Technology for MR brain monitoring

MR脑部监测技术

• 批准号: 10861524
• 负责人: Lawrence L Wald
• 金额: $ 60.2万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10861524
• 关键词: Abscess; Accident and Emergency department; Acoustics; Ambulances; Articulation; Beds; Brain; Brain Diseases; Brain Edema; Brain Injuries; Brain Neoplasms; Brain imaging; Brain region; Caring; Cerebrum; Clinical; Detection; Devices; Diagnosis; Diagnostic; Diagnostic Equipment; Diameter; Diffusion; Edema; Emergency Care; Emergency Medicine; Environment; FDA approved; Geometry; Goals; Head; Height; Helmet; Hemorrhage; Hockey; Hour; Image; Imaging Device; Intensive Care Units; Intracranial Hemorrhages; Intracranial Hypertension; Intracranial Pressure; Learning; Life; Location; Magnetic Resonance Imaging; Maintenance; Methods; Monitor; Neoplasms; Nervous System Trauma; Neurologic; Noise; Obstruction; Operative Surgical Procedures; Patient Monitoring; Patients; Pharmaceutical Preparations; Physiologic pulse; RF coil; Relaxation; Resolution; Scanning; Shapes; Site; Sports; System; Technology; Testing; Time; Transducers; Trauma; Ventricular; Weight; Work; arm; brain magnetic resonance imaging; cohort; cost; design; detection platform; detector; improved; light weight; magnetic field; monitoring device; nervous system disorder; novel; novel strategies; patient monitoring device; point of care; portability; power consumption; programs; prototype; rural healthcare; standard of care; temporal measurement; tool; ventilation

Project Summary/Abstract: Technology for MR brain monitoring Magnetic Resonance Imaging (MRI) has been the undisputed standard of care for the detection and diagnosis of neurological disorders and injuries since its inception over 4 decades ago. The cost, weight, size, and maintenance needs of MRI scanners, however, typically precludes their use in some locations with perhaps the greatest need - including Emergency Departments, Neurological Intensive Care Units (ICUs), surgical suites, sports fields, battlefields, rural healthcare sites, and ambulances. This has started to change with the emergence of low-field “point-of-care” scanners, such as those developed by our group and others. Still, even these mobile units are not designed to be used as a patient monitoring device akin to how a pulse-oximeter is used. A new approach is needed to create a true “brain monitor” using MRI. In this work, build on our proof-of-concept prototype 7 kg brain monitor, the “MR Cap” to develop and evaluate an inexpensive device that can be deployed, not bedside, but within the patient bed. Once in place, the device can acquire imaging information at regular intervals and alert the care team to changes associated with increased intracranial pressure or hemorrhage. To achieve this, we relax magnetic field strength and homogeneity constraints to allow lightweight, permanent magnet designs (our prototype is 7 kg) that can be held by an articulating arm with no cryogens or power consumption. We achieve image encoding and eliminate the heavy, power consuming readout gradient by using a built-in gradient requiring no additional power and producing no acoustic noise. We propose passive and active external interference mitigation methods to eliminate the need for a shielded room. We will validate the scanners ability to monitor for and detect cerebral mass effects in the ED and ICU.

项目总结/摘要：MR脑监测技术 磁共振成像（MRI）一直是无可争议的标准护理检测 自40多年前成立以来，一直致力于神经系统疾病和损伤的诊断。成本， 然而，MRI扫描仪的重量、尺寸和维护需求通常排除了它们在一些应用中的使用。 可能最需要的地方-包括急诊科，神经强化 监护室（ICU）、手术室、运动场、战场、农村医疗站点和救护车。 随着低场“床旁”扫描仪的出现，这种情况已经开始改变， 由我们的团队和其他人开发。尽管如此，即使是这些移动的单元也不是设计用来作为 类似于如何使用脉搏血氧计的患者监测设备。需要一种新的方法来创造 一个真正的“大脑监视器”使用核磁共振成像。 在这项工作中，建立在我们的概念验证原型7公斤大脑监测器，“MR帽”开发 并评估一种廉价的设备，该设备可以部署在病床内，而不是床边。 一旦到位，该设备可以定期获取成像信息，并提醒护理团队 与颅内压升高或出血相关的变化。为了实现这一点，我们放松 磁场强度和均匀性约束，以允许轻质永磁体设计 (our原型是7公斤），可以举行一个关节臂没有冷冻剂或电力 消费我们实现了图像编码，消除了沉重的，功耗读出 通过使用不需要额外功率且不产生声学噪声的内置梯度来实现梯度。 我们提出了被动和主动的外部干扰缓解方法，以消除需要一个 屏蔽室我们将验证扫描仪监测和检测脑质量效应的能力， 艾德和重症监护室