ATM Activation and its functional Importance in DNA damage response
ATM Activation and its functional Importance in DNA damage response
批准号:
nhmrc : 569591
负责人:
Dr Mark Graham
金额:
$37.04万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2009
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2009-01-01 至 2011-12-31
中文摘要
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英文摘要
ATM is the protein deficient in the human genetic disorder ataxia-telangiectasia (A-T). This syndrome is characterised by neurodegeneration and increased risk of cancer. ATM recognises damage in DNA and facilitates its repair to minimize the risk of genetic defects. The project is designed to investigate the mechanism of activation of ATM. This information is important to understand the role of ATM in preventing cancer.
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