Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry
多供应商多站点新型加速 MRI 松弛测量
基本信息
- 批准号:10861563
- 负责人:
- 金额:$ 30.59万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-15 至 2025-04-30
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAcuteAffectAgeAreaBody mass indexBrainCaringCartilageChronicClinicalCoupledDataDegenerative polyarthritisDiseaseEconomic BurdenEvaluationFunctional Magnetic Resonance ImagingFutureGoalsHealth Care CostsHigh PrevalenceImageImaging technologyImmune systemImpairmentInjuryInvestigationJointsKneeKnee InjuriesKnee OsteoarthritisKnee jointMagnetic Resonance ImagingMapsMethodsModelingMorbidity - disease rateMusculoskeletal DiseasesMusculoskeletal PainNational Institute of Arthritis, and Musculoskeletal, and Skin DiseasesNatureNervous SystemNeuropathyNociceptionNociceptorsOnset of illnessOperative Surgical ProceduresOrthopedicsOutcomeOutcome StudyPainPain ResearchPain managementParentsPathogenicityPatient Outcomes AssessmentsPatientsPatternPersonsPlayPopulationPrevalenceProcessQuality of lifeQuestionnairesReplacement ArthroplastyReportingResourcesRoleSiteStructureSymptomsSystemTechniquesTimeTissuesTraumatic ArthropathyVendorVisitWorkanterior cruciate ligament injuryanterior cruciate ligament reconstructionanterior cruciate ligament rupturearthropathiesbiomarker identificationbrain magnetic resonance imagingcohortcostdisabilityexperiencehealth economicshigh riskimaging biomarkerimaging studyimprovedinfancyinnovationinsightinterestjoint injuryknee painmultimodalityneuralneuroimagingneuromechanismnew therapeutic targetnovelnovel imaging techniquenovel therapeutic interventionopioid epidemicosteoarthritis painpain reliefpainful neuropathypatient populationpersistent symptompredictive markerprescription opioidradiomicssexsocioeconomics
项目摘要
PROJECT SUMMARY/ABSTRACT
This urgent competitive revision responds to NIAMS Notice of Special Interest (NOSI) NOT-AR-23-015. The
parent study (NIAMS R01 AR077452) aims to develop novel quantitative MRI techniques (accelerated MR T1ρ
and T2 mapping) to evaluate cartilage compositional changes and early degeneration in patients after anterior
cruciate ligament reconstruction (ACLR), a population at high risk of developing post-traumatic osteoarthritis
(PTOA). In this study, we aim to explore the mechanisms in musculoskeletal (MSK) pain and identify novel
imaging (knee and brain) markers for pain after ACL injury and surgery, and at early PTOA. The proposed
study will significantly expand the scope of the parent study from only focusing on structural changes (‘disease’)
to one evaluating patient symptoms (‘illness’, in particular pain) in OA. With a novel multi-modal approach that
includes advanced knee and brain MRI, our group will, for the first time, investigate central neural system (CNS)
alterations in pain post orthopaedic injury/surgery, and in early PTOA. The study outcomes will provide critical
preliminary data to formulate specific hypotheses for MSK pain, and will develop novel imaging techniques that
can be utilized for future large-scale studies of pain mechanisms following orthopaedic injury/surgery and in
OA/PTOA, an under-investigated area with pressing clinical needs. As such, the proposed study is aligned with
the NOSI Goal A: Generate supporting evidence towards a future innovative study or new scientific direction in
pain research in musculoskeletal diseases, in the areas of interest of novel pain imaging technologies.
OA affects 30+ million people in the US and 300+ million people worldwide. It presents tremendous health and
socioeconomic burdens with health care costs and work loss. Pain is the major factor that significantly impairs
quality of life, leads to disability, and prompts patients for clinical visits and eventually total joint arthroplasty for
OA. Opioid prescriptions for severe OA/PTOA pain and pain after orthopaedic injury are common, which
constitutes a significant contribution to the national opioid crisis due to its high prevalence. A better
understanding of the mechanisms of post-injury/surgery and OA/PTOA pains and identifying biomarkers that are
associated with or predict MSK pain, the gap the proposed study aims to fill, will provide useful guidance on
developing novel therapeutic targets for pain relief in OA and other MSK disorders. The proposed study presents
a significant and timely expansion of the parent study. It will leverage the resources from the parent study and
provide a unique opportunity to investigate relationship between joint structural damages, CNS alternations, and
pain in a novel early OA model (PTOA, after orthopaedic injury and surgery). The study outcomes will provide
valuable insights to MSK pain mechanisms, help identify new treatment targets for pain relief in this
huge patient population, and eventually help with providing scientific solutions to battle against the ever-
increasing opioid epidemic in the US.
