Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry

多供应商多站点新型加速 MRI 松弛测量

基本信息

批准号：
10861563
负责人：
Xiaojuan Li
金额：
$ 30.59万
依托单位：
CLEVELAND CLINIC LERNER COM-CWRU
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-15 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10861563
关键词：
Acceleration Acute Affect Age Area Body mass index Brain Caring Cartilage Chronic Clinical Coupled Data Degenerative polyarthritis Disease Economic Burden Evaluation Functional Magnetic Resonance Imaging Future Goals Health Care Costs High Prevalence Image Imaging technology Immune system Impairment Injury Investigation Joints Knee Knee Injuries Knee Osteoarthritis Knee joint Magnetic Resonance Imaging Maps Methods Modeling Morbidity - disease rate Musculoskeletal Diseases Musculoskeletal Pain National Institute of Arthritis, and Musculoskeletal, and Skin Diseases Nature Nervous System Neuropathy Nociception Nociceptors Onset of illness Operative Surgical Procedures Orthopedics Outcome Outcome Study Pain Pain Research Pain management Parents Pathogenicity Patient Outcomes Assessments Patients Pattern Persons Play Population Prevalence Process Quality of life Questionnaires Replacement Arthroplasty Reporting Resources Role Site Structure Symptoms System Techniques Time Tissues Traumatic Arthropathy Vendor Visit Work anterior cruciate ligament injury anterior cruciate ligament reconstruction anterior cruciate ligament rupture arthropathies biomarker identification brain magnetic resonance imaging cohort cost disability experience health economics high risk imaging biomarker imaging study improved infancy innovation insight interest joint injury knee pain multimodality neural neuroimaging neuromechanism new therapeutic target novel novel imaging technique novel therapeutic intervention opioid epidemic osteoarthritis pain pain relief painful neuropathy patient population persistent symptom predictive marker prescription opioid radiomics sex socioeconomics

项目摘要

PROJECT SUMMARY/ABSTRACT This urgent competitive revision responds to NIAMS Notice of Special Interest (NOSI) NOT-AR-23-015. The parent study (NIAMS R01 AR077452) aims to develop novel quantitative MRI techniques (accelerated MR T1ρ and T2 mapping) to evaluate cartilage compositional changes and early degeneration in patients after anterior cruciate ligament reconstruction (ACLR), a population at high risk of developing post-traumatic osteoarthritis (PTOA). In this study, we aim to explore the mechanisms in musculoskeletal (MSK) pain and identify novel imaging (knee and brain) markers for pain after ACL injury and surgery, and at early PTOA. The proposed study will significantly expand the scope of the parent study from only focusing on structural changes (‘disease’) to one evaluating patient symptoms (‘illness’, in particular pain) in OA. With a novel multi-modal approach that includes advanced knee and brain MRI, our group will, for the first time, investigate central neural system (CNS) alterations in pain post orthopaedic injury/surgery, and in early PTOA. The study outcomes will provide critical preliminary data to formulate specific hypotheses for MSK pain, and will develop novel imaging techniques that can be utilized for future large-scale studies of pain mechanisms following orthopaedic injury/surgery and in OA/PTOA, an under-investigated area with pressing clinical needs. As such, the proposed study is aligned with the NOSI Goal A: Generate supporting evidence towards a future innovative study or new scientific direction in pain research in musculoskeletal diseases, in the areas of interest of novel pain imaging technologies. OA affects 30+ million people in the US and 300+ million people worldwide. It presents tremendous health and socioeconomic burdens with health care costs and work loss. Pain is the major factor that significantly impairs quality of life, leads to disability, and prompts patients for clinical visits and eventually total joint arthroplasty for OA. Opioid prescriptions for severe OA/PTOA pain and pain after orthopaedic injury are common, which constitutes a significant contribution to the national opioid crisis due to its high prevalence. A better understanding of the mechanisms of post-injury/surgery and OA/PTOA pains and identifying biomarkers that are associated with or predict MSK pain, the gap the proposed study aims to fill, will provide useful guidance on developing novel therapeutic targets for pain relief in OA and other MSK disorders. The proposed study presents a significant and timely expansion of the parent study. It will leverage the resources from the parent study and provide a unique opportunity to investigate relationship between joint structural damages, CNS alternations, and pain in a novel early OA model (PTOA, after orthopaedic injury and surgery). The study outcomes will provide valuable insights to MSK pain mechanisms, help identify new treatment targets for pain relief in this huge patient population, and eventually help with providing scientific solutions to battle against the ever- increasing opioid epidemic in the US.

项目摘要/摘要这种紧急的竞争性修订响应对NIAM的特殊利益通知（NOSI）非AR-23-015。这家长研究（NIAMS R01 AR077452）旨在开发新的定量MRI技术（加速的MRT1ρ 和T2映射），以评估前患者的软骨组成变化和早期变性交叉韧带重建（ACLR），这是一种患有创伤后骨关节炎的高风险的人群（PTOA）。在这项研究中，我们旨在探索肌肉骨骼（MSK）疼痛的机制并确定新颖 ACL受伤和手术后以及PTOA早期的成像（膝盖和大脑）标记。提议研究将显着扩大父母研究的范围，从仅关注结构变化（“疾病”）在OA中评估一个评估患者症状（尤其是疾病，尤其是疼痛）。采用一种新颖的多模式方法包括高级膝盖和大脑MRI，我们的小组将首次研究中央神经系统（CNS）骨科损伤/手术后以及PTOA早期的疼痛改变。研究结果将提供关键初步数据以制定MSK疼痛的特定假设，并将开发出新颖的成像技术可以用于对骨科损伤/手术后的疼痛机制的未来大规模研究以及 OA/PTOA，一个不足的临床需求的不受欢迎的区域。因此，提出的研究与 NOSI目标A：为未来的创新研究或新的科学方向生成支持证据新型疼痛成像技术感兴趣的领域，肌肉骨骼疾病的疼痛研究。 OA在美国影响300多人和全球300万人。它带来了巨大的健康和社会经济伯恩斯（Burnens）具有医疗保健成本和工作损失。疼痛是严重损害的主要因素生活质量，导致残疾，并提示患者进行临床就诊，有时是全部关节置换术 OA。严重的OA/PTOA疼痛和骨质损伤后的阿片类药物处方很常见，这是由于其高流行，对国家阿片类药物危机构成了重大贡献。更好了解伤害后/手术和OA/PTOA疼痛的机制，并识别生物标志物与MSK疼痛相关或预测MSK疼痛，拟议的研究旨在填补的差距将为有关为OA和其他MSK疾病的疼痛缓解新型热靶标。拟议的研究呈现父母研究的重大及时扩展。它将利用家长研究中的资源，并提供了一个独特的机会，可以调查联合结构损害，中枢神经系统替代方案与新型OA模型（PTOA，骨科损伤和手术后）的疼痛。研究结果将提供对MSK疼痛机制的有价值的见解，有助于确定新的治疗目标缓解疼痛庞大的患者人数，有时有助于提供科学解决方案，以应对不断的在美国增加阿片类药物的流行。