Investigating obesity-induced altered ovarian intracellular signaling
Investigating obesity-induced altered ovarian intracellular signaling
批准号:
10837744
负责人:
Aileen Frances Keating
金额:
$10.04万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
已结题
起止时间:
2020-01-01 至 2024-10-31
关键词:
AHR geneATM activationAccelerationAddressAffectAnthracenesAntioxidantsAreaAromatic Polycyclic HydrocarbonsBiologyChIP-seqChemical ExposureChemicalsConceptionsCongenital AbnormalityDNA AdductionDNA AdductsDNA DamageDNA RepairDNA Repair GeneDataDevelopmentDietEnzymesEstrusEventExposure toFamily suidaeFatty acid glycerol estersFemaleFertilityFoundationsFrequenciesFunctional disorderFutureGenerationsGoalsHealthHeat Stress DisordersHyperinsulinismHyperphagiaInfertilityInvestigationLearningLongevityMaintenanceMalignant neoplasm of ovaryMetabolicMetabolic BiotransformationMethylationMinorityMinority GroupsMinority WomenModelingMusNeonatalObese MiceObesityOutcomeOvarianOvarian FollicleOvaryOxidative StressOxidative Stress InductionPIK3CG genePathway interactionsPeriodicityPhenotypePositioning AttributeProteinsPublicationsReactive Oxygen SpeciesReproductionReproductive HealthResearchRiskRoleSignal TransductionSocietiesSolidSpecific qualifier valueSpontaneous abortionStressSubfecundityThinnessWomanWomen&aposs HealthWorkataxia telangiectasia mutated proteinclimate changeclimate-related healthdimethylbenzanthracenefeedingfemale fertilitygirlshealth equityhistone modificationimplantationimprovedin uterointerestmouse modelnoveloffspringoocyte qualityovarian damageovotoxicantovotoxicityprepubertypromoterreproductivereproductive successresponserisk minimizationsocioeconomicsstressorsugartooltranscriptome sequencing
中文摘要
摘要:提出的研究是关于气候变化对健康的影响,特别是与女性有关
英文摘要
Abstract: The research proposed is on Health Effects of climate change, specifically related to female
reproductive and general health, in lean and obese females. Since obesity affects ~40% of women, and
disproportionately impacts minority girls and women, this proposal is relevant to the Health Equity aspects of the
climate change and health initiative. This work addresses \ the identified relevant areas of understanding the
effects of climate-change-induced stress on reproduction and development and assesses multiple chemical
(DMBA) and non-chemical stressors (obesity and heat stress) across the lifespan. Climate change and
accompanying frequency of severe HS events is unabating, thus, understanding impacts of HS on ovarian
function is desperately needed. Dr. Keating is uniquely positioned for this study due to her scientific record in
this area of ovarian biology (twenty publications on heat stress biology with the majority related to
reproduction) and the technical feasibility to conduct these studies. The hypothesis is that heat stress will cause
hyperinsulinemia, altering ovarian steroidogenic, DNA repair, oxidative stress and chemical
biotransformation protein abundance, accelerating ovarian toxicity during DMBA exposure, and this will
be heightened in obese relative to lean mice. This hypothesis is based upon our strong preliminary data in
female pig biomedical models and the relevance to the metabolic changes observed during obesity. This
supplement will generate data to pave the way for future exploration into the additive impact of heat stress on
ovotoxicity using tractable mouse models to delve into specific pathways.
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Investigating obesity-induced altered ovarian intracellular signaling
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批准号:10318369
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项目类别:
-
资助金额:$3.26万
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财政年份:2021
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负责人:Aileen Frances Keating
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依托单位:
Investigating obesity-induced altered ovarian intracellular signaling
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批准号:10725958
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项目类别:
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资助金额:$6.89万
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财政年份:2020
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负责人:Aileen Frances Keating
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依托单位:
Investigating obesity-induced altered ovarian intracellular signaling
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批准号:10292981
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项目类别:
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资助金额:$50.52万
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财政年份:2020
-
负责人:Aileen Frances Keating
-
依托单位:
Investigating obesity-induced altered ovarian intracellular signaling
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批准号:10516909
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项目类别:
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资助金额:$6.53万
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财政年份:2020
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负责人:Aileen Frances Keating
-
依托单位:
Investigating obesity-induced altered ovarian intracellular signaling
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批准号:10521241
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项目类别:
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资助金额:$49.5万
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财政年份:2020
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负责人:Aileen Frances Keating
-
依托单位:
Investigating obesity-induced altered ovarian intracellular signaling
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批准号:9887875
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项目类别:
-
资助金额:$45.97万
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财政年份:2020
-
负责人:Aileen Frances Keating
-
依托单位:
Investigating obesity-induced altered ovarian intracellular signaling
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批准号:10725953
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项目类别:
-
资助金额:$6.53万
-
财政年份:2020
-
负责人:Aileen Frances Keating
-
依托单位:
Investigating obesity-induced altered ovarian intracellular signaling
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批准号:10531681
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项目类别:
-
资助金额:$5.32万
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财政年份:2020
-
负责人:Aileen Frances Keating
-
依托单位:
Investigating modes of action of glyphosate-induced ovotoxicity
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批准号:9182466
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项目类别:
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资助金额:$22.5万
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财政年份:2016
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负责人:Aileen Frances Keating
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依托单位:
Glutathione S-Tranferase signaling in VCD-induced ovotoxicity.
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批准号:8272625
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项目类别:
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资助金额:$24.9万
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财政年份:2010
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负责人:Aileen Frances Keating
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依托单位:
Glutathione S-Tranferase signaling in VCD-induced ovotoxicity.
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批准号:8071205
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项目类别:
-
资助金额:$24.9万
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财政年份:2010
-
负责人:Aileen Frances Keating
-
依托单位:
Glutathione S-Tranferase signaling in VCD-induced ovotoxicity.
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批准号:8042877
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项目类别:
-
资助金额:$24.9万
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财政年份:2010
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负责人:Aileen Frances Keating
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依托单位:
Glutathione S-Tranferase signaling in VCD-induced ovotoxicity.
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批准号:7661866
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项目类别:
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资助金额:$9.0万
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财政年份:2009
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负责人:Aileen Frances Keating
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依托单位:
海外基金