Scientist Training in Rheumatology Research

风湿病学研究科学家培训

• 批准号: 10627099
• 负责人: Jason Knight
• 金额: $ 35.34万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10627099
• 关键词: Research; Rheumatology; Scientist; Training

PROJECT SUMMARY / ABSTRACT This application is a competitive renewal of the University of Michigan's Program for Scientist Training in Rheumatology Research (T32AR007080). Our Program, funded by NIAMS since 1975, is designed to prepare four outstanding postdoctoral scientists per year, both MD and PhD, for investigative careers in research related to the rheumatic diseases. Our Program is motivated by several key factors including (i) the tremendous clinical need caused by the unrelenting burden of rheumatic diseases; (ii) an appreciation that rheumatic diseases are propelled by complex processes in need of multidisciplinary approaches; and (iii) a threatened pipeline of diverse investigators committed to careers that will be devoted to rheumatology research. Fortunately, recent advances in biomedical and clinical sciences have created unprecedented research opportunities to understand disease etiologies more deeply—and ultimately improve outcomes through an approach personalized to the care of each individual living with a rheumatic disease. Our 22 Program faculty mentors are dedicated researcher-mentors who together bring broad interdisciplinary expertise focused on rheumatic diseases. These investigators have established extensive collaborations with research units nationally and internationally to effectively study rheumatic disease mechanisms and improve management. Leveraging these historical strengths, our Program's themes have been updated to align with NIAMS strategic mission “to transcend disease- and tissue-specific boundaries via cross-cutting scientific themes.” For the upcoming cycle of our Program, major scientific themes will include (i) Biologic Underpinnings of Clinical Heterogeneity; (ii) Immunological Mechanisms of Disease; (iii) Injury, Repair, and Fibrosis; and (iv) Patient Outcomes/Experience and Innovative Trials. Trainees are also provided strong roots in the ethical conduction of research, and in embracing a culture of diversity, equity, and inclusion. Some additional highlights of the Training Program include: (i) the availability of an award-winning 10-week research training course offered to physician trainees with a strong interest in basic research; (ii) multiple paths for trainees to earn a master's degree concurrent with their Program training, and (iii) outstanding state-of-the-art biomedical cores that provide training, consultations, and scientific services commensurate with U-M's standing as the top public research institution in the United States. It has been a longstanding mission of our Program to train individuals from diverse backgrounds for careers in research. Of the 26 trainees since 2009, 17 (65%) are women and eight (31%) come from underrepresented backgrounds (1 Black, 5 Hispanic or Latinx, and 2 from disadvantaged backgrounds); half of the current trainees identify as underrepresented minorities. Of the 20 trainees (9 MD and 11 PhD) who have completed their participation in our Program since 2011, all 20 remain involved in research. Fourteen of the 20 (70%) are working in research-intensive careers, and ten have successfully competed for grant funding (~70 grants have been awarded to the group as PI).

项目总结/摘要 这个应用程序是密歇根大学的科学家培训计划的竞争性更新， 流变学研究（T32 AR 007080）。自1975年以来，我们的计划由NIAMS资助，旨在 每年培养四名优秀的博士后科学家，包括MD和PhD，从事以下研究工作： 与风湿性疾病有关的研究。我们的计划是由几个关键因素，包括（i） 巨大的临床需求所造成的无情的负担风湿性疾病;（ii）赞赏， 风湿性疾病是由需要多学科方法的复杂过程推动的;和（iii） 致力于风湿病学事业的各种研究人员的威胁管道 research.幸运的是，生物医学和临床科学的最新进展创造了前所未有的 研究机会，以更深入地了解疾病的病因，并最终改善结果 通过个性化的方法来照顾每个患有风湿性疾病的人。我们22 项目教师导师是专门的研究导师，他们共同带来了广泛的跨学科 专注于风湿性疾病的专业知识。这些研究人员已经建立了广泛的合作， 研究单位国内和国际上有效地研究风湿性疾病的机制，并提高 管理利用这些历史优势，我们的计划主题已经更新，以符合 NIAMS的战略使命是“通过跨领域的科学研究， 主题”。对于我们计划的下一个周期，主要科学主题将包括（i）生物基础 （ii）疾病的免疫机制;（iii）损伤、修复和纤维化;以及（iv） 患者结局/经验和创新试验。学员还提供了坚实的基础，在道德 进行研究，并拥抱多样性，公平和包容的文化。一些额外 培训计划的重点包括：（i）提供为期10周的获奖研究培训 为对基础研究有浓厚兴趣的医生学员提供的课程;（ii）为学员提供多种途径， 获得硕士学位的同时，他们的计划培训，和（iii）杰出的国家的最先进的生物医学 核心，提供培训，咨询和科学服务与密歇根大学的地位，作为最高的 美国的公共研究机构。我们项目的长期使命是 来自不同背景的人在研究的职业生涯。自2009年以来的26名受训人员中，17人（65%）是 女性和8名（31%）来自代表性不足的背景（1名黑人，5名西班牙裔或拉丁裔， 2名来自弱势背景）;目前的受训人员中有一半认为自己是代表性不足的少数群体。的 自2011年以来，20名学员（9名医学博士和11名博士）已经完成了对我们计划的参与，所有20名学员都是在2012年完成的。 继续参与研究。这20人中有14人（70%）从事研究密集型职业， 成功竞争赠款资金（约70笔赠款已授予该集团作为PI）。