to guide cancer care. We have developed and validated methods for detecting clonal hematopoiesis (a possible precursor to cancer) and cancer in dogs through blood biopsies. We also developed a community science platform for dog cancer research that includes a study of environmental passive samplers in dogs. Here, we propose to pair blood biopsy technology with passive environmental samplers to investigate the feasibility and efficacy of using dogs as environmental sentinels to monitor for health consequences resulting from the train derailment and chemical spill. We will: Aim 1: Evaluate the relationship between proximity to the train derailment, increases in chemical exposures to combustion products and health outcomes. Aim 2: Evaluate the relationship between TD-CP exposures and the occurrence of clonal hematopoiesis and cancer using blood biopsies. This collaborative research effort will evaluate the utility of capturing individual-level environmental exposure information in cancer epidemiology.
2023年2月3日,俄亥俄州东巴勒斯坦发生火车脱轨事故,超过10万人死亡

项目成果

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Elinor Karlsson其他文献

Elinor Karlsson的其他文献

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{{ truncateString('Elinor Karlsson', 18)}}的其他基金

Leveraging canine spontaneous cancer to optimize the power of blood biopsy
利用犬自发癌优化血液活检的功效
  • 批准号:
    10634540
  • 财政年份:
    2021
  • 资助金额:
    $ 10万
  • 项目类别:
Leveraging canine spontaneous cancer to optimize the power of blood biopsy
利用犬自发癌优化血液活检的功效
  • 批准号:
    10421266
  • 财政年份:
    2021
  • 资助金额:
    $ 10万
  • 项目类别:
Leveraging canine spontaneous cancer to optimize the power of blood biopsy
利用犬自发癌优化血液活检的功效
  • 批准号:
    10844821
  • 财政年份:
    2021
  • 资助金额:
    $ 10万
  • 项目类别:
Transforming family dogs into a powerful and accessible model for human cancer
将家养狗转变为强大且易于使用的人类癌症模型
  • 批准号:
    10478250
  • 财政年份:
    2018
  • 资助金额:
    $ 10万
  • 项目类别:
Transforming family dogs into a powerful and accessible model for human cancer
将家养狗转变为强大且易于使用的人类癌症模型
  • 批准号:
    10462855
  • 财政年份:
    2018
  • 资助金额:
    $ 10万
  • 项目类别:
Transforming family dogs into a powerful and accessible model for human cancer
将家养狗转变为强大且易于使用的人类癌症模型
  • 批准号:
    9891974
  • 财政年份:
    2018
  • 资助金额:
    $ 10万
  • 项目类别:
A comprehensive canine genetics resource including gene and variation annotation
全面的犬类遗传资源,包括基因和变异注释
  • 批准号:
    9128056
  • 财政年份:
    2015
  • 资助金额:
    $ 10万
  • 项目类别:
A comprehensive canine genetics resource including gene and variation annotation
全面的犬类遗传学资源,包括基因和变异注释
  • 批准号:
    9238508
  • 财政年份:
    2015
  • 资助金额:
    $ 10万
  • 项目类别:

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Hormone therapy, age of menopause, previous parity, and APOE genotype affect cognition in aging humans.
激素治疗、绝经年龄、既往产次和 APOE 基因型会影响老年人的认知。
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The elucidation of the mechanism by which intestinal epithelial cells affect impaired glucose tolerance during aging
阐明衰老过程中肠上皮细胞影响糖耐量受损的机制
  • 批准号:
    19K09017
  • 财政年份:
    2019
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    $ 10万
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Does aging of osteocytes adversely affect bone metabolism?
骨细胞老化会对骨代谢产生不利影响吗?
  • 批准号:
    18K09531
  • 财政年份:
    2018
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    $ 10万
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Links between affect, executive function, and prefrontal structure in aging: A longitudinal analysis
衰老过程中情感、执行功能和前额叶结构之间的联系:纵向分析
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  • 财政年份:
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影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
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    9320090
  • 财政年份:
    2017
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    $ 10万
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Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
  • 批准号:
    10166936
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Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
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    9761593
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    2017
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    $ 10万
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衰老过程中抑郁症的实验模型:失眠、炎症和影响机制
  • 批准号:
    9925164
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Experimental Model of Depression in Aging: Insomnia, Inflammation, and Affect Mechanisms
衰老过程中抑郁症的实验模型:失眠、炎症和影响机制
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