Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry

多供应商多站点新型加速 MRI 松弛测量

基本信息

  • 批准号:
    10861563
  • 负责人:
  • 金额:
    $ 30.59万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-09-15 至 2025-04-30
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY/ABSTRACT This urgent competitive revision responds to NIAMS Notice of Special Interest (NOSI) NOT-AR-23-015. The parent study (NIAMS R01 AR077452) aims to develop novel quantitative MRI techniques (accelerated MR T1ρ and T2 mapping) to evaluate cartilage compositional changes and early degeneration in patients after anterior cruciate ligament reconstruction (ACLR), a population at high risk of developing post-traumatic osteoarthritis (PTOA). In this study, we aim to explore the mechanisms in musculoskeletal (MSK) pain and identify novel imaging (knee and brain) markers for pain after ACL injury and surgery, and at early PTOA. The proposed study will significantly expand the scope of the parent study from only focusing on structural changes (‘disease’) to one evaluating patient symptoms (‘illness’, in particular pain) in OA. With a novel multi-modal approach that includes advanced knee and brain MRI, our group will, for the first time, investigate central neural system (CNS) alterations in pain post orthopaedic injury/surgery, and in early PTOA. The study outcomes will provide critical preliminary data to formulate specific hypotheses for MSK pain, and will develop novel imaging techniques that can be utilized for future large-scale studies of pain mechanisms following orthopaedic injury/surgery and in OA/PTOA, an under-investigated area with pressing clinical needs. As such, the proposed study is aligned with the NOSI Goal A: Generate supporting evidence towards a future innovative study or new scientific direction in pain research in musculoskeletal diseases, in the areas of interest of novel pain imaging technologies. OA affects 30+ million people in the US and 300+ million people worldwide. It presents tremendous health and socioeconomic burdens with health care costs and work loss. Pain is the major factor that significantly impairs quality of life, leads to disability, and prompts patients for clinical visits and eventually total joint arthroplasty for OA. Opioid prescriptions for severe OA/PTOA pain and pain after orthopaedic injury are common, which constitutes a significant contribution to the national opioid crisis due to its high prevalence. A better understanding of the mechanisms of post-injury/surgery and OA/PTOA pains and identifying biomarkers that are associated with or predict MSK pain, the gap the proposed study aims to fill, will provide useful guidance on developing novel therapeutic targets for pain relief in OA and other MSK disorders. The proposed study presents a significant and timely expansion of the parent study. It will leverage the resources from the parent study and provide a unique opportunity to investigate relationship between joint structural damages, CNS alternations, and pain in a novel early OA model (PTOA, after orthopaedic injury and surgery). The study outcomes will provide valuable insights to MSK pain mechanisms, help identify new treatment targets for pain relief in this huge patient population, and eventually help with providing scientific solutions to battle against the ever- increasing opioid epidemic in the US.
项目概要/摘要 此紧急竞争性修订是对 NIAMS 特别利益通知 (NOSI) NOT-AR-23-015 的回应。这 母研究 (NIAMS R01 AR077452) 旨在开发新型定量 MRI 技术(加速 MR T1ρ 和 T2 映射)来评估前路术后患者的软骨成分变化和早期退化 十字韧带重建(ACLR),是患创伤后骨关节炎的高危人群 (PTOA)。在本研究中,我们旨在探索肌肉骨骼 (MSK) 疼痛的机制并确定新的治疗方法 ACL 损伤和手术后以及早期 PTOA 疼痛的成像(膝盖和大脑)标记。拟议的 研究将显着扩大母研究的范围,不再只关注结构变化(“疾病”) 一位评估 OA 患者症状(“疾病”,特别是疼痛)的人。通过一种新颖的多模式方法 包括先进的膝盖和大脑 MRI,我们的小组将首次研究中枢神经系统 (CNS) 骨科损伤/手术后以及早期 PTOA 中疼痛的变化。研究结果将提供关键 初步数据来制定 MSK 疼痛的具体假设,并将开发新颖的成像技术 可用于未来骨科损伤/手术后疼痛机制的大规模研究以及 OA/PTOA,一个研究不足且临床需求紧迫的领域。因此,拟议的研究符合 NOSI 目标 A:为未来的创新研究或新的科学方向提供支持证据 在新型疼痛成像技术感兴趣的领域进行肌肉骨骼疾病的疼痛研究。 OA 影响着美国 30 多万人和全球 3 亿多人。它呈现出巨大的健康和 医疗保健费用和工作损失等社会经济负担。疼痛是显着损害的主要因素 生活质量,导致残疾,并促使患者进行临床就诊并最终进行全关节置换术 办公自动化。用于治疗严重 OA/PTOA 疼痛和骨科损伤后疼痛的阿片类药物处方很常见, 由于其流行率很高,对国家阿片类药物危机造成了重大影响。更好的 了解受伤/手术后和 OA/PTOA 疼痛的机制并识别生物标志物 与 MSK 疼痛相关或预测 MSK 疼痛是拟议研究旨在填补的空白,将为以下方面提供有用的指导: 开发缓解 OA 和其他 MSK 疾病疼痛的新治疗靶点。拟议的研究提出 家长研究的重大和及时的扩展。它将利用家长研究的资源 提供了一个独特的机会来研究关节结构损伤、中枢神经系统改变和 新型早期 OA 模型(PTOA,骨科损伤和手术后)中的疼痛。研究成果将提供 对 MSK 斯隆疼痛机制的宝贵见解,有助于确定缓解疼痛的新治疗目标 庞大的患者群体,并最终帮助提供科学的解决方案来对抗日益严重的疾病 美国阿片类药物流行日益严重。

