Alzheimers Disease Patient Registry (Administrative Supplement)

项目摘要 这项行政补充请求是为了加强梅奥老年诊所研究的工作 (MCSA)在明尼阿波利斯和明尼苏达州圣保罗这两个孪生城市增加了一个新的非裔美国人队列。 MCSA是明尼苏达州奥姆斯特德县一项以人口为基础的认知和老龄化研究。确实是 成立于2004年，现有6,000多人，拥有约3,000人的活跃队列和 出版了200多篇关于衰老、认知和阿尔茨海默病(AD)的出版物。而当 MCSA成功地实现了其目标，将MCSA的调查结果推广到更具种族色彩的 种族多元化的人口也很有限，因为奥姆斯特德县82.5%的地区是白人。具体的 MCSA当前赠款周期的目标1和2正在评估2018年NIA-AA研究框架，以 广告。具体目标3评估脑血管疾病(CVD)在人群中的作用 SPECTRUM高级MRI措施，特定目标4是测量血浆生物标记物对 AD和普通人群中的神经退行性变。我们一直在与 伯曼亨内平医疗研究中心，并通过梅奥的慈善赠款 诊所、伯曼中心及其社区参与合作伙伴已经启动了基础设施 发展招募一批非裔美国人。拟议的研究将是 一项模仿MCSA的纵向观察性研究，用于测量认知、身体功能和 一般健康，特别强调心血管健康。之前的美国流行病学研究 其他地方的报告称，非裔美国人患痴呆症的比例高于白人。这些 老年黑人和白人之间AD和阿尔茨海默病相关痴呆(ADRD)风险的差异 美国的人口可以用社会经济因素、生活经历和 一生中的慢性疾病--尤其是糖尿病和心脑血管疾病 疾病--这种疾病与痴呆症风险更高有关，在非裔美国人中更普遍。我们的 拟议的试点研究将从双城招募85名年龄在55岁至90岁之间的非洲裔美国人，以 接受临床评估，广泛的健康史，提供血液样本，并参与核磁共振 使用MCSA协议的研究。梅奥诊所将对血浆样本进行AD生物标志物评估 和其他炎症性风险因素。我们预计这一试点队列的发展将提供 在双子城发展更大的非裔美国人队列的宝贵经验。通过将 MCSA团队和明尼阿波利斯的伯曼中心的专业知识，这是一个巨大的机会 在城市非裔美国双子城社区中提高大脑健康的知识。

Project Summary This administrative supplement request is to augment the work of the Mayo Clinic Study of Aging (MCSA) by adding a new African American cohort in the Twin Cities of Minneapolis and St. Paul, MN. The MCSA is a population-based study of cognition and aging in Olmsted County, Minnesota. It was established in 2004, seen over 6,000 persons, keeps an active cohort of about 3,000 individuals and generated over 200 publications pertaining to aging, cognition, and Alzheimer’s disease (AD). While the MCSA has been successful in pursuing its Aims, the generalizability of the MCSA findings to more racially and ethnically diverse populations has been limited, as 82.5% of Olmsted County is White. The Specific Aims 1 and 2 of the MCSA current grant cycle are evaluating the 2018 NIA-AA Research Framework for AD. Specific Aim 3 is assessing the role of cerebrovascular disease (CVD) in the population using broad spectrum advanced MRI measures, and Specific Aim 4 is measuring the utility of plasma biomarkers for AD and neurodegeneration in the general population. We have been working with colleagues at the Berman Center of the Hennepin Healthcare Research and through a philanthropic grant from the Mayo Clinic, the Berman Center and its Community Engagement partners have initiated the infrastructure development for the recruitment of a cohort of African American individuals. The proposed study will be a longitudinal observational study modeled after the MCSA to measure cognition, physical function and general health, with a particular emphasis on cardiovascular health. Previous US epidemiological studies elsewhere have reported that African Americans have a higher rate of dementia than Whites. These differences in AD and Alzheimer’s disease-related dementias (ADRD) risk between older Black and White populations in the US could be explained by disparities in socioeconomic factors, life experiences and chronic conditions across the life-course - especially diabetes and cardiovascular/ cerebrovascular disease - which are associated with higher dementia risk, and more prevalent in African Americans. Our proposed pilot study will recruit 85 African American individuals ages 55 to 90 from the Twin Cities to receive clinical evaluations, extensive health histories, provide blood samples and participate in MRI studies using MCSA protocols. Plasma samples will be evaluated at the Mayo Clinic for AD biomarkers and other inflammatory risk factors. We anticipate the development of this pilot cohort will provide valuable experience for developing a larger African American cohort in the Twin Cities. By combining the expertise of the MCSA team and the Berman Center in Minneapolis, this is a tremendous opportunity to advance knowledge of brain health in the urban African American Twin Cities community.