Mechanisms of action of neurochemicals and modulators in human intestine: changes in disease

神经化学物质和调节剂在人肠道中的作用机制：疾病的变化

• 批准号: nhmrc : 222739
• 负责人: A/Pr Lu Liu
• 金额: $ 29.51万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-action-neurochemicals-changes-disease/100253
• 关键词: Mechanisms; action; neurochemicals; modulators; human

Inflammatory bowel disease (IBD) and idiopathic chronic constipation (ICC) are two serious gastrointestinal disorders, for which no effective medical treatment is known. We will investigate the hypothesis that abnormalities in the nerve chemicals found in the gut contribute to the aetiology of these diseases. Our studies will examine the sites of action (receptors) for these chemicals (neurotensin and acetylcholine) in the small and large intestine. The mechanisms governing motility changes in response to these chemicals have been well studied in animal intestine, but there is little detailed information from the human intestine. This study will provide insight into the mechanisms operating in the normal bowel, providing a base for comparing bowel obtained from patients with IBD or ICC. We will also study bowel removed at surgery for acute diverticular disease (DD), representing another type of inflammation. Studies on isolated segments of colon from ICC patients will determine whether the contractility of the muscle is abnormal in general or only with respect to the chemicals under investigation. Other studies will investigate the inflammatory processes occurring in the bowel and whether this differs in IBD. Our work will facilitate understanding of the function of the bowel in health and in gastrointestinal disorders and may lead to new medical treatments for IBD and ICC.

炎症性肠病（IBD）和特发性慢性便秘（ICC）是两种严重的胃肠道疾病，目前尚无有效的治疗方法。我们将研究这样的假设：肠道中发现的神经化学物质的异常导致了这些疾病的病因。我们的研究将检查这些化学物质（神经降压素和乙酰胆碱）在小肠和大肠中的作用位点（受体）。动物肠道对这些化学物质响应而产生的运动变化的机制已经进行了深入研究，但人类肠道的详细信息却很少。这项研究将深入了解正常肠道的运作机制，为比较 IBD 或 ICC 患者的肠道提供基础。我们还将研究急性憩室病 (DD) 手术中切除的肠道，这是另一种炎症类型。对 ICC 患者的孤立结肠段进行研究将确定肌肉收缩性是否总体异常或仅与所研究的化学物质有关。其他研究将调查肠道中发生的炎症过程以及这在 IBD 中是否有所不同。我们的工作将有助于了解肠道在健康和胃肠道疾病中的功能，并可能为 IBD 和 ICC 带来新的医学治疗方法。