Strengthening the continuity of HIV care in Tanzania with economic support

通过经济支持加强坦桑尼亚艾滋病毒护理的连续性

• 批准号: 10838775
• 负责人: Sandra I McCoy
• 金额: $ 15.54万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10838775
• 关键词: Adherence; Adopted; Adoption; Africa South of the Sahara; Area; Authorization documentation; Automation; Award; Biometry; Caring; Clinic; Code; Collaborations; Collection; Communities; Community Health; Companions; Computer software; Custom; Data; Databases; Dependence; Development; Documentation; Economics; Environment; Evaluation; Event; Evidence based intervention; Fingerprint; Funding; Goals; HIV; Health; Health Priorities; Health Services; Health behavior; Health system; Human immunodeficiency virus test; Incentives; Knowledge Management; Laboratories; Left; Libraries; Life; Maintenance; Manuals; Methods; Modeling; Monitor; Operating System; Outcome; Parents; Participant; Patient Monitoring; Patient-Focused Outcomes; Patients; Performance; Persons; Process; Provider; Reaction Time; Registries; Reporting; Reproducibility; Research; Research Personnel; Resources; Risk; Running; Secure; Security; Site; Software Design; Software Engineering; Source Code; Standardization; System; Tanzania; Technology; Testing; Time; Update; Viral Load result; Visit; Work; Writing; application programming interface; authority; cluster trial; dashboard; data exchange; data format; design; eHealth; evidence base; financial incentive; implementation evaluation; improved; incentive program; innovation; mHealth; open data; open source; parallelization; parent project; payment; portability; programs; randomized trial; scale up; software development; software systems; tool; treatment adherence; usability; user-friendly

SUMMARY Financial incentives are an evidence-based intervention to improve engagement in beneficial health behaviors and services for many priority health issues. Our team has extensively studied the benefits of financial incentives for people living with HIV in Tanzania, including through the ongoing Rudi Kundini, Pamoja Kundini (R01MH125746) study. Research from our team and others reveals that financial incentives can increase HIV testing, enhance linkage to care, and bolster treatment adherence. Yet despite this evidence, few financial incentive programs have been scaled for HIV and other urgent health threats sub-Saharan Africa. One reason for this ‘know-do’ gap is that simplified, automated, and secure software for implementing incentive programs at scale have yet to be developed, evaluated, and shared. To meet this need, through collaboration with the Tanzanian Ministry of Health and the Tanzanian technology firm Rasello, we developed an innovative, acceptable, reliable, and scalable software (the “Rasello mHealth system”) to automate incentive distribution. The software securely sends incentives through mobile money, monitors HIV care with biometric identification, sends SMS visit and laboratory test reminders, and integrates with partner databases via application programming interfaces (API). Extensive stakeholder testing has permitted iterative improvement of the software to seamlessly incorporate into clinic workflows. The software is being used in the parent R01 (R01MH125746), but it was not designed to align with software engineering best practices, FAIR4RS principles, or principles of open science, which will limit its impact. Given that this was unforeseen when R01MH125746 was awarded, the Rasello mHealth system is the focus of this application. We will first enhance the system’s source code, improve documentation and version management, and adopt build/test tools for community open-source development (Aim 1). We will then develop standard build and packaging tools to manage the Rasello mHealth system’s dependencies, produce containerized runtimes, and containerize the software for a tool registry (Aim 2). We will also refactor the mHealth system software to incorporate standard interfaces and data formats and replace custom code with standard, hardened libraries where indicated (Aim 3). Lastly, we will improve performance of the Rasello mHealth system through improved logging, monitoring, code profiling and optimization; leveraging parallelization and GPUs (Aim 4). The Rasello mHealth system is a valuable resource for the scientific community, combining many desired features in a user-friendly platform to securely scale financial incentives for a variety of priority health issues. As we enter Year 3 of R01MH125746, now is the ideal time to enhance the system according to software engineering best practices and principles of open science, a need which was unanticipated when the parent study was funded. These activities will improve the impact and sustainability of the software to successfully complete the parent project and has potential to benefit the broader scientific community. 1