项目总结/摘要
本紧急竞争性修订是对NIAMS特别关注通知(NOSI)NOT-AR-23-015的回应。的
母研究(NIAMS R 01 AR 077452)旨在开发新型定量MRI技术(加速MR T1ρ
和T2映射),以评估患者在前路手术后的软骨成分变化和早期退变。
交叉韧带重建(ACLR),创伤后骨关节炎高危人群
(PTOA)。在这项研究中,我们的目的是探索肌肉骨骼(MSK)疼痛的机制,并确定新的
ACL损伤和手术后以及PTOA早期的疼痛成像(膝关节和脑)标记物。拟议
研究将显著扩大母研究的范围,从仅关注结构变化(“疾病”)
评估OA患者症状(“疾病”,特别是疼痛)的方法。采用新颖的多模式方法,
包括先进的膝关节和脑MRI,我们的团队将首次研究中枢神经系统(CNS)
骨科损伤/手术后疼痛和PTOA早期的变化。研究结果将提供关键的
初步数据,制定具体的假设MSK疼痛,并将开发新的成像技术,
可用于未来骨科损伤/手术后疼痛机制的大规模研究,
OA/PTOA,一个研究不足的领域,具有迫切的临床需求。因此,拟议的研究符合
NOSI目标A:为未来的创新研究或新的科学方向提供支持证据,
在肌肉骨骼疾病的疼痛研究,在新的疼痛成像技术感兴趣的领域。
OA影响美国3000多万人和全球3亿多人。它代表着巨大的健康,
社会经济负担与医疗保健成本和工作损失。疼痛是显著损害
生活质量,导致残疾,并促使患者进行临床访视,最终进行全关节置换术,
OA。阿片类药物处方用于严重OA/PTOA疼痛和骨科损伤后疼痛很常见,
由于其高流行率,对全国类阿片危机作出了重大贡献。更好的
了解损伤后/手术和OA/PTOA疼痛的机制,并确定
与MSK疼痛相关或预测MSK疼痛,所提出的研究旨在填补的差距,将提供有用的指导,
开发用于缓解OA和其他MSK疾病疼痛的新治疗靶点。拟议的研究提出
对母研究进行了重大而及时的扩展。它将利用母研究的资源,
提供了一个独特的机会,调查关节结构损伤,中枢神经系统的变化,
一种新型早期OA模型(PTOA,骨科损伤和手术后)中的疼痛。研究结果将提供
有价值的见解MSK疼痛机制,帮助确定新的治疗目标,缓解疼痛,
庞大的患者群体,并最终帮助提供科学的解决方案,以对抗不断-
阿片类药物在美国日益流行。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Efficient phase-cycling strategy for high-resolution 3D gradient-echo quantitative parameter mapping.
- DOI:10.1002/nbm.4700
- 发表时间:2022-07
- 期刊:
- 影响因子:2.9
- 作者:
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Xiaojuan Li其他文献
Xiaojuan Li的其他文献
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{{ truncateString('Xiaojuan Li', 18)}}的其他基金
Optimizing care for older adults in the new treatment era for type 2 diabetes and heart failure: Strengthening causal inference through novel approaches and evidence triangulation
在 2 型糖尿病和心力衰竭的新治疗时代优化老年人护理:通过新方法和证据三角测量加强因果推理
- 批准号:
10449576 - 财政年份:2022
- 资助金额:
$ 30.59万 - 项目类别:
Optimizing care for older adults in the new treatment era for type 2 diabetes and heart failure: Strengthening causal inference through novel approaches and evidence triangulation
在 2 型糖尿病和心力衰竭的新治疗时代优化老年人护理:通过新方法和证据三角测量加强因果推理
- 批准号:
10673040 - 财政年份:2022
- 资助金额:
$ 30.59万 - 项目类别:
Novel causal inference methods to inform clinical decision on when to discontinue symptomatic treatment for patients with dementia
新的因果推断方法可为痴呆患者何时停止对症治疗提供临床决策
- 批准号:
10322425 - 财政年份:2021
- 资助金额:
$ 30.59万 - 项目类别:
Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry
多供应商多站点新型加速 MRI 松弛测量
- 批准号:
10396509 - 财政年份:2020
- 资助金额:
$ 30.59万 - 项目类别:
Enhanced MR for morphological characterization of ligaments, tendons and bone
增强 MR 用于韧带、肌腱和骨骼的形态表征
- 批准号:
10709528 - 财政年份:2020
- 资助金额:
$ 30.59万 - 项目类别:
Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry
多供应商多站点新型加速 MRI 松弛测量
- 批准号:
10677551 - 财政年份:2020
- 资助金额:
$ 30.59万 - 项目类别:
Enhanced MR for morphological characterization of ligaments, tendons and bone
增强 MR 用于韧带、肌腱和骨骼的形态表征
- 批准号:
10246251 - 财政年份:2020
- 资助金额:
$ 30.59万 - 项目类别:
Imaging post-traumatic osteoarthritis 10-years after ACL reconstruction: a multicenter cohort study with quantitative MRI
ACL 重建 10 年后创伤后骨关节炎的影像学:定量 MRI 的多中心队列研究
- 批准号:
10878519 - 财政年份:2019
- 资助金额:
$ 30.59万 - 项目类别:
Imaging post-traumatic osteoarthritis 10-years after ACL reconstruction: a multicenter cohort study with quantitative MRI
ACL 重建 10 年后创伤后骨关节炎的影像学:定量 MRI 的多中心队列研究
- 批准号:
10441228 - 财政年份:2019
- 资助金额:
$ 30.59万 - 项目类别:
Imaging post-traumatic osteoarthritis 10-years after ACL reconstruction: a multicenter cohort study with quantitative MRI
ACL 重建 10 年后创伤后骨关节炎的影像学:定量 MRI 的多中心队列研究
- 批准号:
9978715 - 财政年份:2019
- 资助金额:
$ 30.59万 - 项目类别:
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