Scientist Training in Rheumatology Research

风湿病学研究科学家培训

• 批准号: 10851080
• 负责人: Jason Knight
• 金额: $ 16.94万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-12 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10851080
• 关键词: Research; Rheumatology; Scientist; Training

PROJECT SUMMARY/ABSTRACT This application is for an administrative supplement to the University of Michigan's Program for Scientist Training in Rheumatology Research (T32AR007080). Our Program, funded by NIAMS since 1975, is designed to prepare outstanding postdoctoral scientists, both MD and PhD, for investigative careers in research related to rheumatic diseases. Our Program is motivated by several key factors including (i) the tremendous clinical need caused by the unrelenting burden of rheumatic diseases; (ii) an appreciation that rheumatic diseases are propelled by complex processes in need of multidisciplinary approaches; and (iii) a threatened pipeline of diverse investigators committed to careers that will be devoted to rheumatology research. The short-term goal of this administrative supplement is to provide increased opportunities for training focused on the study of the mechanisms, measurement, and treatment of pain within our existing NIAMS T32 Training Program. The long-term goal is to develop a diverse research workforce that has the skills and content expertise needed to address the existing gaps in these areas. The goal of Aim 1 is to develop new, scalable educational activities that will allow trainees (both internal and external) to gain the knowledge and experience necessary to integrate the study of pain into their research careers. Specifically, a team led by Dr. David Williams (contact PI for the National HEAL K12 Program) will convert their highly successful University of Michigan course, Introduction to Pain: Mechanisms, Measurement, and Treatment, into an online curriculum designed to keep pace with the everchanging field of clinical pain research. This version 1.0 will be the foundational curriculum for K and T32 pain scholars at the University of Michigan, as well as nationally through the Positively Uniting Researchers of Pain to Opine, Synthesize, & Engage (PURPOSE) network. The goal of Aim 2 is to add an additional trainee to our existing Program. We have identified a highly qualified candidate, Dr. Jacob Aday, who will begin training with one of our existing mentors, Dr. Daniel Clauw. Within the scope of our Program, Drs. Aday and Clauw have conceived an innovative project developed around a cutting-edge clinical trial of psychedelic-assisted therapy for fibromyalgia. Dr. Aday is committed to pursuing a career as a pain researcher under the NIAMS mission and has developed a plan for the experiential learning, coursework, and mentorship that are necessary for him to achieve his timely goal.

项目总结/摘要 此申请是密歇根大学科学家项目的行政补充 流变学研究培训（T32 AR 007080）。自1975年以来，我们的计划由NIAMS资助， 旨在培养优秀的博士后科学家，无论是医学博士和博士，为调查事业， 与风湿性疾病有关的研究。我们的计划是由几个关键因素，包括（i） 巨大的临床需求所造成的无情的负担风湿性疾病;（ii）赞赏， 风湿性疾病是由需要多学科方法的复杂过程推动的;和（iii） 致力于风湿病学事业的各种研究人员的威胁管道 research.这一行政补充的短期目标是提供更多的机会 培训重点是研究我们内部疼痛的机制、测量和治疗 现有的NIAMS T32培训计划。长期目标是发展多样化的研究队伍 拥有解决这些领域现有差距所需的技能和内容专门知识。 目标1的目标是开发新的、可扩展的教育活动，使受训者（内部和 外部）获得必要的知识和经验，将疼痛的研究纳入他们的研究 careers.具体而言，由大卫威廉姆斯博士（联系PI了解国家治愈K12计划）领导的团队将 将他们非常成功的密歇根大学课程，疼痛介绍：机制，测量， 和治疗，成为一个在线课程，旨在跟上不断变化的临床疼痛领域 research.这个版本1.0将是基础课程的K和T32疼痛学者在大学 密歇根州，以及全国通过积极团结研究人员的痛苦，以意见，合成， 参与（目的）网络。 目标2的目标是为我们现有的培训计划增加一名学员。我们已经找到了一个非常有资格的 候选人，雅各布·阿迪博士，谁将开始与我们现有的导师之一，丹尼尔克劳博士培训。内 Aday和Clauw博士构思了一个创新项目， 纤维肌痛致幻剂辅助治疗的前沿临床试验Aday博士致力于寻求 作为NIAMS使命下的疼痛研究员，并制定了体验式学习计划， 课程作业和指导，这是必要的，他实现他的及时目标。

项目成果

Breast calcinosis in a patient with Dermatomyositis.

皮肌炎患者的乳房钙质沉着。

• DOI: 10.5152/eurjrheum.2016.15080
• 发表时间: 2017
• 期刊: European journal of rheumatology
• 影响因子: 1.9
• 作者: Namas,Rajaie;Beydoun,Nassar;Meysami,Alireza
• 通讯作者: Meysami,Alireza

Brief Report: Drugs Implicated in Systemic Autoimmunity Modulate Neutrophil Extracellular Trap Formation.

• DOI: 10.1002/art.40372
• 发表时间: 2018-03
• 期刊: Arthritis & rheumatology (Hoboken, N.J.)
• 作者: Irizarry-Caro JA;Carmona-Rivera C;Schwartz DM;Khaznadar SS;Kaplan MJ;Grayson PC
• 通讯作者: Grayson PC

Myeloid-Specific Deletion of Peptidylarginine Deiminase 4 Mitigates Atherosclerosis.

• DOI: 10.3389/fimmu.2018.01680
• 发表时间: 2018
• 期刊: Frontiers in immunology
• 影响因子: 7.3
• 作者: Liu Y;Carmona-Rivera C;Moore E;Seto NL;Knight JS;Pryor M;Yang ZH;Hemmers S;Remaley AT;Mowen KA;Kaplan MJ
• 通讯作者: Kaplan MJ

Fucosyltransferase 1 mediates angiogenesis in rheumatoid arthritis.

岩藻糖基转移酶1介导类风湿关节炎中的血管生成。

• DOI: 10.1002/art.38648
• 发表时间: 2014-08
• 期刊: ARTHRITIS & RHEUMATOLOGY
• 影响因子: 13.3
• 作者: Isozaki, Takeo;Amin, Mohammad A.;Ruth, Jeffrey H.;Campbell, Phillip L.;Tsou, Pei-Suen;Ha, Christine M.;Stinson, W. Alex;Domino, Steven E.;Koch, Alisa E.
• 通讯作者: Koch, Alisa E.

Dysregulated neutrophil responses and neutrophil extracellular trap formation and degradation in PAPA syndrome.

• DOI: 10.1136/annrheumdis-2018-213746
• 发表时间: 2018-12
• 期刊: Annals of the rheumatic diseases
• 影响因子: 27.4
• 作者: Mistry P;Carmona-Rivera C;Ombrello AK;Hoffmann P;Seto NL;Jones A;Stone DL;Naz F;Carlucci P;Dell'Orso S;Gutierrez-Cruz G;Sun HW;Kastner DL;Aksentijevich I;Kaplan MJ
• 通讯作者: Kaplan MJ