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UTMB-Novartis Alliance for Pandemic Preparedness

UTMB-诺华流行病防范联盟

基本信息

批准号：
10845855
负责人：
Thierry Diagana
金额：
$ 1884.9万
依托单位：
UNIVERSITY OF TEXAS MED BR GALVESTON
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-05-16 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10845855
关键词：
2019-nCoV Academia Air Antiviral Agents Biology COVID-19 COVID-19 assay COVID-19 pandemic Cells Cessation of life Clinical Collaborations Communicable Diseases Communication Complex Coronavirus Data Decision Making Dengue Development Diagnostic Drug Targeting Education Emerging Technologies Ensure Faculty Family Flavivirus Foundations Future Generations Goals Hendra Virus Henipavirus Home Human Humanities Industry Infection Institution Intellectual Property Investments Laboratories Learning Libraries Life Machine Learning Marketing Medical Medicine Membrane Proteins Mentors Middle East Respiratory Syndrome Coronavirus Nipah Virus Nongovernmental Organizations Nucleosides Nucleotides Oral Peptide Hydrolases Pharmaceutical Preparations Pharmacologic Substance Phase I Clinical Trials Phenotype Polymerase Population Density Postdoctoral Fellow Predisposition Private Sector Privatization Probability Process Productivity Protease Inhibitor Quantitative Structure-Activity Relationship RNA-Directed RNA Polymerase Rationalization Research Research Activity Research Project Grants Resistance SARS-CoV-2 inhibitor Seasons Serotyping Spanish flu Technology Texas Training Translational Research Travel United States National Institutes of Health Universities Vaccines Viral Virus biosafety level 4 facility clinical candidate clinical investigation combat drug candidate drug discovery economic cost inhibitor innovation mortality multidisciplinary new technology next generation novel pandemic disease pandemic potential pandemic preparedness prevent pandemics programs public health relevance public-private partnership recruit response role model screening student training success synergism translational impact viral pandemic virology

项目摘要

OVERALL – ABSTRACT Pandemic prevention and preparedness is a major scientific and societal priority that requires sustained and forward looking investments across governmental, non-governmental, academic and private sectors to develop an arsenal of countermeasures against the existential threat of viral pandemics. Combining world-leading BSL3/4 capabilities at University of Texas of Medical Branch (UTMB) and state-of-the art drug discovery technologies at Novartis, the UTMB Novartis Alliance for Pandemic Preparedness (UNAPP), is a unique and innovative partnership that brings together the multi-disciplinary expertise required to deliver high quality antiviral drug candidates. Enabled by world-leading virologists and seasoned drug hunters, UNAPP will aggressively prosecute a portfolio of 5 projects aiming to discover orally available, safe, and effective drugs against coronaviruses, flavivirus and henipavirus, three major classes of viruses with pandemic potential. The projects portfolio combines approaches targeting well validated drug targets, such as the RNA- dependent RNA polymerases and viral proteases, as well as phenotypic screening, which will allow for the discovery of clinical drug candidates and novel targets that will advance our fundamental understanding of the biology of those viruses. Four scientific Cores—Virology, High-Throughput Biology, Drug Discovery and Translational Research Cores—will provide technological and scientific expertise to support Project Teams and implement the scientific strategy toward novel antiviral drugs. The UNAPP will be governed by an Administrative Core which will be co-led by the PIs, Dr. Pei-Yong Shi and Dr. Thierry Diagana, who have a long track-record of successfully working together. Both PIs have led multiple productive collaborations focused on translational impact and combining public, private and non-governmental organizations. The Administrative Core will provide integrated decision making in scientific, operational, financial, intellectual property protection, and communication. In collaboration with all project and Core leaders, as well as with external input from a Scientific Advisory Board and NIH program officers, they will ensure that the projects portfolio leverages the full spectrum of technologies and capabilities residing in all four scientific Cores, capturing synergies across projects through cross-learning and efficient deployment of platforms relevant to multiple viruses. Because of the unique complementarity of the scientific Cores and the remarkable synergies of the project portfolio, we fully expect that the UNAPP will yield exceptional productivity and deliver all the proposed objectives: (1) Deliver 3 IND-ready candidates and 3 Development Candidates, (2) advance antiviral research, and (3) train next-generation drug hunters.

总体-摘要大流行病预防和防备是一项重大的科学和社会优先事项，需要持续和政府、非政府、学术和私营部门的前瞻性投资，对付病毒大流行的生存威胁的一整套对策。结合世界领先的德克萨斯大学医学分支（UTMB）的BSL 3/4能力和最先进的药物发现 UTMB诺华大流行病防范联盟（UNAPP）是诺华公司的一项独特技术，和创新的合作伙伴关系，汇集了提供高质量所需的多学科专业知识抗病毒候选药物。在世界领先的病毒学家和经验丰富的药物猎人的帮助下，UNAPP将积极开展5个项目，旨在发现口服、安全和有效的药物针对冠状病毒、黄病毒和亨尼帕病毒，这三种大流行性病毒潜力该项目组合结合了针对经过充分验证的药物靶点的方法，如RNA- 依赖的RNA聚合酶和病毒蛋白酶，以及表型筛选，这将允许发现临床候选药物和新靶点，这将促进我们对药物的基本理解。这些病毒的生物学。四大科学核心--病毒学、高通量生物学、药物发现和转化研究核心-将提供技术和科学专业知识，以支持项目团队，实施新型抗病毒药物的科学战略。联合国预防犯罪和刑事司法方案将由一个核心将由PI，Pei-Yong Shi博士和Thierry Diagana博士共同领导，他们有着长期的成功地一起工作。两位PI都领导了多项富有成效的合作，影响和结合公共、私人和非政府组织。行政核心将提供在科学、业务、财务、知识产权保护和通信与所有项目和核心领导人合作，并与科学家的外部投入合作，顾问委员会和NIH项目官员，他们将确保项目组合利用全方位所有四个科学核心中的技术和能力，通过以下方式实现项目之间的协同增效：交叉学习和有效部署与多种病毒相关的平台。因为独特的科学核心的互补性和项目组合的显著协同作用，我们完全期望，联合国非洲开发新伙伴关系项目将产生卓越的生产力，并实现所有拟议目标：（1）交付3个国家研究开发就绪项目候选人和3个发展候选人，（2）推进抗病毒研究，（3）培养下一代毒品猎人