Training of Arthritis Research Scientists

摘要 风湿性和自身免疫性疾病仍然知之甚少，难以管理和治疗，而且往往 导致显著的发病率和死亡率。只有注重研究，才能改变这一现状 努力建立和推进已经产生的知识，重新评估当前的教条， 并利用跨学科的合作方法，有效地了解这些复杂的 多系统疾病。基因组学、表观基因组学和系统生物学的科学发展， 从根本上增强了我们对人类生物学的理解，并产生了丰富的数据和独特的 有机会全面研究人类自身免疫性疾病的机制。此外，本发明还 临床科学的进步为改善患者的治疗效果创造了极好的研究机会。 该培训补助金的目标是为下一代研究人员独立做好准备 研究人员，并领导未来的努力，以改善受风湿性和自身免疫性疾病影响的患者的护理 疾病这将通过选择最有前途的博士后实习生候选人来实现， 为他们提供至少两年的拟议培训期的知识和技能， 为了独立我们的培训计划每年将包括4名医生-科学家或科学家， 通过精心设计的个性化教学体验，以及结构化的指导，为他们做好准备 专注于科学和职业发展。此外，我们的计划将准备学员的独立性 通过科学写作、语法和领导技能的培训。该培训计划将 由Amr Sawalha博士指导，大卫福克斯博士和Dinesh卡纳博士担任副主任。在一起，这 培训赠款领导，由外部咨询委员会支持，其中包括4名科学领导人， 丰富的生产力和指导经验，提供了一套互补的专业知识，以确保 成功的指导计划侧重于基础、转化和临床研究。培训计划 促进跨学科的研究，这是由经验丰富的程序教师导师名册明显 跨越15个不同的单元它得到了丰富多样的科学环境的支持， 密歇根大学，包括两个NIH资助的自身免疫卓越中心（ACE）计划- a 基础ACE和临床ACE -证明我们在基础和临床研究方面的实力。我们的培训 计划将集中在六大科学主题：基因组学，表观基因组学和生物信息学;系统性狼疮 红斑;炎性关节炎;系统性硬化症;纤维肌痛和慢性疼痛;和卫生保健政策 结果研究。对风湿性和自身免疫性疾病的研究人员有很大的需求， 迫切需要确保未来的独立研究人员得到良好的培训和装备，以领导 努力了解这些疾病的复杂性，确定新的治疗方案，并改善患者的 成果。事实上，我们提出的培训方案全面满足了这些需求。

ABSTRACT Rheumatic and autoimmune diseases remain poorly understood, are difficult to manage and treat, and often result in significant morbidity and mortality. This status quo can only be changed by focusing on research efforts that build upon and advance the knowledge that has been generated, re-evaluating current dogmas, and taking advantage of an interdisciplinary collaborative approach to effectively understand these complex multi-system diseases. Unparalleled scientific expansion in genomics, epigenomics, and systems biology has fundamentally enhanced our understanding of human biology, and generated a wealth of data and a unique opportunity to comprehensively investigate the mechanisms underlying human autoimmune diseases. Further, advances in clinical sciences have created outstanding research opportunities to improve patient outcomes. The goal of this Training Grant is to prepare the next generation of researchers to become independent investigators, and lead future efforts to improve care of patients affected by rheumatic and autoimmune diseases. This will be accomplished by selecting the most promising postdoctoral trainee candidates, and providing them with the knowledge and skills for a proposed training period of at least 2 years to prepare them for independence. Our Training Program will include 4 physician-scientists or scientists each year and will prepare them through a carefully designed individualized didactic experience, with structured mentoring focused on both scientific and career growth. In addition, our program will prepare trainees for independence through training in scientific writing, grantsmanship, and leadership skills. This Training Program will be directed by Dr. Amr Sawalha, with Drs. David Fox and Dinesh Khanna as Associate Directors. Together, this Training Grant leadership, supported by an external advisory committee which includes 4 scientific leaders with extensive productivity and mentoring experience, provides a complementary set of expertise to ensure a successful mentoring program focused on basic, translational, and clinical research. The Training Program fosters interdisciplinary research, which is evident by a roster of experienced Program Faculty mentors spanning 15 different units. It is supported by a rich and diverse scientific environment to study autoimmunity at the University of Michigan, including two NIH-funded Autoimmunity Centers of Excellence (ACE) programs – a Basic ACE and a Clinical ACE – attesting to our strength in both basic and clinical research. Our Training Program will focus on six major scientific themes: genomics, epigenomics, and bioinformatics; systemic lupus erythematosus; inflammatory arthritis; systemic sclerosis; fibromyalgia and chronic pain; and health care policy and outcome research. There is a significant need for researchers in rheumatic and autoimmune diseases, and a pressing need for making sure that future independent researchers are well trained and equipped to lead the effort to understand the complexity of these diseases, identify novel therapeutic options, and improve patient outcomes. Indeed, our proposed Training Program comprehensively addresses these needs.