Pilot Projects Program

试点项目计划 R&R其他项目信息 7.项目概要/摘要 试点项目计划的具体目标是：1）为概念验证和可行性提供支持 研究在翻译的发现，以改善和修复骨骼，软骨和关节健康，2）， 指导骨骼健康和修复领域的早期基础科学研究人员的发展 并利用他们获得大量校外资金的能力获得独立地位（NIH RO 1或 等效）作为结果指标，3）指导骨科的早期临床医生-科学家， 通过与基础科学的合作发展学术事业的流变学和相关领域 研究者利用他们作为合作研究者和主要研究者获得校外资金的能力， 一个结果测量。拟议的试点项目方案的重要性在于它与这一目标保持一致。 以大学为基础的战略计划，提供重点和资源的集合，将加速 发现与翻译我们将以创新的方式实现这些目标， 科学家和临床医生的协作团队，特别关注发现的转化策略 旨在改善和修复骨骼、软骨和关节健康。除了支持和促进 对改善和修复骨骼、软骨和关节健康的发现进行可行性研究， 我们将为基础科学家和临床科学家提供指导。这将是完成 通过直接指导和教学计划。试点项目本身将得到一个指导小组的支持。 理事会，将协助项目导师和协调整个计划的指导工作。考虑到高 由于第一及第二阶段的试验计划获得成功，我们对第三阶段的试验计划极感兴趣， 项目的终点是将发现转化为真实的世界， 帮助患者的诊断工具。

Pilot Projects Program R&R Other Project Info 7. Project Summary/Abstract The specific aims for the Pilot Projects Program are 1) to provide support for proof-of-concept and feasibility studies in the translation of discoveries for improving and repairing skeletal, cartilage and joint health, 2) to mentor early stage basic science investigators in the field of skeletal health and repair for their development and attainment of independent status using their ability to obtain significant extramural funding (NIH RO1 or equivalent) as an outcome measure, and 3) to mentor early stage clinician-scientists in orthopaedics and rheumatology and related fields for developing an academic career through collaborations with basic science investigators using their ability to obtain extramural funding as a Co-Investigator and Principal Investigator as an outcome measure. The significance of the proposed pilot projects program is its alignment with this University-based strategic plan providing focus and an aggregation of resources that will accelerate discoveries and translations. We will accomplish these aims with an innovative approach of fostering collaborative teams of scientists and clinicians with the specific focus on translational strategies for discoveries aimed at improving and repairing skeletal, cartilage and joint health. In addition to supporting and promoting feasibility studies in the translation of discoveries for improving and repairing skeletal, cartilage and joint health, we will provide mentoring for the both the basic scientists and clinician-scientists. This will be accomplished with direct mentoring and with a didactic program. The pilot program itself will be supported by a mentoring council that will assist project mentors and coordinate mentoring efforts across the program. Given the high success of the Pilot Projects supported under our Phase I & II, we are extremely enthusiastic the Phase III pilot projects endpoint on the continuum is the translation of discoveries into real world, marketable therapies or diagnostic tools that help patients.