System Upgrade for Siemens 7T Human MRI System

7.项目摘要/摘要 此应用程序寻求ORIP高端仪器(HEI)赠款计划的支持，以资助一个新的 西门子7特斯拉全身人体核磁共振扫描仪将用于基础/临床/翻译研究 阿蒂努拉·A·马蒂诺斯生物医学成像中心，升级我们现有的原型7特斯拉扫描仪。这 系统将作为我们现有的已有15年历史的原型7特斯拉核磁共振扫描仪的升级，并将提供 马蒂诺斯中心发现的广泛研究的性能大幅提高， 包括：临床和神经放射学研究；认知、精神病学和基础神经科学和脑科学 测绘研究；以及新仪器的开发。而马提诺酒店的7T研究项目 中心近年来非常成功，我们的7T磁铁不再由 制造商，扫描仪不再受制造商支持，因此我们计划退役 我们目前的系统在未来3-4年内。因为新品7T的独特功能 核磁共振，拟议的西门子7特斯拉人体核磁共振系统升级将不仅仅取代我们现有的扫描仪 但将提供新的功能以提高性能和数据质量，这将使现有项目受益，并且 这肯定是一项使能技术，它将补充马蒂诺斯中心的传统核磁共振扫描仪。 与我们现有的原型系统相比，此次升级提供的功能和优势包括： 和标准化工作流，以实现更好的易用性，从而实现更广泛的用户基础以及健壮性和 跨会话的一致性；标准化的硬件和软件与其他站点兼容，支持 新的协作大型多站点试验；改进了对产品的制造商支持和维护 系统向前发展，减轻了目前给马蒂诺斯中心工作人员带来的负担；增强了系统 性能包括射频接收通道，更强的梯度线圈，更高阶的磁场垫片， 更高的射频功率、更快的图像重建计算机、高时间分辨率生理 监控，以及与新发布的西门子兼容的新序列和应用程序包 平台；以及独一无二的仪器和技术研发的最新试验台 在Martinos中心进行，包括先进的成像序列和重建，密度更高 接收线圈阵列和垫片-射频多线圈阵列将与我们的行业合作伙伴共享，并免费提供 传播到核磁共振社区。通过为小灵通资助的高生产率跨学科小组提供服务 调查人员说，这一拟议的升级将增强现有的研究计划，同时促进 新项目和协作出现并蓬勃发展的机会。因此，此工具升级将 帮助为其他由PHS资助的研究中心使用这些下一代MRI技术铺平道路，Will 有助于证明7T MRI在临床上的实用性和实用性，并将为我们提供 具有创新临床、翻译和基础研究所需的技术优势的研究人员。

7. PROJECT SUMMARY/ABSTRACT This application seeks support from the ORIP High-End Instrumentation (HEI) Grant program to fund a new Siemens 7 Tesla whole-body human MRI scanner to be used for basic/clinical/translational research at the Athinoula A. Martinos Center for Biomedical Imaging, to upgrade our existing prototype 7 Tesla scanner. This system will serve as an upgrade of our existing, 15-year-old prototype 7 Tesla MRI scanner, and will provide an substantial increase of performance for the wide range of research found at the Martinos Center, including: clinical and neuroradiological studies; cognitive, psychiatric, and basic neuroscience and brain mapping studies; and novel instrumentation development. While the 7T research program at the Martinos Center has been very successful in recent years, our 7T magnet is no longer serviceable by the manufacturer, the scanner is no longer supported by the manufacturer, and therefore we plan to retire our current system within the next 3–4 years. Because of the unique capabilities of the new product 7T MRI, the proposed Siemens 7 Tesla Human MRI System Upgrade will not merely replace our existing scanner but will offer new features for improved performance and data quality that will benefit existing projects, and is sure to be an enabling technology that will complement the conventional MRI scanners at the Martinos Center. The features and benefits provided by this upgrade over our existing prototype system include: streamlined and standardized workflows for greater ease of use, enabling a broader user base as well as robustness and consistency across sessions; standardized hardware and software for compatibility with other sites, enabling new, collaborative large-scale multi-site trials; improved manufacturer support and maintenance for a product system moving forward, reducing the burden currently placed on Martinos Center staff; enhanced system performance including 64 RF receiver channels, stronger gradient coils, higher-order magnetic field shims, increased RF power, a faster image reconstruction computer, high-temporal-resolution physiological monitoring, and new sequence and application packages compatible with the newly released Siemens platform; and an up-to-date testbed for the unique instrumentation and technology research and development performed at the Martinos Center, including advanced imaging sequences and reconstruction, higher-density receive coil arrays, and shim-RF multi-coil arrays to be both shared with our industrial collaborators and freely disseminated to the MRI community. By serving a highly productive interdisciplinary group of PHS-funded investigators, this proposed upgrade will enhance existing research programs while at the same time fostering opportunities for new projects and collaborations to emerge and flourish. This instrumentation upgrade will thus help pave the way for other PHS-funded research centers to use these next-generation MRI technologies, will help demonstrate the utility and practicality of 7T MRI for its inevitable use in the clinic, and will provide our investigators with a technological edge required for innovative clinical, translational, and basic research.