Molecular Dissection of Mitochondria-Organelle Interactions

摘要 这是对NIH DP2ES032761的一份行政补充文件的请求，标题为《分子解剖 线粒体-细胞器相互作用“。该项目旨在识别来自其他来源的信号 正常细胞的细胞器和线粒体的调节，并针对线粒体功能障碍 治疗收益，使用创新的线粒体标记和分离策略，与成像相结合。在这 补充，我们建议确定线粒体-细胞器相互作用如何在细胞模型中发生变化。 线粒体疾病，使用高分辨率成像技术和生化方法。这 行政副刊将为任职人数不足的人员提供出色的共同指导培训经验 少数族裔学士学位持有者Francisco Miralles，他的职业目标是在一个 医学博士学位课程。

ABSTRACT This is a request for an administrative supplement for NIH DP2ES032761 titled “Molecular Dissection of Mitochondria-Organelle Interactions”. This project aims to identify the signals that originate from other organelles and regulate mitochondria in healthy cells and target them in mitochondrial dysfunction for therapeutic gain, using an innovative mitochondrial labelling and isolation strategy coupled to imaging. In this supplement, we propose to determine how of mitochondria-organelle interactions change in cellular models of mitochondrial diseases, using high resolution imaging techniques and biochemical methods. This administrative supplement will provide an outstanding co-mentored training experience of an underrepresented minority baccalaureate degree holder, Francisco Miralles, whose career goal is to continue his education in an MD/Ph.D program.