MIND-the-SKIN Project: Multi-functional Innovative Digital Toolkit for the Skin Diseases in LMICs and Beyond

MIND-the-SKIN 项目：针对中低收入国家及其他地区皮肤病的多功能创新数字工具包

• 批准号: 10880476
• 负责人: Rie Yotsu
• 金额: $ 27.1万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-25 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10880476
• 关键词: Address; Affect; Africa; Africa South of the Sahara; African; Algorithms; Area; Artificial Intelligence; Buruli Ulcer; Caring; Case Management; Cellular Phone; Child; Clinical; Clinical Skills; Clinical effectiveness; Collaborations; Collection; Communities; Country; Darkness; Data; Data Collection; Decision Support Systems; Deformity; Dermatologic; Dermatologist; Dermatology; Detection; Development; Diagnosis; Diagnostic; Disease Outcome; Early Diagnosis; Early treatment; Economics; Education; Epidemiologic Monitoring; Equipment; Family; Filarial Elephantiases; Future; Goals; Health; Health Personnel; Healthcare; Image; Impact evaluation; Individual; Infectious Skin Diseases; Intervention; Interview; Ivory Coast; Japan; Left; Leprosy; Lesion; Measures; Medical; Methodology; Outcome; Patients; Performance; Phase; Photography; Prevalence; Process; Psyche structure; Recording of previous events; Records; Remote Consultation; Research; Research Personnel; Rural; Series; Services; Site; Skin; Skin Manifestations; Specialist; Standardization; Surveys; System; Tablets; Technology; Telemedicine; Training; Treatment outcome; Tropical Medicine; Underserved Population; Universities; Validation; Visual; Work; World Health Organization; Yaws; clinical decision support; data sharing; design; digital; digital health; disability; disorder control; effectiveness study; experience; follow-up; health training; improved; individual patient; innovation; intelligent diagnosis; low and middle-income countries; mHealth; meetings; member; neglected tropical diseases; novel; physically handicapped; pilot trial; portability; prototype; sharing platform; skills; skin color; skin disorder; skin lesion; social; support tools; teledermatology; tool; two-arm study; usability; wound; wound care; wound healing; wound treatment

MIND-the-SKIN Project: Multi-functional Innovative Digital Toolkit for the Skin Diseases in LMICs and Beyond The prevalence of skin diseases is extremely high in sub-Saharan Africa, particularly in children. If left untreated, some have debilitating lifelong physical disabilities and deformities, as well as social and mental effects. Among them are skin infections which are listed as members of the Neglected Tropical Diseases (NTDs) by the World Health Organization and targeted for disease control globally. Many of the NTDs, including leprosy, Buruli ulcers, yaws, and lymphatic filariasis, are co-endemic in West Africa. Early detection and treatment is currently the most effective measures for their disease control. However, this is hampered by a paucity of skilled healthcare workers in the remote areas of the LMICs where they prevail. On the other hand, diagnosis of these conditions can be done with patient history and simple skin examination, without undergoing invasive examinations requiring special skills and equipment. This is very well suited to field settings in LMICs. With a targeted training, technology-assisted decision-support system and a telemedicine network, local healthcare workers could be leveraged to enhance the diagnosis and management of the skin conditions. This project proposes to do so through development and validation of an mHealth tool for skin diseases in LMICs: the ‘eSkinHealth’ application. It is a portable smartphone or tablet application that could provide: a) direct diagnostic and management assistance to healthcare workers in remote setting, and through teledermatology, b) storage of longitudinal patients records for improved follow-up, and c) organization of clinical and image data of the skin. There is a general lack of good clinical photos of skin diseases on dark skin, and collection of photos made through this project could be further used for development of photo guides for wide use and future studies on dermatology of skin of color. The purpose of the proposed research is to complete development and optimization of eSkinHealth and carry out its effectiveness studies on the field. The R21 phase of the work will assess the feasibility, usability, and acceptability of the prototype, validation of a novel built-in wound scoring system, and standardization and optimization of dermatologic photography on dark skin. The R33 phase will evaluate the performance of the app on outcomes of surveillance and management of NTDs and further optimization of photo analysis of skin lesions on dark skin using the image optimization technology. The research will be carried out in a western-African country of Côte d’Ivoire. It will build on our previous work in surveillance of NTDs in rural Côte d’Ivoire and trainings to local healthcare workers, as well as our expertise in mHealth. It will leverage our multi-year collaboration with investigators from Côte d’Ivoire, application developers in Japan, and tropical medicine expertise from Tulane University. If successful, eSkinHealth will be instrumental in overcoming the current gaps and weaknesses in dermatological services in LMICs providing a breakthrough to management of skin diseases in this underserved populations, as well as contributing to the dermatology of skin of color worldwide, envisioning Skin Health for All.

MIND-the-SKIN项目：针对中低收入国家和地区皮肤病的多功能创新数字工具包 超出 在撒哈拉以南非洲，皮肤病的流行率极高，特别是在儿童中。如果放任 未经治疗，有些人会终身身体残疾和畸形，以及社会和精神残疾。 方面的影响.其中包括被列为被忽视的热带病成员的皮肤感染 （NTDs），并针对全球疾病控制。许多NTD， 包括麻风病、布鲁里溃疡、雅司病和淋巴丝虫病，在西非共同流行。早期检测 治疗是目前控制该病最有效的措施。然而，这受到以下因素的阻碍： 在低收入国家的偏远地区，缺乏熟练的保健工作者。另一方面，在一项研究中， 这些疾病的诊断可以通过患者病史和简单的皮肤检查来完成，而不需要进行 需要特殊技能和设备的侵入性检查。这非常适合中低收入国家的实地设置。 通过有针对性的培训、技术辅助决策支持系统和远程医疗网络， 可以利用保健工作者来加强皮肤状况的诊断和管理。这 该项目建议通过开发和验证一个用于治疗中低收入国家皮肤病的移动健康工具来实现这一目标： “eSkinHealth”应用程序。它是一个便携式智能手机或平板电脑应用程序，可以提供：a）直接 通过远程皮肤病学， B）纵向患者记录的存储，以改善随访，以及c）临床和图像数据的组织 的皮肤。目前普遍缺乏好的皮肤病的临床照片对深色皮肤，并收集 通过该项目拍摄的照片可进一步用于制作照片指南，供广泛使用， 彩色皮肤的皮肤病学研究前景。研究的目的是完成 开发和优化eSkinHealth，并在该领域开展有效性研究。R21 该阶段的工作将评估可行性，可用性，和原型的可接受性，验证一个新的 内置的伤口评分系统，以及深色皮肤的皮肤病学摄影的标准化和优化。 R33阶段将评估应用程序在以下监测和管理结果方面的性能： NTD和使用图像优化进一步优化深色皮肤上皮肤病变的照片分析 技术.这项研究将在西非国家科特迪瓦进行。它将建立在我们的 以前在科特迪瓦农村监测NTD的工作和对当地卫生保健工作者的培训，以及 我们在移动健康方面的专业知识。它将利用我们与科特迪瓦调查人员的多年合作， 日本的应用程序开发人员和杜兰大学的热带医学专家。如果成功， eSkinHealth将有助于克服目前皮肤科服务的差距和弱点， LMIC为这一服务不足人群的皮肤病管理提供了突破， 为全世界有色人种的皮肤病学做出贡献，为所有人的皮肤健康做出贡献。