Exercising language: Behavioral and neurophysiological changes after high-intensity exercise training in post-stroke aphasia.

运动语言：中风后失语症高强度运动训练后的行为和神经生理变化。

• 批准号: 10862024
• 负责人: Maria V. Ivanova
• 金额: $ 71.25万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10862024
• 关键词: Adjuvant; Aerobic; Affect; Aftercare; Anxiety; Aphasia; Attention; Behavioral; Blood; Blood Vessels; Blood flow; Brain; Cerebrovascular Circulation; Cerebrum; Chronic; Clinical; Cognition; Cognitive; Comprehension; Dose; Effectiveness; Emotional; Evaluation; Exercise; Family; Friends; Gait; Health; Health Benefit; Individual; Intervention; Knowledge; Language; Language Disorders; Language Therapy; Lead; Learning; Life; Maintenance; Measures; Mediating; Memory; Mental Depression; Motor; Motor Skills; Names; Neuronal Plasticity; Outcome; Outcome Measure; Participant; Patients; Pattern; Performance; Perfusion; Personal Satisfaction; Persons; Physical Exercise; Physical Fitness; Physiological; Population; Production; Quality of life; Recovery; Speech; Stroke; Thinking; Treatment Protocols; Up-Regulation; Vascular blood supply; Well in self; Work; aphasia recovery; behavioral outcome; brain health; cardiorespiratory fitness; cerebrovascular; cognitive ability; cognitive benefits; cognitive enhancement; cognitive performance; cost efficient; design; executive function; exercise intensity; exercise intervention; exercise program; exercise training; fitness; improved; innovation; insight; language outcome; motor recovery; nervous system disorder; neural; neuroimaging; neurophysiology; neurovascular; novel; novel strategies; physical conditioning; post intervention; programs; psychologic; psychosocial; recruit; response; skills; sleep quality; social engagement; stroke survivor; stroke-induced aphasia; tool; traditional therapy

Project Summary/Abstract Losing the ability to speak and understand language is devastating for patients with aphasia and their families, negatively impacting multiple aspects of life and emotional well-being. Unfortunately, individuals with aphasia rarely regain their language skills in full. Novel approaches are required that boost the effects of traditional therapies, leading to better outcomes for people with aphasia. The proposed study seeks to evaluate the effects of a promising adjuvant intervention - physical exercise training - on recovery in aphasia. A new exercise program, specifically designed for individuals with post-stroke aphasia, will be the means of providing a safe, stroke- and aphasia-friendly physical exercise intervention to achieve optimal physical fitness gains. This will also be the first large scale study in aphasia to systematically examine the additive and enhancing effects of combining physical exercise training with traditional language therapy. Innovative outcome measures will include not only language and cognitive measures but also measures of motor skills and psychological and psychosocial outcomes that will assess the benefits of physical exercise. Another cutting-edge aspect of the study is the inclusion of advanced physiological fitness measures and neuroimaging metrics of blood flow and cerebrovascular reactivity as outcome measures to afford a deeper understanding of the exercise-mediated behavioral and neural effects in stroke survivors. We will recruit 110 individuals with aphasia to evaluate the multifaceted impact of exercise on behavioral and physical outcomes in isolation and in combination with traditional speech-language therapy. First, the benefits of physical exercise for language, cognition, motor, and emotional and psychological well-being in individuals with aphasia will be established. Of particular importance will be an enhanced understanding of how exercise can boost the effects of existing speech-language therapies. Second, determining how exercise-induced changes in physical fitness are related to changes in language and cognitive measures will provide insight into key ingredients of successful exercise interventions. Third, evaluation of the exercise-induced neurovascular changes that relate to behavioral improvements, as measured with novel blood supply neuroimaging tools, will advance our knowledge about the brain mechanisms of the observed cognitive benefits. Finally, the validated physical exercise intervention, resulting from this project, will offer a new tool to clinicians seeking to help individuals with aphasia, either as a free-standing program to enhance physical health, cognition, and well-being, or as an adjunct therapy to standard speech-language therapy. Ultimately, this work could significantly alter our thinking about adjuvant aphasia therapies that can benefit those affected by stroke and aphasia through non- traditional means, in this case, a promising, safe, and cost-efficient adjunct intervention that can enhance all levels of functioning from general health to language to social engagement.

项目总结/摘要 失去说话和理解语言的能力对失语症患者及其 家庭，对生活和情感健康的多个方面产生负面影响。不幸的是， 失语症患者很少能完全恢复语言能力。需要新的方法来提高 传统疗法，为失语症患者带来更好的结果。 这项拟议中的研究旨在评估一种有前途的辅助干预措施--体育锻炼的效果。 失语症的康复训练一项新的运动计划，专门为中风后患者设计 失语症，将提供一个安全的，中风和失语症友好的体育锻炼干预的手段， 实现最佳的身体健康收益。这也将是第一个大规模的失语症研究， 检验体育锻炼与传统语言相结合的附加和增强效果 疗法创新的结果测量不仅包括语言和认知测量， 运动技能以及心理和社会心理结果的评估，以评估体育锻炼的益处。 这项研究的另一个前沿方面是包括先进的生理健康措施， 将血流和脑血管反应性的神经影像学指标作为结果指标， 了解运动介导的中风幸存者的行为和神经效应。 我们将招募110名失语症患者，以评估运动对行为的多方面影响。 和身体的结果，并与传统的言语语言治疗相结合。一是 体育锻炼对语言，认知，运动，情绪和心理健康的好处 将建立失语症患者。特别重要的是，要进一步了解 运动可以增强现有的语言治疗的效果。第二，确定运动诱导 身体健康的变化与语言和认知措施的变化有关， 成功的运动干预的关键要素。第三，运动性神经血管损伤的评价 与行为改善有关的变化，如用新的血液供应神经成像工具测量的，将 推进我们对观察到的认知益处的大脑机制的认识。最后，经过验证的 该项目产生的体育锻炼干预将为寻求帮助的临床医生提供一种新工具 失语症患者，无论是作为一个独立的计划，以提高身体健康，认知和福祉， 或作为标准言语-语言治疗的辅助治疗。最终，这项工作可能会大大改变我们的 思考辅助性失语症治疗，可以通过非- 在这种情况下，传统的手段是一种有前途的、安全的、具有成本效益的辅助干预措施， 从一般健康到语言到社会参与的功能水平。