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Efficient phase-cycling strategy for high-resolution 3D gradient-echo quantitative parameter mapping.
  • DOI:
    10.1002/nbm.4700
  • 发表时间:
    2022-07
  • 期刊:
  • 影响因子:
    2.9
  • 作者:
  • 通讯作者:
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Xiaojuan Li其他文献

Xiaojuan Li的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Xiaojuan Li', 18)}}的其他基金

Optimizing care for older adults in the new treatment era for type 2 diabetes and heart failure: Strengthening causal inference through novel approaches and evidence triangulation
在 2 型糖尿病和心力衰竭的新治疗时代优化老年人护理:通过新方法和证据三角测量加强因果推理
  • 批准号:
    10449576
  • 财政年份:
    2022
  • 资助金额:
    $ 30.59万
  • 项目类别:
Optimizing care for older adults in the new treatment era for type 2 diabetes and heart failure: Strengthening causal inference through novel approaches and evidence triangulation
在 2 型糖尿病和心力衰竭的新治疗时代优化老年人护理:通过新方法和证据三角测量加强因果推理
  • 批准号:
    10673040
  • 财政年份:
    2022
  • 资助金额:
    $ 30.59万
  • 项目类别:
Novel causal inference methods to inform clinical decision on when to discontinue symptomatic treatment for patients with dementia
新的因果推断方法可为痴呆患者何时停止对症治疗提供临床决策
  • 批准号:
    10322425
  • 财政年份:
    2021
  • 资助金额:
    $ 30.59万
  • 项目类别:
Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry
多供应商多站点新型加速 MRI 松弛测量
  • 批准号:
    10396509
  • 财政年份:
    2020
  • 资助金额:
    $ 30.59万
  • 项目类别:
Enhanced MR for morphological characterization of ligaments, tendons and bone
增强 MR 用于韧带、肌腱和骨骼的形态表征
  • 批准号:
    10709528
  • 财政年份:
    2020
  • 资助金额:
    $ 30.59万
  • 项目类别:
Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry
多供应商多站点新型加速 MRI 松弛测量
  • 批准号:
    10677551
  • 财政年份:
    2020
  • 资助金额:
    $ 30.59万
  • 项目类别:
Enhanced MR for morphological characterization of ligaments, tendons and bone
增强 MR 用于韧带、肌腱和骨骼的形态表征
  • 批准号:
    10246251
  • 财政年份:
    2020
  • 资助金额:
    $ 30.59万
  • 项目类别:
Imaging post-traumatic osteoarthritis 10-years after ACL reconstruction: a multicenter cohort study with quantitative MRI
ACL 重建 10 年后创伤后骨关节炎的影像学:定量 MRI 的多中心队列研究
  • 批准号:
    10878519
  • 财政年份:
    2019
  • 资助金额:
    $ 30.59万
  • 项目类别:
Imaging post-traumatic osteoarthritis 10-years after ACL reconstruction: a multicenter cohort study with quantitative MRI
ACL 重建 10 年后创伤后骨关节炎的影像学:定量 MRI 的多中心队列研究
  • 批准号:
    10441228
  • 财政年份:
    2019
  • 资助金额:
    $ 30.59万
  • 项目类别:
Imaging post-traumatic osteoarthritis 10-years after ACL reconstruction: a multicenter cohort study with quantitative MRI
ACL 重建 10 年后创伤后骨关节炎的影像学:定量 MRI 的多中心队列研究
  • 批准号:
    9978715
  • 财政年份:
    2019
  • 资助金额:
    $ 30.59万
  • 项目类别:

