FFRDC MOONSHOT PORTFOLIO TASK ORDER - COPTR (DCP)

FFRDC 登月组合任务订单 - COPTR (DCP)

基本信息

  • 批准号:
    10823197
  • 负责人:
  • 金额:
    $ 22.35万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-08-31 至 2024-09-30
  • 项目状态:
    已结题

项目摘要

The Cancer MoonshotSM was designed to accelerate efforts to prevent, diagnose, and treat cancer and achieve 10 years of progress in 5 years. The associated Symptom Management Research Blue Ribbon Panel (BRP) identified the need for strategic investment in the collection of patient-reported symptom data and the use of that data to inform decision-making and improve clinical management. Specifically, the BRP noted that validated patient-reported measures (PROs) have led to advances in the systematic collection of patient-reported symptoms and functional status. However, these advances have not occurred uniformly across all populations, particularly among minority and underserved populations. Furthermore, these populations often have significant delays in treatment, experience worse side effects, are more likely to be nonadherent to treatment, and have less access to remedies to control their side effects. Consequently, they are at high risk for impaired quality of life, functionality, working, and family relationships. Within this population of minority and underserved can be found a growing number of non-English or low-English proficient speaking individuals. While the Panel noted that systematically gathered PRO data from underserved populations are needed, without adequate and appropriate translations of PRO questionnaires, non-English and low-English proficient patients will remain marginalized, undertreated, and underrepresented in clinical trials. While most of general quality of life questionnaires and the Patient Reported Outcome-Common Terminology Criteria for Adverse Events (PRO-CTCAE) are translated in multiple languages, some gaps remain. In addition, protocols often include ancillary non-validated materials (e.g., patient diaries,instructions) that are typically only available in English. Finally, neurocognitive tests are frequently used in both adult and pediatric trials and the lack of translations limits participation of non-English speakers. Thus, this Moonshot effort is intended to improve accrual of Spanish and French speakers to the NCORP clinical trial portfolio by ensuring the availability of the necessary translated materials. The NCI Community Oncology Research Program (NCORP) is a national NCI-supported network that designs and conducts cancer prevention, supportive care and symptom management, screening, and surveillance clinical trials. The NCORP is housed in the NCI Division of Cancer Prevention and collaborates with numerous other NCI Divisions and Offices. NCORP is comprised of 7 Research Bases and 46 Community Sites, 14 of which are designated as Minority/Underserved Community Sites. The NCORP Research Bases are hubs for the network that design and spearhead the conduct of multi-center clinical trials and provide overall administration, data management, scientific and statistical leadership, operational processes and personnel, and regulatory compliance. The NCORP Community Sites accrue participants to NCI-approved cancer clinical trials and research studies. The Sites are consortia of researchers, public hospitals, physician practices, academic medical centers, health systems and other groups that provide healthcare services in communities across the U.S.
Cancer MoonshotSM旨在加速预防、诊断和治疗癌症的努力,并在5年内取得10年的进展。相关的症状管理研究蓝带小组(BRP)确定了在收集患者报告的症状数据方面进行战略投资的必要性,并利用这些数据为决策提供信息并改善临床管理。具体而言,BRP指出,经验证的患者报告措施(PRO)已导致系统收集患者报告症状和功能状态的进展。然而,这些进展并没有在所有人口中均匀地发生,特别是在少数民族和服务不足的人口中。此外,这些人群往往有显着的治疗延误,经验更糟糕的副作用,更有可能是不遵守治疗,并有较少的补救措施,以控制其副作用。因此,他们的生活质量、功能、工作和家庭关系受损的风险很高。在这些少数民族和服务不足的人口中,可以发现越来越多的非英语或英语水平较低的人。虽然专家小组指出,需要从服务不足的人群中系统收集PRO数据,但如果没有PRO问卷的充分和适当翻译,非英语和英语水平低的患者将在临床试验中继续被边缘化,治疗不足和代表性不足。 虽然大多数一般生活质量问卷和患者报告的结局-不良事件通用术语标准(PRO-CTCAE)都被翻译成多种语言,但仍存在一些差距。此外,协议通常包括辅助的未经验证的材料(例如,患者日记、说明书),通常只有英文版。最后,神经认知测试经常用于成人和儿科试验,缺乏翻译限制了非英语母语者的参与。因此,这项Moonshot工作旨在通过确保必要的翻译材料的可用性,提高NCORP临床试验组合中西班牙语和法语使用者的增加。 NCI社区肿瘤学研究计划(NCORP)是一个由NCI支持的国家网络,设计和进行癌症预防,支持性护理和症状管理,筛查和监测临床试验。NCORP设在NCI癌症预防部门,并与许多其他NCI部门和办公室合作。NCORP由7个研究基地和46个社区网站组成,其中14个被指定为少数民族/服务不足的社区网站。NCORP研究基地是网络的枢纽,设计和带头进行多中心临床试验,并提供整体管理,数据管理,科学和统计领导,运营流程和人员以及法规遵从性。NCORP社区网站招募参与者参加NCI批准的癌症临床试验和研究。这些网站是由研究人员、公立医院、医生诊所、学术医疗中心、卫生系统和其他团体组成的联盟,在美国各地的社区提供医疗服务。

项目成果

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{{ truncateString('CHRISTINE SIEMON', 18)}}的其他基金

FFRDC MOONSHOT PORTFOLIO TASK ORDER - CRISPR gRNA Reagents for NGCMs
FFRDC MOONSHOT 组合任务订单 - 用于 NGCM 的 CRISPR gRNA 试剂
  • 批准号:
    10716701
  • 财政年份:
    2019
  • 资助金额:
    $ 22.35万
  • 项目类别:
FFRDC MOONSHOT PORTFOLIO TASK ORDER - COPTR (DCP)
FFRDC 登月组合任务订单 - COPTR (DCP)
  • 批准号:
    10716703
  • 财政年份:
    2019
  • 资助金额:
    $ 22.35万
  • 项目类别:

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