System Upgrade for Siemens 7T Human MRI System

7.项目总结/摘要 该申请寻求ORIP高端仪器（HEI）资助计划的支持，以资助一个新的 西门子7特斯拉全身人体MRI扫描仪将用于基础/临床/转化研究 阿提努拉湖Martinos生物医学成像中心，升级我们现有的原型7特斯拉扫描仪。这 该系统将作为我们现有的，15岁的原型7特斯拉MRI扫描仪的升级，并将提供 在马蒂诺斯中心发现的广泛研究的性能大幅提高， 包括：临床和神经放射学研究;认知，精神病学和基础神经科学和脑 测绘研究和新型仪器开发。马蒂诺的7 T研究项目 中心近年来一直非常成功，我们的7 T磁铁不再适用于 由于制造商不再支持该扫描仪，因此我们计划停用 我们目前的系统在未来3-4年内。由于新产品7 T的独特功能， 磁共振成像，拟议的西门子7特斯拉人体磁共振成像系统升级将不仅取代我们现有的扫描仪 但将提供新的功能，以提高性能和数据质量，这将有利于现有的项目， 这肯定是一项使能技术，将补充传统的MRI扫描仪在马蒂诺斯中心。 与我们现有的原型系统相比，此次升级所提供的功能和优势包括： 和标准化的工作流程，以实现更大的易用性，从而实现更广泛的用户群和稳健性， 跨会话的一致性;标准化的硬件和软件，以便与其他站点兼容， 新的、协作的大规模多中心试验;改进制造商对产品的支持和维护 系统向前发展，减少目前Martinos中心工作人员的负担;增强系统 性能包括64个RF接收器通道、更强的梯度线圈、更高阶的磁场梯度， 增加的射频功率，更快的图像重建计算机，高时间分辨率的生理 监控，以及与新发布的西门子兼容的新序列和应用程序包 平台;以及用于独特仪器和技术研发的最新测试平台 在Martinos中心进行，包括先进的成像序列和重建，更高密度 接收线圈阵列和shim-RF多线圈阵列，与我们的工业合作者共享， 传播到MRI社区。通过服务于一个高效的跨学科小组， 调查人员，这一拟议的升级将加强现有的研究计划，同时促进 新项目和合作的出现和蓬勃发展的机会。因此，此次仪器升级将 有助于为其他PHS资助的研究中心使用这些下一代MRI技术铺平道路， 有助于证明7 T MRI在临床中不可避免的用途的实用性和实用性，并将提供我们的 具有创新临床、转化和基础研究所需技术优势的研究人员。

7. PROJECT SUMMARY/ABSTRACT This application seeks support from the ORIP High-End Instrumentation (HEI) Grant program to fund a new Siemens 7 Tesla whole-body human MRI scanner to be used for basic/clinical/translational research at the Athinoula A. Martinos Center for Biomedical Imaging, to upgrade our existing prototype 7 Tesla scanner. This system will serve as an upgrade of our existing, 15-year-old prototype 7 Tesla MRI scanner, and will provide an substantial increase of performance for the wide range of research found at the Martinos Center, including: clinical and neuroradiological studies; cognitive, psychiatric, and basic neuroscience and brain mapping studies; and novel instrumentation development. While the 7T research program at the Martinos Center has been very successful in recent years, our 7T magnet is no longer serviceable by the manufacturer, the scanner is no longer supported by the manufacturer, and therefore we plan to retire our current system within the next 3–4 years. Because of the unique capabilities of the new product 7T MRI, the proposed Siemens 7 Tesla Human MRI System Upgrade will not merely replace our existing scanner but will offer new features for improved performance and data quality that will benefit existing projects, and is sure to be an enabling technology that will complement the conventional MRI scanners at the Martinos Center. The features and benefits provided by this upgrade over our existing prototype system include: streamlined and standardized workflows for greater ease of use, enabling a broader user base as well as robustness and consistency across sessions; standardized hardware and software for compatibility with other sites, enabling new, collaborative large-scale multi-site trials; improved manufacturer support and maintenance for a product system moving forward, reducing the burden currently placed on Martinos Center staff; enhanced system performance including 64 RF receiver channels, stronger gradient coils, higher-order magnetic field shims, increased RF power, a faster image reconstruction computer, high-temporal-resolution physiological monitoring, and new sequence and application packages compatible with the newly released Siemens platform; and an up-to-date testbed for the unique instrumentation and technology research and development performed at the Martinos Center, including advanced imaging sequences and reconstruction, higher-density receive coil arrays, and shim-RF multi-coil arrays to be both shared with our industrial collaborators and freely disseminated to the MRI community. By serving a highly productive interdisciplinary group of PHS-funded investigators, this proposed upgrade will enhance existing research programs while at the same time fostering opportunities for new projects and collaborations to emerge and flourish. This instrumentation upgrade will thus help pave the way for other PHS-funded research centers to use these next-generation MRI technologies, will help demonstrate the utility and practicality of 7T MRI for its inevitable use in the clinic, and will provide our investigators with a technological edge required for innovative clinical, translational, and basic research.