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Technology for MR brain monitoring

MR脑部监测技术

基本信息

批准号：
10861524
负责人：
Lawrence L Wald
金额：
$ 60.2万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-01 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10861524
关键词：
Abscess Accident and Emergency department Acoustics Ambulances Articulation Beds Brain Brain Diseases Brain Edema Brain Injuries Brain Neoplasms Brain imaging Brain region Caring Cerebrum Clinical Detection Devices Diagnosis Diagnostic Diagnostic Equipment Diameter Diffusion Edema Emergency Care Emergency Medicine Environment FDA approved Geometry Goals Head Height Helmet Hemorrhage Hockey Hour Image Imaging Device Intensive Care Units Intracranial Hemorrhages Intracranial Hypertension Intracranial Pressure Learning Life Location Magnetic Resonance Imaging Maintenance Methods Monitor Neoplasms Nervous System Trauma Neurologic Noise Obstruction Operative Surgical Procedures Patient Monitoring Patients Pharmaceutical Preparations Physiologic pulse RF coil Relaxation Resolution Scanning Shapes Site Sports System Technology Testing Time Transducers Trauma Ventricular Weight Work arm brain magnetic resonance imaging cohort cost design detection platform detector improved light weight magnetic field monitoring device nervous system disorder novel novel strategies patient monitoring device point of care portability power consumption programs prototype rural healthcare standard of care temporal measurement tool ventilation

项目摘要

Project Summary/Abstract: Technology for MR brain monitoring Magnetic Resonance Imaging (MRI) has been the undisputed standard of care for the detection and diagnosis of neurological disorders and injuries since its inception over 4 decades ago. The cost, weight, size, and maintenance needs of MRI scanners, however, typically precludes their use in some locations with perhaps the greatest need - including Emergency Departments, Neurological Intensive Care Units (ICUs), surgical suites, sports fields, battlefields, rural healthcare sites, and ambulances. This has started to change with the emergence of low-field “point-of-care” scanners, such as those developed by our group and others. Still, even these mobile units are not designed to be used as a patient monitoring device akin to how a pulse-oximeter is used. A new approach is needed to create a true “brain monitor” using MRI. In this work, build on our proof-of-concept prototype 7 kg brain monitor, the “MR Cap” to develop and evaluate an inexpensive device that can be deployed, not bedside, but within the patient bed. Once in place, the device can acquire imaging information at regular intervals and alert the care team to changes associated with increased intracranial pressure or hemorrhage. To achieve this, we relax magnetic field strength and homogeneity constraints to allow lightweight, permanent magnet designs (our prototype is 7 kg) that can be held by an articulating arm with no cryogens or power consumption. We achieve image encoding and eliminate the heavy, power consuming readout gradient by using a built-in gradient requiring no additional power and producing no acoustic noise. We propose passive and active external interference mitigation methods to eliminate the need for a shielded room. We will validate the scanners ability to monitor for and detect cerebral mass effects in the ED and ICU.

项目摘要/摘要：磁共振脑监测技术