Nicaraguan Emerging and Endemic Diseases (NEED) Training Program

尼加拉瓜新发和地方病 (NEED) 培训计划

• 批准号: 10879929
• 负责人: Sylvia Irene Becker-Dreps
• 金额: $ 13.64万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10879929
• 关键词: Accreditation; Address; Administrative Supplement; Affect; Award; COVID-19 pandemic; Calicivirus; Caribbean region; Central America; Chikungunya virus; Childhood; Communicable Diseases; Costa Rica; Country; Dengue; Diarrhea; Disease Outbreaks; Doctor of Philosophy; Endemic Diseases; Enrollment; Ensure; Event; Faculty; Fostering; Funding; Goals; Growth; Individual; Infectious Disease Epidemiology; Infectious Diseases Research; Influenza; Investments; Latin America; Microbiology; Morbidity - disease rate; Nicaragua; Nicaraguan; Pattern; Politics; Prevalence; Public Health; Research; Research Personnel; Respiratory Disease; Respiratory syncytial virus; Risk; Science; Scientist; Serotyping; Training; Training Programs; Translating; Universities; Viral Epidemiology; Virus; Virus Diseases; Yellow fever virus; Zika Virus; biomedical scientist; burden of illness; cohort; design; doctoral student; evidence base; experience; innovation; mortality; pathogen; pathogenic virus; population health; pre-doctoral; programs; severe COVID-19; skill acquisition; skills; success

ABSTRACT The growing, global impact of emerging and endemic viral diseases is a critical public health issue. The explosive spread of Zika virus throughout Latin America and the Caribbean in 2015 followed only two years after a similar pattern of spread of chikungunya virus. In 2017, yellow fever virus from Amazon regions emerged in Rio de Janeiro, underscoring the risk of a major urban outbreak, and in 2020 the entire world were affected by the SARS-CoV-2 pandemic. In addition to these emerging and reemerging viruses, endemic viruses continue to cause a high burden of disease. Caliciviruses are now the leading causes of childhood diarrhea in Nicaragua, influenza and respiratory syncytial virus continue to cause a high burden of respiratory disease, and all four dengue serotypes are now endemic. We have designed a program to train a cadre of innovative Nicaraguan scientists to confront these emerging and endemic pathogens of high priority. The rationale for this program is to protect the public health of populations by increasing the numbers and expertise of local scientists to 1) describe the epidemiology of these viral pathogens, 2) understand their impact on morbidity and mortality, and 3) identify evidence-based approaches to reduce their prevalence and burden of disease. Our program’s original objectives included: 1) Provide long-term, pre-doctoral training in infectious disease epidemiology at UNC to two young investigators from UNAN-León. These graduates will contribute to infectious disease research in the region to address pressing local research agendas; 2) Create a sustainable supply of well-trained biomedical scientists in the region by establishing an accredited PhD program in Biomedical Sciences at UNAN-León; we will enroll five pre-doctoral candidates in the initial cohort. This program built upon a successful Master’s program of Microbiology in place at UNAN-León and fills a huge need in the region for PhD- trained infectious disease investigators. 3) Foster professional growth and research skills development among 140 trainees of all levels, including local faculty, to ensure academic and research success. Robust short-term trainings in professional and research skills needed to become an independent investigator and successful academician were provided to both trainees and local faculty to ensure that the program’s impacts extend more broadly. Unfortunate political events in Nicaragua during the final year of our award have forced us to adapt our second objective, as we are no longer able to partner with UNAN-León. Our 3 Biomedical Sciences PhD students need to complete their PhD training outside the country. The goal of this Administrative Supplement is to fund their training with experienced microbiology faculty at the University of Costa Rica, one of the only universities in the region to provide PhD training. We also request an additional year of funding for a trainee whose PhD training was delayed due to severe COVID. This will ensure that the investment made in these individuals translates into the completion of their PhD training and the increase in infectious disease research capacity in Central America.

抽象的 新兴和内在病毒疾病的日益增长的全球影响是一个关键的公共卫生问题。爆炸性 Zika病毒在2015年在拉丁美洲和加勒比海地区的传播之后仅两年 基孔肯雅病毒的传播模式。 2017年，亚马逊地区的黄热病病毒出现在里约热内卢 Janeiro强调了大城市爆发的风险，在2020年，全世界受到了影响 SARS-COV-2大流行。除了这些新兴和重新出现的病毒外，内在病毒还继续 清囊病现在是尼加拉瓜儿童腹泻的主要原因， 流感和呼吸道综合病毒继续引起高呼吸道疾病的燃烧，这四种 登革热血清型现在是地方性的。我们设计了一个计划来培训创新的尼加拉瓜干部 科学家面对这些高优先级的新兴和内在病原体。该程序的理由是 通过将当地科学家的数量和专业知识增加到1来保护人口的公共健康 描述这些病毒病原体的流行病学，2）了解它们对发病率和死亡率的影响，以及 3）确定基于证据的方法来减少其疾病的患病率和燃烧。我们的计划的原始内容 目标包括：1）在UNC的传染病流行病学中提供长期的，博士后的培训 给Unan-León的两名年轻调查员。这些毕业生将有助于传染病研究 在该地区解决当地研究议程； 2）创造可持续训练的可持续供应 该地区的生物医学科学家通过建立生物医学科学认可的博士学位计划 在Unan-León；我们将在初始队列中注册五名博士前候选者。这个程序建立在 成功在Unan-León制定了成功的微生物学计划，并满足了该地区的巨大需求。 受过训练的传染病研究人员。 3）促进专业成长和研究技能发展 在包括当地教职员工在内的所有级别的140名学员中，以确保学术和研究成功。 在专业和研究技能方面的强大短期培训需要成为独立研究者 并向学员和地方教师提供成功的院士，以确保该计划的影响 扩展更广泛。在我们奖励的最后一年，尼加拉瓜的不幸政治事件已经 迫使我们适应第二个目标，因为我们不再能够与Unan-León合作。我们的3 生物医学博士生需要在国外完成博士学位培训。目标 这种行政补充是为他们的培训提供经验的经验微生物学院 哥斯达黎加大学，该地区仅有的大学提供博士培训的大学之一。我们也是 要求额外的一年资金给学员，其博士学位培训由于严重的竞争而被推迟。 这将确保这些人的投资转化为其博士学位 培训和中美洲传染病研究能力的提高。