总结 经济激励是一种基于证据的干预措施，以改善对有益健康行为的参与 以及为许多优先健康问题提供服务。我们的团队已经广泛研究了金融的好处， 鼓励坦桑尼亚艾滋病毒感染者，包括通过正在进行的Rudi Kundini、Pamoja Kundini （R 01 MH 125746）研究。我们团队和其他人的研究表明，经济激励会增加艾滋病毒感染率。 检测，加强与护理的联系，并加强治疗依从性。然而，尽管有这些证据， 在撒哈拉以南非洲，针对艾滋病毒和其他紧急健康威胁的激励计划已经扩大规模。一个原因 这种“知道-做”的差距是，简化，自动化和安全的软件，用于实施激励计划 在规模上还有待开发、评估和共享。 为了满足这一需求，通过与坦桑尼亚卫生部和坦桑尼亚技术合作， Rasello公司开发了一种创新的、可接受的、可靠的且可扩展的软件（“Rasello mHealth 系统”）以自动化激励分配。该软件通过移动的货币安全地发送激励， 通过生物识别监测艾滋病毒护理，发送短信访问和实验室检测提醒， 通过应用程序编程接口（API）与合作伙伴数据库连接。广泛的利益相关者测试 允许软件的迭代改进，以无缝地整合到临床工作流程中。该软件 在父R 01（R 01 MH 125746）中使用，但其设计并非最符合软件工程 实践，FAIR 4 RS原则或开放科学原则，这将限制其影响。考虑到这是 R 01 MH 125746被授予时不可预见，Rasello mHealth系统是该应用的重点。 我们将首先增强系统的源代码，改进文档和版本管理，并采用 用于社区开源开发的构建/测试工具（目标1）。然后我们将开发标准构建， 打包工具来管理Rasello mHealth系统的依赖关系，生成容器化的运行时， 将软件容器化，用于工具注册表（目标2）。我们还将重构mHealth系统软件， 整合标准接口和数据格式，并使用标准的强化库替换自定义代码 （目标3）。最后，我们将通过改进Rasello mHealth系统来提高其性能。 日志记录、监控、代码分析和优化;利用并行化和GPU（目标4）。 Rasello mHealth系统是科学界的宝贵资源，结合了许多期望的 在一个用户友好的平台上提供功能，以安全地扩展针对各种优先健康问题的财务激励措施。 随着我们进入R 01 MH 125746的第3年，现在是根据软件增强系统的理想时机 工程最佳实践和开放科学的原则，这是一个需要，这是没有预料到的，当家长 研究得到资助。这些活动将提高软件的影响力和可持续性， 完成母项目，并有可能使更广泛的科学界受益。 1

项目成果

Rudi Kundini, Pamoja Kundini (RKPK): study protocol for a hybrid type 1 randomized effectiveness-implementation trial using data science and economic incentive strategies to strengthen the continuity of care among people living with HIV in Tanzania.

Rudi Kundini、Pamoja Kundini (RKPK)：一项混合 1 型随机有效性实施试验的研究方案，利用数据科学和经济激励策略来加强坦桑尼亚艾滋病毒感染者护理的连续性。

• DOI: 10.21203/rs.3.rs-3315136/v1
• 发表时间: 2023
• 期刊: Research square
• 作者: Kadota,JillianL;Packel,LauraJ;Mlowe,Matilda;Ulenga,Nzovu;Mwenda,Natalino;Njau,ProsperF;Dow,WilliamH;Wang,Jingshen;Sabasaba,Amon;McCoy,SandraI
• 通讯作者: McCoy,SandraI

Efficient targeted learning of heterogeneous treatment effects for multiple subgroups.

有效有针对性地学习多个亚组的异质治疗效果。

• DOI: 10.1111/biom.13800
• 发表时间: 2023
• 期刊: Biometrics
• 影响因子: 1.9
• 作者: Wei,Waverly;Petersen,Maya;vanderLaan,MarkJ;Zheng,Zeyu;Wu,Chong;Wang,Jingshen
• 通讯作者: Wang,Jingshen