BEATS: Binge drinking Ecological Antecedents with Transdermal alcohol monitoring Study.

BEATS：通过透皮酒精监测研究暴饮暴食的生态前因。

• 批准号: 10827305
• 负责人: Glenn-Milo Santos
• 金额: $ 18.88万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-20 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10827305
• 关键词: AIDS prevention; Acute; Address; Adult; Age; Alcohol consumption; Alcohols; American; Behavior; Behavior Therapy; Behavioral; Biosensor; Cellular Phone; Cessation of life; Data; Development; Ecological momentary assessment; Enrollment; Environment; Epidemic; Event; Future; HIV; HIV Infections; HIV risk; Heavy Drinking; Heterosexuals; Individual; Intervention; Laboratory Research; Link; Machine Learning; Measurement; Measures; Methods; Monitor; Multiple Partners; Outcome; Participant; Patient Self-Report; Pattern; Pharmacotherapy; Population; Prevalence; Prevention strategy; Procedures; Psychosocial Factor; Public Health; Reporting; Research Design; Risk Behaviors; San Francisco; Sex Behavior; Sexually Transmitted Diseases; Technology; Testing; Time; Unsafe Sex; Variant; Woman; Wrist; acceptability and feasibility; alcohol abuse therapy; alcohol intervention; alcohol monitoring; alcohol use disorder; behavior prediction; binge drinker; binge drinking; contextual factors; drinking; drinking behavior; economic cost; effective intervention; experience; follow-up; high risk; men; men who have sex with men; novel; personalized intervention; prediction algorithm; real time monitoring; recruit; risk prediction; risk prediction model; sexual HIV transmission; sexual risk behavior; sexually active; surveillance data; systematic review; therapy development; treatment program

PROJECT ABSTRACT Binge drinking (defined as drinking five or more drinks on one occasion for men, and four or more drinks for women), is highly prevalent in the US. Binge drinking accounts for more than half of the 80,000 annual deaths attributed to excessive alcohol consumption and its economic costs exceeds $191 billion in the US. National HIV Behavioral Surveillance data indicate that 48% of heterosexual men, 58% of men who have sex with men, and 40% of heterosexual women reported binge drinking (past 30 days). Binge drinking has been independently associated with condomless sex and HIV infection. Binge drinking is by far the most prevalent exposure linked to HIV infections. Current interventions for binge drinking and binge-drinking associated sexual behaviors remain limited. Most binge drinkers have never participated in alcohol or drug treatment programs and the vast majority of binge drinkers (90%) do not meet criteria for severe AUD. Real-time data on binge drinking and sexual episodes around binge drinking can inform interventions and there is a great need to examine the psychosocial factors that precede and predict these behaviors—i.e., the antecedents of binge alcohol and binge-drinking associated sexual risk behaviors. Ecological momentary assessments (EMA) is a method of collecting real-time data about an individual’s behaviors and experiences, often administered via cell phones. EMA can capture the contextual factors and circumstances preceding drinking behaviors, thereby providing a more nuanced understanding of the immediate antecedents of binge drinking. Recent advances in biosensor technology include the availability of wrist-worn monitors that can collect data on alcohol use, estimate number of drinks, and identify binge drinking episode using transdermal alcohol concentration (TAC). Hence, real-time data from EMA and biosensors for TAC can identifying high-risk situations and opportunities for personalized interventions. This study will develop risk prediction models for binge drinking and binge-drinking associated sexual behavior, which can ultimately help inform the development ecological momentary interventions (EMI) that will target high risk periods for binge drinking and binge-drinking associated sexual behaviors. Research Design Summary: This study, entitled “BEATS: Binge drinking Ecological Antecedents with Transdermal alcohol monitoring Study,” will enroll 100 sexually-active adults who binge drink alcohol and assess real-time antecedents for binge-drinking and binge-drinking associated sexual behaviors using EMA during a 30- day follow-up. Participants will also wear a small wrist biosensor that will track alcohol consumption and measure TAC continuously for 30 days. Data from the EMA and TAC will be analyzed using machine learning approaches to develop algorithms that predict risk for binge drinking (Aim 1) and binge-drinking associated sexual behaviors (Aim 2). We will also examine the feasibility and acceptability of EMA and biosensors in this population (Aim 3). Ultimately, findings will be used to inform future EMA-informed interventions.

项目摘要 酗酒（定义为男性一次喝五杯或更多，四杯或更多） 女性），在美国非常普遍。在每年8万例死亡中， 在美国，过度饮酒造成的经济损失超过1910亿美元。国家艾滋病毒 行为监测数据显示，48%的异性恋男性，58%的男男性行为者， 40%的异性恋女性报告酗酒（过去30天）。酗酒已经独立于 与无安全套性行为和艾滋病毒感染有关。酗酒是迄今为止最普遍的接触相关 艾滋病毒感染。目前对酗酒和酗酒相关性行为的干预仍然存在， 有限公司大多数酗酒者从未参加过酒精或药物治疗计划， 的酗酒者（90%）不符合严重AUD的标准。关于酗酒和性行为的实时数据 酗酒周围的事件可以为干预提供信息，非常需要检查心理社会因素， 在这些行为之前和预测这些行为的因素-即，酗酒的前因 相关的性风险行为。生态瞬时评估（EMA）是一种收集实时数据的方法， 关于个人行为和经历的数据，通常通过手机管理。EMA可以捕获 饮酒行为之前的背景因素和环境，从而提供了一个更细致入微的 了解酗酒的直接原因。生物传感器技术的最新进展包括 腕戴式监控器的可用性，可以收集酒精使用数据，估计饮酒数量，并识别 使用透皮酒精浓度（TAC）的酗酒发作。因此，EMA的实时数据和 TAC的生物传感器可以识别高风险情况和个性化干预的机会。这 这项研究将建立酗酒和酗酒相关性行为的风险预测模型， 最终有助于为针对高风险的开发生态瞬时干预（EMI）提供信息 酗酒和酗酒相关性行为的时期。 研究设计摘要：这项研究，题为“BEATS：酗酒的生态前因， 经皮酒精监测研究”将招募100名性活跃的成年人，他们酗酒，并评估 使用EMA在30年内对暴饮暴食和暴饮暴食相关性行为进行实时前因分析 日随访。参与者还将佩戴一个小型手腕生物传感器，该传感器将跟踪酒精消耗并测量 TAC连续30天。来自EMA和TAC的数据将使用机器学习方法进行分析 开发预测酗酒（目标1）和酗酒相关性行为风险的算法 (Aim 2）。我们还将检查EMA和生物传感器在该人群中的可行性和可接受性（目标3）。 最终，调查结果将用于为未来的环境管理评估知情干预提供信息。