Pilot Projects Program

试点项目计划 R&R 其他项目信息 7. 项目总结/摘要 试点项目计划的具体目标是 1) 为概念验证和可行性提供支持 将研究成果转化为改善和修复骨骼、软骨和关节健康的研究，2) 指导骨骼健康和修复领域的早期基础科学研究人员的发展 并利用其获得大量外部资金的能力（NIH RO1 或 同等）作为结果衡量标准，以及 3）指导骨科和骨科领域的早期临床医生科学家 风湿病学及相关领域通过与基础科学的合作发展学术生涯 研究人员利用他们作为联合研究员和首席研究员的能力获得外部资金 结果衡量标准。拟议试点项目计划的意义在于它与这一点保持一致 以大学为基础的战略计划提供重点和资源聚合，将加速 发现和翻译。我们将通过创新的方法来实现这些目标 由科学家和临床医生组成的协作团队，特别关注发现的转化策略 旨在改善和修复骨骼、软骨和关节健康。除了支持和推广 转化改善和修复骨骼、软骨和关节健康的发现的可行性研究， 我们将为基础科学家和临床科学家提供指导。这将实现 通过直接指导和教学计划。试点计划本身将得到指导的支持 委员会将协助项目导师并协调整个项目的指导工作。鉴于高 我们的第一阶段和第二阶段支持的试点项目取得了成功，我们对第三阶段试点项目非常热衷 连续体上的项目终点是将发现转化为现实世界、可销售的疗法或 帮助患者的诊断工具。

Pilot Projects Program R&R Other Project Info 7. Project Summary/Abstract The specific aims for the Pilot Projects Program are 1) to provide support for proof-of-concept and feasibility studies in the translation of discoveries for improving and repairing skeletal, cartilage and joint health, 2) to mentor early stage basic science investigators in the field of skeletal health and repair for their development and attainment of independent status using their ability to obtain significant extramural funding (NIH RO1 or equivalent) as an outcome measure, and 3) to mentor early stage clinician-scientists in orthopaedics and rheumatology and related fields for developing an academic career through collaborations with basic science investigators using their ability to obtain extramural funding as a Co-Investigator and Principal Investigator as an outcome measure. The significance of the proposed pilot projects program is its alignment with this University-based strategic plan providing focus and an aggregation of resources that will accelerate discoveries and translations. We will accomplish these aims with an innovative approach of fostering collaborative teams of scientists and clinicians with the specific focus on translational strategies for discoveries aimed at improving and repairing skeletal, cartilage and joint health. In addition to supporting and promoting feasibility studies in the translation of discoveries for improving and repairing skeletal, cartilage and joint health, we will provide mentoring for the both the basic scientists and clinician-scientists. This will be accomplished with direct mentoring and with a didactic program. The pilot program itself will be supported by a mentoring council that will assist project mentors and coordinate mentoring efforts across the program. Given the high success of the Pilot Projects supported under our Phase I & II, we are extremely enthusiastic the Phase III pilot projects endpoint on the continuum is the translation of discoveries into real world, marketable therapies or diagnostic tools that help patients.