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Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry

多供应商多站点新型加速 MRI 松弛测量

基本信息

批准号：
10861563
负责人：
Xiaojuan Li
金额：
$ 30.59万
依托单位：
CLEVELAND CLINIC LERNER COM-CWRU
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-15 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10861563
关键词：
Acceleration Acute Affect Age Area Body mass index Brain Caring Cartilage Chronic Clinical Coupled Data Degenerative polyarthritis Disease Economic Burden Evaluation Functional Magnetic Resonance Imaging Future Goals Health Care Costs High Prevalence Image Imaging technology Immune system Impairment Injury Investigation Joints Knee Knee Injuries Knee Osteoarthritis Knee joint Magnetic Resonance Imaging Maps Methods Modeling Morbidity - disease rate Musculoskeletal Diseases Musculoskeletal Pain National Institute of Arthritis, and Musculoskeletal, and Skin Diseases Nature Nervous System Neuropathy Nociception Nociceptors Onset of illness Operative Surgical Procedures Orthopedics Outcome Outcome Study Pain Pain Research Pain management Parents Pathogenicity Patient Outcomes Assessments Patients Pattern Persons Play Population Prevalence Process Quality of life Questionnaires Replacement Arthroplasty Reporting Resources Role Site Structure Symptoms System Techniques Time Tissues Traumatic Arthropathy Vendor Visit Work anterior cruciate ligament injury anterior cruciate ligament reconstruction anterior cruciate ligament rupture arthropathies biomarker identification brain magnetic resonance imaging cohort cost disability experience health economics high risk imaging biomarker imaging study improved infancy innovation insight interest joint injury knee pain multimodality neural neuroimaging neuromechanism new therapeutic target novel novel imaging technique novel therapeutic intervention opioid epidemic osteoarthritis pain pain relief painful neuropathy patient population persistent symptom predictive marker prescription opioid radiomics sex socioeconomics

项目摘要

PROJECT SUMMARY/ABSTRACT This urgent competitive revision responds to NIAMS Notice of Special Interest (NOSI) NOT-AR-23-015. The parent study (NIAMS R01 AR077452) aims to develop novel quantitative MRI techniques (accelerated MR T1ρ and T2 mapping) to evaluate cartilage compositional changes and early degeneration in patients after anterior cruciate ligament reconstruction (ACLR), a population at high risk of developing post-traumatic osteoarthritis (PTOA). In this study, we aim to explore the mechanisms in musculoskeletal (MSK) pain and identify novel imaging (knee and brain) markers for pain after ACL injury and surgery, and at early PTOA. The proposed study will significantly expand the scope of the parent study from only focusing on structural changes (‘disease’) to one evaluating patient symptoms (‘illness’, in particular pain) in OA. With a novel multi-modal approach that includes advanced knee and brain MRI, our group will, for the first time, investigate central neural system (CNS) alterations in pain post orthopaedic injury/surgery, and in early PTOA. The study outcomes will provide critical preliminary data to formulate specific hypotheses for MSK pain, and will develop novel imaging techniques that can be utilized for future large-scale studies of pain mechanisms following orthopaedic injury/surgery and in OA/PTOA, an under-investigated area with pressing clinical needs. As such, the proposed study is aligned with the NOSI Goal A: Generate supporting evidence towards a future innovative study or new scientific direction in pain research in musculoskeletal diseases, in the areas of interest of novel pain imaging technologies. OA affects 30+ million people in the US and 300+ million people worldwide. It presents tremendous health and socioeconomic burdens with health care costs and work loss. Pain is the major factor that significantly impairs quality of life, leads to disability, and prompts patients for clinical visits and eventually total joint arthroplasty for OA. Opioid prescriptions for severe OA/PTOA pain and pain after orthopaedic injury are common, which constitutes a significant contribution to the national opioid crisis due to its high prevalence. A better understanding of the mechanisms of post-injury/surgery and OA/PTOA pains and identifying biomarkers that are associated with or predict MSK pain, the gap the proposed study aims to fill, will provide useful guidance on developing novel therapeutic targets for pain relief in OA and other MSK disorders. The proposed study presents a significant and timely expansion of the parent study. It will leverage the resources from the parent study and provide a unique opportunity to investigate relationship between joint structural damages, CNS alternations, and pain in a novel early OA model (PTOA, after orthopaedic injury and surgery). The study outcomes will provide valuable insights to MSK pain mechanisms, help identify new treatment targets for pain relief in this huge patient population, and eventually help with providing scientific solutions to battle against the ever- increasing opioid epidemic in the US.

项目概要/摘要此紧急竞争性修订是对 NIAMS 特别利益通知 (NOSI) NOT-AR-23-015 的回应。这母研究 (NIAMS R01 AR077452) 旨在开发新型定量 MRI 技术（加速 MR T1ρ 和 T2 映射）来评估前路术后患者的软骨成分变化和早期退化十字韧带重建（ACLR），是患创伤后骨关节炎的高危人群（PTOA）。在本研究中，我们旨在探索肌肉骨骼 (MSK) 疼痛的机制并确定新的治疗方法 ACL 损伤和手术后以及早期 PTOA 疼痛的成像（膝盖和大脑）标记。拟议的研究将显着扩大母研究的范围，不再只关注结构变化（“疾病”）一位评估 OA 患者症状（“疾病”，特别是疼痛）的人。通过一种新颖的多模式方法包括先进的膝盖和大脑 MRI，我们的小组将首次研究中枢神经系统 (CNS) 骨科损伤/手术后以及早期 PTOA 中疼痛的变化。研究结果将提供关键初步数据来制定 MSK 疼痛的具体假设，并将开发新颖的成像技术可用于未来骨科损伤/手术后疼痛机制的大规模研究以及 OA/PTOA，一个研究不足且临床需求紧迫的领域。因此，拟议的研究符合 NOSI 目标 A：为未来的创新研究或新的科学方向提供支持证据在新型疼痛成像技术感兴趣的领域进行肌肉骨骼疾病的疼痛研究。 OA 影响着美国 30 多万人和全球 3 亿多人。它呈现出巨大的健康和医疗保健费用和工作损失等社会经济负担。疼痛是显着损害的主要因素生活质量，导致残疾，并促使患者进行临床就诊并最终进行全关节置换术办公自动化。用于治疗严重 OA/PTOA 疼痛和骨科损伤后疼痛的阿片类药物处方很常见，由于其流行率很高，对国家阿片类药物危机造成了重大影响。更好的了解受伤/手术后和 OA/PTOA 疼痛的机制并识别生物标志物与 MSK 疼痛相关或预测 MSK 疼痛是拟议研究旨在填补的空白，将为以下方面提供有用的指导：开发缓解 OA 和其他 MSK 疾病疼痛的新治疗靶点。拟议的研究提出家长研究的重大和及时的扩展。它将利用家长研究的资源提供了一个独特的机会来研究关节结构损伤、中枢神经系统改变和新型早期 OA 模型（PTOA，骨科损伤和手术后）中的疼痛。研究成果将提供对 MSK 斯隆疼痛机制的宝贵见解，有助于确定缓解疼痛的新治疗目标庞大的患者群体，并最终帮助提供科学的解决方案来对抗日益严重的疾病美国阿片类药物流行日益严重。