Investigation of Anterior Cingulate Cortex Contributions to Hippocampal Cognitive Control
前扣带皮层对海马认知控制的贡献研究
基本信息
- 批准号:10827013
- 负责人:
- 金额:$ 6.91万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-11-01 至 2027-10-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAffectAnimal ExperimentationAnimalsAnteriorBehaviorBehavior ControlBehavioralBrainBrain regionCalciumCategoriesCognitiveComplexConflict (Psychology)Decision MakingDistalDistantElectrophysiology (science)Frontotemporal DementiaFunctional disorderFutureGeneticGoalsHippocampal FormationHippocampusHumanImageInheritedInvestigationLearningLesionLimbic SystemMapsMedialMediatingMemoryMental disordersMonitorMusNational Institute of Mental HealthNeuronsOutcomePerformancePhasePhotonsPopulationPopulation DynamicsPositioning AttributePrefrontal CortexProcessPyramidal CellsRattusResearchResourcesRetrievalRoleRotationSchizophreniaSensoryShockSignal TransductionSourceStimulusStrategic PlanningSynapsesTestingTimeTrainingWorkcingulate cortexcognitive controldesigner receptors exclusively activated by designer drugsentorhinal cortexexcitatory neuronexecutive functionexperienceexperimental studyflexibilityin vivoin vivo calcium imaginginsightmeetingsmemory retrievalneural
项目摘要
Project Abstract
Properly navigating our daily lives necessitates the judicious use of our limited cognitive resources to yield a
desired outcome. This ability, known as cognitive control, has been demonstrated in humans to depend heavily
on brain regions in the prefrontal cortex, including the anterior cingulate cortex, which is involved in effortful
decision making and performance monitoring. The hippocampus has also been implicated in cognitive control
function, particularly when the task depends on prior experience. Single-unit recordings of hippocampal neurons
have revealed a coordinated cognitive control signal that predicts cognitive control behavior. The mechanism of
cognitive control, and which brain regions contribute to it remains unclear, but the anterior cingulate is the most
likely candidate. Aim 1 will explore prefrontal cognitive control representations by using in-vivo single photon
calcium imaging to record populations of neurons within the anterior cingulate cortex (ACC) while rats perform
an active place avoidance task. This is a navigation based cognitive control task that will enable us to determine
if ACC also expresses a cognitive control signal, like in the signal in hippocampus. Whether or not a similar signal
exists does not preclude its involvement in cognitive control. Therefore Aim 2 will selectively inactivate ACC
using inhibitory chemogenetics (DREADDs) during the cognitive control task to test for necessity during various
behavioral phases. We will also record population neuronal activity from hippocampus CA1 during the
manipulations to evaluate the influence of cingulate inactivation on the hippocampal cognitive control signal.
Results from this research will reveal how cognitive control is represented in ACC and how this activity influences
hippocampal cognitive control, as well as provide a basis for interpreting how dysfunction that affects executive
function (such as schizophrenia and frontotemporal dementia) impact the brain. This work furthers Goal 1 of the
National Institute of Mental Health – defining the brain mechanisms underlying complex behaviors. Only by
addressing how cognitive control is represented and coordinated across multiple diverse brain regions can we
begin to construct a wholistic understanding of complex brain functions and mental illness.
项目摘要
正确地导航我们的日常生活需要明智地使用我们有限的认知资源,以产生一个
期望的结果。这种能力,被称为认知控制,已被证明在人类严重依赖
前额叶皮层的大脑区域,包括前扣带皮层,这与努力有关。
决策和业绩监测。海马体也与认知控制有关
特别是当任务依赖于先前的经验时。海马神经元的单单位记录
揭示了一个协调的认知控制信号,预测认知控制行为。的机理
认知控制,以及大脑区域对它的贡献仍然不清楚,但前扣带是最重要的
可能的候选人。目的1将探讨前额叶认知控制表征通过使用在体单光子
钙成像记录前扣带皮层(ACC)内的神经元群体,而大鼠执行
主动回避任务这是一个基于导航的认知控制任务,它将使我们能够确定
如果ACC也表达认知控制信号,就像海马体中的信号一样。是否有类似的信号
存在并不排除它参与认知控制。因此,目标2将选择性地抑制ACC
在认知控制任务中使用抑制性化学遗传学(DREADDs)来测试各种过程中的必要性。
行为阶段我们还将记录海马CA 1区的群体神经元活动,
操作,以评估扣带回失活对海马认知控制信号的影响。
这项研究的结果将揭示认知控制是如何在ACC中表现的,以及这种活动如何影响
海马认知控制,以及提供了一个解释如何影响执行功能障碍的基础,
功能障碍(如精神分裂症和额颞叶痴呆症)影响大脑。这项工作推动了《联合国千年宣言》的目标1。
国家心理健康研究所-定义复杂行为背后的大脑机制。只有
研究认知控制是如何在多个不同的大脑区域中表现和协调的,
开始构建对复杂大脑功能和精神疾病的整体理解。
项目成果
期刊论文数量(0)
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