High Throughput Biology Core
高通量生物学核心
基本信息
- 批准号:10845858
- 负责人:
- 金额:$ 59.98万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-05-16 至 2025-04-30
- 项目状态:未结题
- 来源:
- 关键词:Antiviral AgentsArchivesAreaAutomationBiochemicalBiologicalBiological AssayBiologyCell Culture SystemCellsChemicalsCollaborationsCoronavirusDataData Management ResourcesDedicationsDevelopmentDiseaseDoseEnabling FactorsFlavivirusFundingGenerationsGoalsGuidelinesHenipavirusIn VitroInfrastructureKnowledgeLeadLibrariesLiquid substanceMachine LearningMassachusettsMedicalMiniaturizationModelingMolecular TargetPathway interactionsPharmaceutical ChemistryPhenotypePropertyProteinsRecombinant ProteinsRecombinantsRepliconReporterResearchResourcesRoboticsScienceSiteSpecificityStructure-Activity RelationshipSwitzerlandSystemTestingTexasUniversitiesValidationViralViral ProteinsVirusWorkassay developmentclinical candidatecytotoxicitydata integritydesigndrug discoveryhigh throughput screeningimprovedinstrumentationinterestlead candidatelead optimizationminiaturizenovelpandemic preparednessprotein expressionresponsescreeningsmall molecule librariestoolvectorvirology
项目摘要
HIGH-THROUGHPUT BIOLOGY CORE – ABSTRACT
The High-Throughput Biology Core will support Project Teams with target-based and phenotypic high-throughput
screening (HTS) campaigns to identify diverse tractable chemical matter and SAR (structure-activity
relationship)-enabling primary dose-response assays for lead identification and optimization efforts. This will be
achieved in close collaboration with the Virology Core (providing molecular target hypothesis and develop BSL2
suitable vectors for translatable in vitro phenotypic assay systems) and the Drug Discovery Core (helping to
design tailored screening sets for iterative HTS and providing medicinal chemistry support to enable lead
identification and optimization). The High-Throughput Biology Core, with established in-house expertise in
assay development and miniaturization, proficiency in diverse recombinant protein expression systems,
compound and data management systems, and state-of-the-art screening and automation infrastructure
including BSL2 HTS capability, will enable HTS to identify new chemical starting points for drug discovery and
also validate new targets. Further, the High-Throughput Biology Core will also enable medicinal chemistry
efforts to improve on-target potency and enhance selectivity with robust SAR-enabling primary dose-response
assays. This will facilitate the optimization of lead candidates with improved physiochemical properties having
desirable potency, selectivity and ADME properties to ultimately deliver safe and efficacious promising clinical
candidates. In summary, the High-Throughput Biology Core will enable UNAPP’s drug discovery efforts
by helping Project Teams to identify tractable diverse chemical matter necessary to validate new targets
and support antiviral drug discovery to ultimately select the best candidate for development.
高通量生物学核心-摘要
项目成果
期刊论文数量(0)
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会议论文数量(0)
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