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Interrogating the cholinergic basis of opioid use disorder

探究阿片类药物使用障碍的胆碱能基础

基本信息

批准号：
10839681
负责人：
Michael R Tadross
金额：
$ 8.57万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-06-01 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10839681
关键词：
Acetylcholine Action Potentials Acute Address Affect Analgesics Animals Behavior Behavior Disorders Behavioral Brain Cells Clinical Complex Data Development Dopamine Electrophysiology (science)Environment Epidemic Fiber Fostering Future Goals Interneurons Intervention Learning Maps Measurement Measures Mediating Methods Morphine Mus Naloxone Neuromodulator Neuropharmacology Nucleus Accumbens Opioid Opioid Antagonist Opioid Receptor Optics Pain Pain management Parents Pharmaceutical Preparations Pharmacology Phase Photometry Population Positioning Attribute Property Proxy Psychological reinforcement Reagent Research Rest Role Signal Transduction Specificity Surface System Techniques Technology Testing Therapeutic Therapeutic Intervention Viral Vector Work antagonist behavioral study cell type cholinergic clinical efficacy dopaminergic neuron experimental study graduate student insight millisecond mouse model neural neuroregulation novel therapeutic intervention opioid use opioid use disorder parent grant personalized intervention role model sensor side effect temporal measurement tool

项目摘要

ABSTRACT: Diversity Supplement, Interrogating the Cholinergic Basis of Opioid Use Disorder Opioids offer unmatched clinical efficacy in the treatment of pain, yet produce equally harmful side effects that can lead to opioid use disorder. Because traditional drugs impact all cells in a given volume, it has been difficult to map cell type-specific contributions of drug-mediated behavior. To address this gap, we developed an opioid- DART toolset, which makes it possible to deliver clinical opioids to genetically defined cells in behaving mice. In our parent grant, we are now testing the hypothesis that opioid receptors on cholinergic interneurons mediate the harmful (addictive) effects of opioids, independent of helpful (analgesic) effects. This Diversity Supplement supports Lailah Ligons, a rising second-year graduate student, who will examine the cholinergic basis of opioid use disorder with a focus on neural recording. In line with the parent proposal, Lailah's research will involve employing DART technology and behavioral experiments. By focusing on neural recording, her work will provide valuable insights into cell type-specific opioid effects and their impacts on neural activity. Ultimately, this research will contribute to the development of novel therapeutic strategies and further our understanding of the complex interplay between opioids and the brain. Moreover, by promoting diversity in the field of opioid neuropharmacology, this supplement fosters an inclusive research environment and sets the stage for Ms. Ligons to become a role model and future leader in the field.

摘要：多样性补充，探讨阿片类药物使用障碍的胆碱能基础