Administration and Coordination Core

行政和协调核心：项目摘要 西北大学癌症染色质纳米成像中心（NU-CCNIC）将为 来自罗伯特H. Lurie综合癌症中心 范伯格医学院和世界著名的成像和分子建模专家从 麦考密克工程学院的目标是促进创新和尖端成像的应用 技术，以帮助解决癌症生物学研究中一些最紧迫的问题。行政 协调核心（ACC）将由PI Vadim Backman领导。NU-CCNIC的日常管理 将由中心管理员管理，他将负责维护与此相关的所有记录。 奖励并确保NU-CCNIC之间的沟通、协同和资源共享。此外，中心 管理将由项目经理提供支持，项目经理将与中心管理员合作， 负责开发NU-CCNIC网站，安排会议和活动，促进 资源共享，确定是否将在NU-CCNIC之间共享出版前数据，以及 帮助进行有关数据质量控制、交叉验证和再现性的对话。外部咨询小组 (EAP)将成立，汇集研究人员与癌症干细胞可塑性相关领域的专业知识， 和染色质纳米成像。EAP被设想为一组高度活跃的成员， NU-CCNIC在科学指导和审查进展评估、研究战略和 实施，领导和传播，所有这些都是为了最大限度地发挥NU-CCNIC的影响。的 NU-CCNIC将通过聘请癌症专家来提高其研究的转化价值和潜在影响。 研究倡导者，他将是EAP的成员，并将应邀参加NU-CCNIC研讨会， 实地考察。ACC将支持每周、每两周、每月和每季度的研究会议， 通信，合作和NU-CCNIC的整合，并将进一步支持通信和广泛的， 通过一年两次的外部演讲者讲习班传播知识。在目标1中， 行政核心将促进和确保整个技术部门之间清晰有效的沟通 开发（TECH）和研究试验台（RTB）单位。在目标2中，我们将规划和建立常规中心 会议和研究研讨会，以促进NU-CCNIC内部和更广泛的社区的沟通 这对我们的研究使命和传播至关重要。在目标3中，我们将努力增加代表性， 培训NU-CCNIC生物医学研究队伍中代表性不足的少数民族。在目标4中，我们 与癌症研究倡导者合作，以确保患者观点在NU中的至关重要性- CCNIC。在目标5中，我们将与EAP和癌症研究倡导者合作开展NU-CCNIC评估项目 确保中心的进度及时完成，并合理分配资源。

Administrative and Coordination Core: PROJECT SUMMARY The proposed Northwestern University Center for Chromatin NanoImaging in Cancer (NU-CCNIC) will bring together leading cancer research biologists from the Robert H. Lurie Comprehensive Cancer Center in the Feinberg School of Medicine and world-renowned imaging and molecular modeling specialists from the McCormick School of Engineering with the goal of facilitating innovation and application of cutting-edge imaging techniques to help solve some of the most pressing problems in cancer biology research. The Administrative and Coordination Core (ACC) will be led by PI Vadim Backman. The day-to-day administration of the NU-CCNIC will be managed by the Center Administrator, who will be responsible for maintaining all records relative to this award and ensuring communication, synergy, and resource sharing across the NU-CCNIC. Additionally, Center administration will be supported by a Program Manager, who, in collaboration with the Center Administrator, will be responsible for the development of the NU-CCNIC website, scheduling meetings and events, facilitating the sharing of resources, determine whether there will be pre-publication data sharing across the NU-CCNIC, and aid in conversations about data quality control, cross validation, and reproducibility. An External Advisory Panel (EAP) will be formed, bringing together investigators with expertise in fields related to cancer stem cell plasticity and chromatin nanoimaging. The EAP is envisioned as a group of highly active members engaged to advise the NU-CCNIC leadership on scientific direction and review progress evaluation, research strategies and implementation, leadership and dissemination, all in the effort to maximize the impact of the NU-CCNIC. The NU-CCNIC will enhance the translational value and potential impact of its research by engaging a Cancer Research Advocate, who will be a member of the EAP and will be invited to attend NU-CCNIC workshops and site visits. The ACC will support weekly, bi-weekly, monthly, and quarterly research meetings to foster communication, collaboration and integration of the NU-CCNIC and will further support communication and wide- reaching knowledge dissemination through bi-annual workshops with outside speakers. In Aim 1, the Administrative Core will promote and ensure clear and effective communication across the Technology Development (TECH) and Research Test-Bed (RTB) Units. In Aim 2, we will plan and establish regular Center meetings and research workshops to foster communications within the NU-CCNIC and to the broader community that are critical to our research mission and dissemination. In Aim 3, we will work to increase representation and training of underrepresented minorities in the biomedical research workforce of the NU-CCNIC. In Aim 4, we will partner with the cancer research advocate to ensure the critical importance of the patient perspective in the NU- CCNIC. In Aim 5, we will work with the EAP and Cancer Research Advocate on NU-CCNIC evaluation programs to ensure Center progress is accomplished on a timely basis and that resources are allocated judiciously.