Administration and Coordination Core

行政和协调核心：项目摘要 拟议的西北大学癌症染色质纳米成像中心(NU-CCNIC)将带来 来自罗伯特·H·卢里综合癌症中心的领先癌症研究生物学家在一起 范伯格医学院和世界知名的成像和分子建模专家 麦考密克工程学院，目标是促进尖端成像的创新和应用 帮助解决癌症生物学研究中一些最紧迫的问题的技术。行政部门 协调核心(ACC)将由皮瓦迪姆·贝克曼领导。NU-CCNIC的日常管理 将由中心管理员管理，负责维护与此相关的所有记录 奖励，并确保整个NU-CCNIC的沟通、协同和资源共享。此外，居中 管理将由一名项目经理提供支持，项目经理将与中心管理员合作， 负责NU-CCNIC网站的开发，安排会议和活动，促进 资源共享，确定是否将在NU-CCNIC之间共享发布前数据，以及 协助就数据质量控制、交叉验证和可重复性进行对话。外部咨询小组 (EAP)将成立，将拥有癌症干细胞可塑性相关领域专业知识的研究人员聚集在一起 染色质纳米成像。EAP被设想为一组高度活跃的成员，负责为 NU-CCNIC在科学指导和审查进展评估、研究战略和 执行、领导和传播，所有这些都是为了最大限度地发挥NU-CCNIC的影响。这个 NU-CCNIC将通过参与癌症来增强其研究的翻译价值和潜在影响 研究倡导者，他将是EAP的成员，并将被邀请参加NU-CCNIC研讨会和 实地考察。行政协调会将支持每周、每两周、每月和每季度召开研究会议，以促进 NU-CCNIC的沟通、协作和整合，并将进一步支持沟通和广泛的 通过与外部发言者举行的两年一次的讲习班传播知识。在目标1中， 管理核心将促进和确保在整个技术领域进行清晰有效的沟通 开发(技术)和研究试验台(RTB)单位。在目标2中，我们将规划和建立常规中心 会议和研究讲习班，以促进国家核不扩散中心内部和与更广泛社区的交流 这对我们的研究任务和传播至关重要。在目标3中，我们将努力增加代表性和 培训NU-CCNIC生物医学研究队伍中代表性不足的少数民族。在目标4中，我们将 与癌症研究倡导者合作，确保患者视角在NU- 中核集团。在目标5中，我们将与EAP和癌症研究倡导者合作开展NU-CCNIC评估计划 确保及时完成中心的进度，并合理分配资源。

Administrative and Coordination Core: PROJECT SUMMARY The proposed Northwestern University Center for Chromatin NanoImaging in Cancer (NU-CCNIC) will bring together leading cancer research biologists from the Robert H. Lurie Comprehensive Cancer Center in the Feinberg School of Medicine and world-renowned imaging and molecular modeling specialists from the McCormick School of Engineering with the goal of facilitating innovation and application of cutting-edge imaging techniques to help solve some of the most pressing problems in cancer biology research. The Administrative and Coordination Core (ACC) will be led by PI Vadim Backman. The day-to-day administration of the NU-CCNIC will be managed by the Center Administrator, who will be responsible for maintaining all records relative to this award and ensuring communication, synergy, and resource sharing across the NU-CCNIC. Additionally, Center administration will be supported by a Program Manager, who, in collaboration with the Center Administrator, will be responsible for the development of the NU-CCNIC website, scheduling meetings and events, facilitating the sharing of resources, determine whether there will be pre-publication data sharing across the NU-CCNIC, and aid in conversations about data quality control, cross validation, and reproducibility. An External Advisory Panel (EAP) will be formed, bringing together investigators with expertise in fields related to cancer stem cell plasticity and chromatin nanoimaging. The EAP is envisioned as a group of highly active members engaged to advise the NU-CCNIC leadership on scientific direction and review progress evaluation, research strategies and implementation, leadership and dissemination, all in the effort to maximize the impact of the NU-CCNIC. The NU-CCNIC will enhance the translational value and potential impact of its research by engaging a Cancer Research Advocate, who will be a member of the EAP and will be invited to attend NU-CCNIC workshops and site visits. The ACC will support weekly, bi-weekly, monthly, and quarterly research meetings to foster communication, collaboration and integration of the NU-CCNIC and will further support communication and wide- reaching knowledge dissemination through bi-annual workshops with outside speakers. In Aim 1, the Administrative Core will promote and ensure clear and effective communication across the Technology Development (TECH) and Research Test-Bed (RTB) Units. In Aim 2, we will plan and establish regular Center meetings and research workshops to foster communications within the NU-CCNIC and to the broader community that are critical to our research mission and dissemination. In Aim 3, we will work to increase representation and training of underrepresented minorities in the biomedical research workforce of the NU-CCNIC. In Aim 4, we will partner with the cancer research advocate to ensure the critical importance of the patient perspective in the NU- CCNIC. In Aim 5, we will work with the EAP and Cancer Research Advocate on NU-CCNIC evaluation programs to ensure Center progress is accomplished on a timely basis and that resources are allocated judiciously.