Pilot Projects Program

试点项目计划 R&R其他项目信息 7.项目摘要/摘要 试点项目计划的具体目标是：1)为概念验证和可行性提供支持 将改善和修复骨骼、软骨和关节健康的发现转化为 指导骨骼健康和修复领域的早期基础科学研究人员的发展 以及利用他们获得大量外部资金的能力获得独立地位(NIH RO1或 等价物)作为结果衡量标准，以及3)指导早期临床医生-骨科科学家和 通过与基础科学的合作发展学术事业的风湿病及相关领域 调查员利用其作为联合调查员和首席调查员获得外部资金的能力 一种结果衡量标准。拟议的试点计划的意义在于它与以下内容相一致 以大学为基础的战略计划，提供重点和资源聚合，将加快 发现和翻译。我们将以创新的方式促进 科学家和临床医生的协作团队，专门关注发现的翻译策略 旨在改善和修复骨骼、软骨和关节健康。除了支持和促进 将改善和修复骨骼、软骨和关节健康的发现转化为可行性研究， 我们将为基础科学家和临床科学家提供指导。这将会实现的 通过直接指导和说教计划。试点计划本身将得到一名导师的支持 该委员会将协助项目导师并协调整个项目的指导工作。考虑到高价 第一阶段及第二阶段的试验计划成功，我们对第三阶段的试验计划非常热心。 连续统一体上的项目终点是将发现转化为现实世界、适销对路的疗法或 帮助病人的诊断工具。

Pilot Projects Program R&R Other Project Info 7. Project Summary/Abstract The specific aims for the Pilot Projects Program are 1) to provide support for proof-of-concept and feasibility studies in the translation of discoveries for improving and repairing skeletal, cartilage and joint health, 2) to mentor early stage basic science investigators in the field of skeletal health and repair for their development and attainment of independent status using their ability to obtain significant extramural funding (NIH RO1 or equivalent) as an outcome measure, and 3) to mentor early stage clinician-scientists in orthopaedics and rheumatology and related fields for developing an academic career through collaborations with basic science investigators using their ability to obtain extramural funding as a Co-Investigator and Principal Investigator as an outcome measure. The significance of the proposed pilot projects program is its alignment with this University-based strategic plan providing focus and an aggregation of resources that will accelerate discoveries and translations. We will accomplish these aims with an innovative approach of fostering collaborative teams of scientists and clinicians with the specific focus on translational strategies for discoveries aimed at improving and repairing skeletal, cartilage and joint health. In addition to supporting and promoting feasibility studies in the translation of discoveries for improving and repairing skeletal, cartilage and joint health, we will provide mentoring for the both the basic scientists and clinician-scientists. This will be accomplished with direct mentoring and with a didactic program. The pilot program itself will be supported by a mentoring council that will assist project mentors and coordinate mentoring efforts across the program. Given the high success of the Pilot Projects supported under our Phase I & II, we are extremely enthusiastic the Phase III pilot projects endpoint on the continuum is the translation of discoveries into real world, marketable therapies or diagnostic tools that help patients.