相似海外基金

Acute senescence: a novel host defence counteracting typhoidal Salmonella
急性衰老:对抗伤寒沙门氏菌的新型宿主防御
  • 批准号:
    MR/X02329X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 30.59万
  • 项目类别:
    Fellowship
Transcriptional assessment of haematopoietic differentiation to risk-stratify acute lymphoblastic leukaemia
造血分化的转录评估对急性淋巴细胞白血病的风险分层
  • 批准号:
    MR/Y009568/1
  • 财政年份:
    2024
  • 资助金额:
    $ 30.59万
  • 项目类别:
    Fellowship
Combining two unique AI platforms for the discovery of novel genetic therapeutic targets & preclinical validation of synthetic biomolecules to treat Acute myeloid leukaemia (AML).
结合两个独特的人工智能平台来发现新的基因治疗靶点
  • 批准号:
    10090332
  • 财政年份:
    2024
  • 资助金额:
    $ 30.59万
  • 项目类别:
    Collaborative R&D
Cellular Neuroinflammation in Acute Brain Injury
急性脑损伤中的细胞神经炎症
  • 批准号:
    MR/X021882/1
  • 财政年份:
    2024
  • 资助金额:
    $ 30.59万
  • 项目类别:
    Research Grant
STTR Phase I: Non-invasive focused ultrasound treatment to modulate the immune system for acute and chronic kidney rejection
STTR 第一期:非侵入性聚焦超声治疗调节免疫系统以治疗急性和慢性肾排斥
  • 批准号:
    2312694
  • 财政年份:
    2024
  • 资助金额:
    $ 30.59万
  • 项目类别:
    Standard Grant
Combining Mechanistic Modelling with Machine Learning for Diagnosis of Acute Respiratory Distress Syndrome
机械建模与机器学习相结合诊断急性呼吸窘迫综合征
  • 批准号:
    EP/Y003527/1
  • 财政年份:
    2024
  • 资助金额:
    $ 30.59万
  • 项目类别:
    Research Grant
FITEAML: Functional Interrogation of Transposable Elements in Acute Myeloid Leukaemia
FITEAML:急性髓系白血病转座元件的功能研究
  • 批准号:
    EP/Y030338/1
  • 财政年份:
    2024
  • 资助金额:
    $ 30.59万
  • 项目类别:
    Research Grant
KAT2A PROTACs targetting the differentiation of blasts and leukemic stem cells for the treatment of Acute Myeloid Leukaemia
KAT2A PROTAC 靶向原始细胞和白血病干细胞的分化,用于治疗急性髓系白血病
  • 批准号:
    MR/X029557/1
  • 财政年份:
    2024
  • 资助金额:
    $ 30.59万
  • 项目类别:
    Research Grant
ロボット支援肝切除術は真に低侵襲なのか?acute phaseに着目して
机器人辅助肝切除术真的是微创吗?
  • 批准号:
    24K19395
  • 财政年份:
    2024
  • 资助金额:
    $ 30.59万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Collaborative Research: Changes and Impact of Right Ventricle Viscoelasticity Under Acute Stress and Chronic Pulmonary Hypertension
合作研究:急性应激和慢性肺动脉高压下右心室粘弹性的变化和影响
  • 批准号:
    2244994
  • 财政年份:
    2023
  • 资助金额:
    $ 30.59万
  • 项目类别:
    Standard Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了