Physical Genomics and Engineering Training Program

物理基因组学与工程培训计划

• 批准号: 10633291
• 负责人: Vadim Backman
• 金额: $ 42.44万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10633291
• 关键词: Engineering; Genomics; Training Programs

PROJECT SUMMARY/ABSTRACT The mission of the “Physical Genomics Predoctoral Training Program” (PGTP) is to train the next generation of transdisciplinary scientists that will bridge molecular biology, bioengineering, physics, optics, chemistry, and medicine. Through collaboration of program faculty in the McCormick School of Engineering and Applied Sciences, the Feinberg School of Medicine and the Weinberg College of Arts and Sciences, the PGTP aims to enable trainees to acquire and apply a broad skillset that addresses the physical manipulation of living systems in the pursuit of new strategies for the treatment of disease. Physical genomics is a new field that involves understanding the structure, function, and fundamental principles of chromatin, an intricately folded group of macromolecules including DNA, RNA, and proteins that houses genetic information within cells and determines which genes get suppressed or expressed. With this understanding, researchers can reversibly regulate, control, and even reprogram global patterns of gene expression without altering the genes themselves. This has wide implications in the treatment of diseases such as cancer and Alzheimer’s and other potential applications such as improving crop yields and mitigating the impact of climate change on plants and coral reefs. The PGTP will deploy a range of strategies to help trainees integrate practical, hands-on experience with the knowledge base required to advance research in physical genomics. Through an evidence-based approach to training, trainees will participate in experiential learning and seminars focused on reprogramming chromatin to treat disease and engineer living systems to overcome environmental challenges using breakthrough optical imaging, computational genomics, and molecular biology. The trainees will be mentored by faculty with an outstanding record of productivity and mentorship. Program mentors will provide ongoing review, evaluation, and mentoring of trainees with the goal of creating a resilient, diverse cadre of scientific professionals. The ability to regulate the physical structure of chromatin represents a new frontier in biological discovery and has the potential to be one of the major drivers of 21st-century biotechnology. The PGTP aims to position its trainees as the next generation of interdisciplinary biomedical leaders able to explore this frontier through an exceptional training experience in physical genomics.

项目总结/摘要 “物理基因组学博士前培训计划”（PGTP）的使命是培养下一代 跨学科的科学家，将桥梁分子生物学，生物工程，物理，光学，化学， 药通过工程和应用麦考密克学院的项目教师的合作， 科学，医学范伯格学院和艺术与科学的温伯格学院，PGTP的目标是 使学员能够获得和应用广泛的技能，解决生命系统的物理操作 来寻求治疗疾病的新策略。 物理基因组学是一个新的领域，涉及了解结构，功能和基本原则， 染色质是一组复杂折叠的大分子，包括DNA、RNA和蛋白质， 细胞内的遗传信息，并决定哪些基因被抑制或表达。与此 了解，研究人员可以可逆地调节，控制，甚至重新编程基因的全局模式， 而不改变基因本身。这在治疗疾病方面具有广泛的意义， 作为癌症和阿尔茨海默氏症以及其他潜在应用，例如提高作物产量和减轻疾病 气候变化对植物和珊瑚礁的影响。 PGTP将部署一系列战略，以帮助学员将实践，实践经验与 推进物理基因组学研究所需的知识基础。通过循证方法， 培训，学员将参加体验式学习和研讨会，重点是重编程染色质， 利用突破性的光学技术治疗疾病和设计生命系统，以克服环境挑战 成像、计算基因组学和分子生物学。学员将由教师指导， 出色的生产力和指导记录。项目导师将提供持续的审查、评估和 对受训人员进行指导，目标是培养一支有活力、多样化的科学专业人员队伍。 调节染色质物理结构的能力代表了生物学发现的新前沿， 有可能成为21世纪生物技术的主要驱动力之一。PGTP旨在定位其 学员作为下一代跨学科生物医学领导者，能够通过一个 在物理基因组学方面的特殊训练经验

项目成果

The impact of underrepresented minority or marginalized identity status on training outcomes of MD-PhD students.

• DOI: 10.1186/s12909-023-04399-7
• 发表时间: 2023-06-08
• 期刊: BMC MEDICAL EDUCATION
• 影响因子: 3.6
• 作者: Acosta, Manuel A. Torres A.;Chandra, Sidhanth;Li, Sophia;Yoon, Esther;Selgrade, Daniel;Quinn, Jeanne;Ardehali, Hossein
• 通讯作者: Ardehali, Hossein