Frailty and Monitored Anesthesia Care for Cataract Surgery in Older Adults - Administrative Supplement

老年人白内障手术的虚弱和监测麻醉护理 - 行政补充

• 批准号: 10825387
• 负责人: Catherine Lee Chen
• 金额: $ 7.56万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10825387
• 关键词: Administrative Supplement; Adverse event; Age; Anesthesia procedures; Anesthesiology; Anesthetics; Anxiety; Area; Associate Degree; Biometry; Biostatistical Methods; Caring; Case Series; Cataract; Cataract Extraction; Certified registered nurse anesthetist; Characteristics; Complication; Country; Deimplementation; Dementia; Development Plans; Elderly; Elements; Evaluation; Event; Exposure to; Eye; Foundations; Frequencies; Funding; Future; Geriatrics; Gerontology; Goals; Health Services; Health Services Research; Healthcare Systems; Incidence; Institution; Intervention; Interview; Intraoperative Monitoring; Intravenous; Intravenous Anesthetics; K-Series Research Career Programs; Knowledge; Measures; Medicare claim; Mentors; Mentorship; Modernization; Monitor; Morbidity - disease rate; Operating Rooms; Operative Surgical Procedures; Ophthalmologist; Ophthalmology; Oral; Outcome; Outcome Study; Patients; Perioperative; Perioperative Care; Pilot Projects; Policy Maker; Population; Positioning Attribute; Postoperative Period; Procedures; Process; Provider; Publishing; Qualitative Research; Quality of life; Research; Research Methodology; Research Personnel; Resources; Risk; Safety; Sedation procedure; Structure; Techniques; Testing; Training; Visual impairment; Weight; acceptability and feasibility; adverse outcome; career; career development; cost; design; effectiveness/implementation trial; evidence base; frailty; functional outcomes; high risk; implementation framework; implementation intervention; implementation science; improved; interest; intravenous administration; medical specialties; mortality; multiple chronic conditions; patient safety; preference; preservation; recruit; satisfaction; standard of care; success; surgery outcome; treatment as usual; uptake

Project Summary The vast majority of older adults undergo cataract surgery with 1-to-1 intraoperative monitoring and sedation administered by an anesthesiologist or nurse anesthetist (a.k.a., “monitored anesthesia care” or “MAC”). Proponents of MAC believe that cataract patients—many of whom are frail due to a combination of advanced age, multimorbidity and underlying visual impairment—generally benefit from close intraoperative monitoring by an anesthesia professional. However, given the procedure’s overall safety profile and the projected increase in cataract surgery demand as the US population ages, policymakers, clinicians, and payers have questioned whether the routine use of MAC for cataract surgery should continue in the US. Currently, there is inadequate evidence to predict which patients would be at highest risk for harm if MAC were to be removed as a component of routine cataract surgery. The rationale underlying the proposed research is that identifying the characteristics of patients at highest risk of harm could help facilitate a careful transition to non-MAC cataract surgery for the majority of patients who would be safe to proceed (and would not be harmed) without MAC. The central hypothesis is that the provision of MAC is only necessary for a relatively small subset of high-risk older adults undergoing cataract surgery. To test this hypothesis, the proposed research plan will investigate three aims. Aim 1 will examine the relationship between frailty, MAC, and the incidence of adverse events after cataract surgery through retrospective analysis of Medicare claims. Aim 2 will shed light on the facilitators and barriers for performing cataract surgery without MAC using semi-structured interviews of ophthalmologists whose practices represent a range of MAC utilization. Aim 3 will carry out a pilot study of low-risk older adults undergoing cataract surgery to determine feasibility and acceptability of non-MAC sedation for cataract surgery. These aims will create foundational knowledge to support future studies that can determine whether MAC can safely be removed as a component of routine cataract surgery in low-risk older adults. The Candidate is an anesthesiologist and health services researcher at UCSF. The Candidate, her mentors and her scientific advisors have developed a comprehensive career development plan that aligns well with the Aims of the proposed research. The key elements of this plan include training and didactics to obtain specialty knowledge in the following areas: 1) Principles of geriatrics and gerontology, 2) Biostatistical methods for advanced causal inference; 3) Introduction to qualitative research methodologies; 4) Implementation science and feasibility pilot studies, and 5) Structured career development with exposure to thought leaders in geriatrics, health services research, ophthalmology, and anesthesiology. This career development award will help the Candidate achieve her goal of becoming a national leader in geriatric perioperative health services research at the forefront of promoting evidence-based, high-value surgical and anesthetic care in older adults. With strong institutional commitment, the Candidate is well-positioned to attain research independence.

