PROCEED + DETECT Year 9 supplement patient care costs

摘要/摘要 慢性胰腺炎、糖尿病和胰腺癌研究联合会 (CPDPC)是由NIH赞助的几个研讨会的结果，这些研讨会的重点是 明确改善胰腺疾病患者护理的重要研究目标。这个 CPDPC的目标一直是研究临床上重要的相互关系 胰腺炎、糖尿病和胰腺癌，重点是更好地了解机制， 病理生理学和自然病史，关于提高早期诊断，发现特定的 生物标志物，并最终成为勘探和后续更大规模研究的平台 临床试验。和平与发展委员会通过建立若干 未来的患者队列，通过形成几个工作小组来协调和计划 组。这些工作组(WG)包括CP成人工作组、CP儿科工作组、DM PDAC WG和3C型DM WG。由CP成人工作组组织的继续队列将 最终包括1600名成人受试者，重点是急性、急性复发、 和慢性胰腺炎。由CP儿科工作组组织的INSPIRRE 2队列将是 包括860名患有急性复发和慢性胰腺炎的儿童。检测到的队列， 由3C型糖尿病工作组组织，正在招募典型的2型糖尿病患者作为 以及患有胰腺癌或慢性胰腺炎的糖尿病患者，以确定 这些类型的糖尿病之间的机制差异，并利用这些信息 生物标志物和治疗效益。每个队列将代表深度的一个大样本 表型和特化的受试者，带有全面的注释的生物样品(生物学 样本(放射学)收集，随着时间的推移而被跟踪。这些队列，当完全 招聘和跟踪，提供了独特和强大的资源，以解决许多 尚未回答的临床问题，并解决CPDPC宪章的目标。CPDPC是 组织以允许许多辅助研究与主要队列并行进行 这些辅助研究现已超过50项。这些辅助研究 帮助指导国家发改委的工作，并建立了一套方法和协议来 指导该联盟，并为未来的临床提供明确的方法和定义 对这些疾病的研究。CPDPC的结构提供了一个无与伦比的机会 用于内部和外部合作，以促进临床研究和开发更有效的 复杂胰腺疾病的预测、预防和治疗。

Summary/Abstract The Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC) was formed as a consequence of several NIH-sponsored workshops focused on defining important research goals for improving care of patients with pancreatic diseases. The goals of the CPDPC have been to investigate the clinically important inter-relationships between pancreatitis, diabetes, and pancreatic cancer, focused on better understanding mechanisms, pathophysiology, and natural history, on improving early diagnosis, discovering specific biomarkers, and ultimately serving as a platform for exploratory and subsequent larger-scale clinical trials. The CPDPC undertook these efforts through the establishment of several prospective patient cohorts, coordinated and planned through the formation of several working groups. These working groups (WGs) include the CP Adult WG, CP Pediatric WG, DM PDAC WG, and the Type3C DM WG. The PROCEED cohort, organized by the CP Adult WG, will ultimately include 1600 adult subjects, and is focused on patients with acute, acute relapsing, and chronic pancreatitis. The INSPIRRE 2 cohort, organized by the CP Pediatric WG, will be comprised of 860 children with acute relapsing and chronic pancreatitis. The DETECT cohort, organized by the Type3C DM WG, is recruiting subjects with typical Type 2 diabetes mellitus as well as patients with diabetes due to pancreatic cancer or chronic pancreatitis, to determine mechanistic differences between these types of diabetes and leverage that information for biomarker and therapeutic benefit. Each cohort will represent a large sample of deeply phenotyped and characterized subjects, with comprehensive annotated biospecimen (biologic samples, radiographic) collection, who are being followed over time. These cohorts, when fully recruited and followed-up, provide a unique and powerful resource to address many unanswered clinical questions and to address the goals of the CPDPC charter. The CPDPC is organized to allow numerous ancillary studies to proceed in parallel to the main cohort recruitment, and these ancillary studies now number more than 50. These ancillary studies have helped inform the work of the CPDPC, and established a set of methods and protocols to guide the consortium, as well as provide defined methods and definitions for future clinical research in these diseases. The structure of the CPDPC provides an unparalleled opportunity for internal and external collaboration to foster clinical studies and develop more effective prediction, prevention, and treatment of complex pancreatic diseases.