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Quantitative assessment of early structural and functional changes in aging skeletal muscle

衰老骨骼肌早期结构和功能变化的定量评估

基本信息

批准号：
10887136
负责人：
Valentina Mazzoli
金额：
$ 24.9万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-06-01 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10887136
关键词：
Address Affect Aging Architecture Atrophic Biological Markers Biology Biomechanics Biopsy Caring Cause of Death Cell Size Clinical Collagen Communities Deposition Detection Development Diffusion Magnetic Resonance Imaging Disease Early Diagnosis Early identification Elderly Evaluation Exercise Fatty acid glycerol esters Fiber Fibrosis Geometry Goals Health Health Care Costs Histologic Human Image Imaging Device Individual Infiltration Inflammation Intervention Length Longitudinal Studies Lower Extremity Magnetic Resonance Imaging Maps Measurement Measures Medical Methods Monitor Morbidity - disease rate Muscle Muscle Cells Muscle Fibers Muscle function Muscular Atrophy Musculoskeletal Myopathy Outcome Pathogenesis Pathologic Patients Physical Function Physical Performance Physical assessment Physiologic pulse Population Protocols documentation Radiology Specialty Reproducibility Research Research Personnel Risk Sensitivity and Specificity Severity of illness Skeletal Muscle Syndrome Techniques Tendon structure Tissues Training United States Work age related age stratification aged aging population biomechanical model biophysical model clinical imaging clinical research site cohort cost disability falls follow-up frailty functional improvement functional outcomes functional status high risk imaging approach imaging modality innovation insight magnetic resonance imaging biomarker mortality multidisciplinary muscle form muscle strength non-invasive imaging novel novel imaging technique novel therapeutics oscillating gradient spin echo preservation sarcopenia tool vastus lateralis

项目摘要

Project Summary/Abstract Sarcopenia is a leading cause of death and disability for the aging population and creates a societal burden resulting in $18 billion in annual costs in the United States alone. While new treatments have shown promise to improve functional outcomes, they have been hampered by the lack of non-invasive biomarkers sensitive to the early stages of the disease. In particular, non-invasive assessment of muscle atrophy is a long-recognized but unmet need in the sarcopenia community, and we propose to use magnetic resonance imaging (MRI) to address this need. This project develops a clinically feasible toolset to noninvasively image early atrophic changes in skeletal muscle using Magnetic Resonance Imaging (MRI). Our specific aims are (1) to develop new MRI techniques that utilize a novel pulse sequence to quantify muscle cell size and changes thereof due to atrophy; (2) to validate MR atrophy imaging with histological evaluation of muscle biopsies from young and older subjects, and correlate with muscle strength; and (3) to apply MRI atrophy methods to study longitudinal changes in sarcopenic patients and in pre-frail subjects, which are at high risk of developing sarcopenia. The innovation of this work lies in the development of a novel imaging technique to quantify atrophy in muscle tissue non-invasively. The outcome of this proposal is a validated and quantitative MRI tool to image muscle quality, and its relationship to patient strength and functional status. The significance of this work is a robust clinical MRI protocol to image early degenerative changes associated to sarcopenia that is transferrable to any clinical site. The reproducible and robust tool will allow the sarcopenia imaging community to identify subject at risk, and implement targeted and timely interventions that can stop or slow the progression of sarcopenia.

项目总结/文摘