Frailty, Aging, and Risk of Adverse Outcomes in Mitral Valve Prolapse (FAR-OUT-MVP Study)
Frailty, Aging, and Risk of Adverse Outcomes in Mitral Valve Prolapse (FAR-OUT-MVP Study)
批准号:
10836297
负责人:
Jordan Blair Strom
金额:
$17.28万
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-07-01 至 2024-06-30
关键词:
Accident and Emergency departmentAdverse eventAgeAgingArrhythmiaAtrial FibrillationAttenuatedBenignBlood flowCardiacCardiovascular systemCase MixesCommunitiesDataData LinkagesData SetData SourcesDatabasesDecision MakingDevelopmentDiseaseEchocardiographyEmployeeEndocarditisEnrollmentEventFibrosisFutureGeneral PopulationHeart Valve DiseasesHeart failureHeterogeneityHomeostasisImageImpairmentImplantable DefibrillatorsIndividualInpatientsInstitutionInsuranceInvestigationIsraelLeftLinkMagnetic ResonanceMassachusettsMedical centerMitral ValveMitral Valve InsufficiencyMitral Valve ProlapseMorbidity - disease rateMyocardialMyocardial ContractionNational Heart, Lung, and Blood InstituteNatural HistoryOutcomeOutpatientsPatientsPhenotypePhysiologicalPopulationPrevalencePrivatizationPrognosisProviderRegistriesReportingRiskRisk FactorsRoleRuptureSecondary toSeveritiesStressful EventStretchingStructureSurvivorsSystemTissuesVentricularVentricular ArrhythmiaVulnerable Populationsadverse event riskadverse outcomeaortic valve disordercardiac magnetic resonance imagingcardiovascular risk factorcerebrovascularclinically relevantcohortfrailtyheart imaginghigh riskhuman old age (65+)imaging biomarkerimprovedinsightmitral valve replacementmortalitymortality risknovelpapillary musclerepairedstressorstructured datasudden cardiac death
中文摘要
项目总结
英文摘要
PROJECT SUMMARY
Mitral valve prolapse (MVP) is a common cardiac valvular disease, with a prevalence of roughly 2-3% in the
general population, associated with excess mitral valve or chordal tissue may predispose to the development
of mitral regurgitation (MR) from leaflet malcoaptation and chordal rupture. This condition and its sequelae,
detected on echocardiograms (TTEs) and cardiac magnetic resonance images (CMRs), has been previously
felt to be associated with an overall benign prognosis. Recent evidence suggest a subset of individuals with
MVP have an excess risk of cardiovascular and non-cardiovascular morbidity and mortality, including
ventricular arrhythmias and sudden cardiac death. Despite known risks of MVP, it remains challenging to
identify high risk subsets in need of further treatments such as implantable defibrillator use or mitral
valve repair or replacement. Furthermore, disaggregating the risk of MVP from that of concomitant MR
remains challenging at present. Moreover, while individual imaging biomarkers of risk have been identified,
which of these independently influence MVP risk when considered together remains unclear. While relevant
clinical risk factors including aging and frailty, “a state of increased vulnerability and reduced ability to maintain
homeostasis after a stressful event resulting from an impairment in multiple physiologic systems,” have found
to influence outcome risk in other valvular heart diseases, it remains unclear if aging and frailty modify the risk
of MVP on adverse outcomes. This proposal leverages the unique linkage of two large data sources,
structured datasets of TTE and CMR reports from Beth Israel Deaconess Medical Center, and all-payer
statewide claims data from the Massachusetts Case Mix Dataset (MACM) to better evaluate the risk of MVP
across the spectrum of age and frailty. In this study, we propose to directly link BIDMC TTE and CMR reports
to MACM data to evaluate whether MVP is associated with a risk of mortality, cardiovascular morbidity
(composite of heart failure, atrial fibrillation, cerebrovascular event, endocarditis), and need for mitral valve
replacement or repair, and whether this risk relationship varies by age and frailty as well as operative status
(receipt of mitral valve replacement or repair). Doing so, this study will provide greater insight into the
role that aging and frailty may have on the risk of serious outcomes associated with MVP and build a
unique registry of cardiac imaging information linked to outcome data that could be leveraged in the
future to deepen understanding of MVP as well as other valvular heart diseases.
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DOI:
10.1136/openhrt-2021-001743
发表时间:
2022-01
期刊:
Open heart
影响因子:
2.7
作者:
[Pankayatselvan V, Raber I, Playford D, Stewart S, Strange G, Strom JB]
通讯作者:
Strom JB
Echocardiographic Progression of Peak Tricuspid Regurgitant Velocity Among Medicare Beneficiaries.
医疗保险受益人三尖瓣反流峰值速度的超声心动图进展。
DOI:
10.1016/j.jacadv.2023.100579
发表时间:
2023
期刊:
JACC. Advances
影响因子:
--
作者:
[Kholdani,CyrusA, Choudhary,Gaurav, Furfaro,DavidM, Markson,LawrenceJ, Manning,WarrenJ, Strom,JordanB]
通讯作者:
Strom,JordanB
DOI:
10.1016/j.echo.2021.08.011
发表时间:
2021-11
期刊:
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography
影响因子:
--
作者:
[Fostello SE, Stout JL, Manning WJ, Strom JB]
通讯作者:
Strom JB
DOI:
10.1371/journal.pone.0244379
发表时间:
2020
期刊:
PloS one
影响因子:
3.7
作者:
[Hammond MM, Shen C, Li S, Kazi DS, Sabe MA, Garan AR, Markson LJ, Manning WJ, Klein AL, Nagueh SF, Strom JB]
通讯作者:
Strom JB
Race, sex and age disparities in echocardiography among Medicare beneficiaries in an integrated healthcare system.
综合医疗保健系统中医疗保险受益人超声心动图的种族,性别和年龄差异。
DOI:
10.1136/heartjnl-2021-319951
发表时间:
2022-05-25
期刊:
HEART
影响因子:
5.7
作者:
[Hyland, Patrick M., Xu, Jiaman, Shen, Changyu, Markson, Lawrence J., Manning, Warren J., Strom, Jordan B.]
通讯作者:
Strom, Jordan B.
共 21 条
Chronic Renal Insufficiency and Silent Progression of Aortic Stenosis (CRISP-AS)
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批准号:10718275
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项目类别:
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资助金额:$87.14万
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财政年份:2023
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负责人:Jordan Blair Strom
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依托单位:
Identification of the Components of Frailty Using Administrative Data and Metabolite Profiling
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批准号:10441266
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项目类别:
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资助金额:$17.28万
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财政年份:2019
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负责人:Jordan Blair Strom
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依托单位:
Identification of the Components of Frailty Using Administrative Data and Metabolite Profiling
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批准号:10217235
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项目类别:
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资助金额:$17.28万
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财政年份:2019
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负责人:Jordan Blair Strom
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依托单位:
Identification of the Components of Frailty Using Administrative Data and Metabolite Profiling
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批准号:10657394
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项目类别:
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资助金额:$17.28万
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财政年份:2019
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负责人:Jordan Blair Strom
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依托单位:
海外基金