项目摘要 绝大多数老年人接受白内障手术，术中1对1监测和镇静 由麻醉师或护士麻醉师（a.k.a.，“监测麻醉护理”或“MAC”）。 MAC的支持者认为，白内障患者-其中许多人是脆弱的，由于先进的组合 年龄、多发病和潜在的视力损害-通常受益于术中密切监测 麻醉专家的帮助然而，考虑到手术的整体安全性和预期的增加， 随着美国人口老龄化，白内障手术需求，政策制定者，临床医生和支付者质疑 在美国是否应继续常规使用MAC进行白内障手术。目前， 如果MAC被移除，预测哪些患者将面临最高伤害风险的证据 常规白内障手术的组成部分。拟议研究的基本原理是， 伤害风险最高的患者的特征可能有助于谨慎过渡到非MAC白内障 手术对于大多数患者来说是安全的（并且不会受到伤害），没有MAC。 中心假设是，MAC的规定只需要一个相对较小的子集的高风险 接受白内障手术的老年人。为了验证这一假设，拟议的研究计划将调查 三个目标。目的1将检查虚弱，MAC和不良事件发生率之间的关系， 白内障手术通过回顾性分析医疗保险索赔。目标2将阐明促进者和 通过半结构化眼科医生访谈探讨无MAC白内障手术的障碍 其实践代表了MAC利用率的范围。目标3将对低风险老年人进行试点研究 接受白内障手术，以确定非MAC镇静治疗白内障的可行性和可接受性 手术这些目标将创造基础知识，以支持未来的研究，可以确定是否 MAC可以安全地作为低风险老年人常规白内障手术的一部分。的 候选人是加州大学旧金山分校的麻醉师和健康服务研究员。候选人，她的导师和 她的科学顾问已经制定了一个全面的职业发展计划， 拟议研究的目的。该计划的关键要素包括培训和教学法，以获得专业 在以下领域的知识：1）老年医学和老年学的原则，2）生物统计方法， 高级因果推理; 3）介绍定性研究方法; 4）实施科学 和可行性试点研究，以及5）结构化的职业发展，接触思想领袖， 老年医学、卫生服务研究、眼科学和麻醉学。该职业发展奖将 帮助候选人实现成为全国老年围手术期卫生服务领导者的目标 研究处于促进老年人循证、高价值手术和麻醉护理的前沿。 凭借强大的机构承诺，候选人处于有利地位，以实现研究的独立性。

项目成果

Does Propofol Improve Polyp Detection during Colonoscopy? The Promise and Peril of Clinical Registry Data.

异丙酚能否改善结肠镜检查期间息肉的检测？

• DOI: 10.1097/aln.0000000000004987
• 发表时间: 2024
• 期刊: Anesthesiology
• 影响因子: 8.8
• 作者: Colquhoun,DouglasA;Somsouk,Ma;Chen,CatherineL
• 通讯作者: Chen,CatherineL

The Triple Bottom Line and Stabilization Wedges: A Framework for Perioperative Sustainability.

• DOI: 10.1213/ane.0000000000005890
• 发表时间: 2022-03-01
• 期刊: ANESTHESIA AND ANALGESIA
• 影响因子: 5.7
• 作者: Choi, Bong Joon James;Chen, Catherine L.
• 通讯作者: Chen, Catherine L.

The association of multimodal analgesia and high-risk opioid discharge prescriptions in opioid-naive surgical patients.

• DOI: 10.1186/s13741-021-00230-3
• 发表时间: 2021-12-15
• 期刊: Perioperative medicine (London, England)
• 作者: Langnas E;Rodriguez-Monguio R;Luo Y;Croci R;Dudley RA;Chen CL
• 通讯作者: Chen CL

Enhanced recovery after surgery protocol and postoperative opioid prescribing for cesarean delivery: an interrupted time series analysis.

• DOI: 10.1186/s13741-021-00209-0
• 发表时间: 2021-11-15
• 期刊: Perioperative medicine (London, England)
• 作者: Langnas EM;Matthay ZA;Lin A;Harbell MW;Croci R;Rodriguez-Monguio R;Chen CL
• 通讯作者: Chen CL

Opioid prescribing practices at hospital discharge for surgical patients before and after the Centers for Disease Control and Prevention's 2016 opioid prescribing guideline.

• DOI: 10.1186/s12871-022-01678-6
• 发表时间: 2022-05-11
• 期刊: BMC ANESTHESIOLOGY
• 影响因子: 2.2
• 作者: Langnas, Erica;Bishara, Andrew;Croci, Rhiannon;Rodriguez-Monguio, Rosa;Wick, Elizabeth C.;Chen, Catherine L.;Guan, Zhonghui
• 通讯作者: Guan, Zhonghui