Microbial Impact on NeuroDegeneration in Alzheimer's Dementia: MIND-AD - INCLUDE Admin Suppl

微生物对阿尔茨海默氏痴呆症神经退行性变的影响：MIND-AD - 包括管理补充

• 批准号: 10852264
• 负责人: Brion S Maher
• 金额: $ 37.33万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10852264
• 关键词: 2019-nCoV; Acceleration; Administrative Supplement; Adult; Alzheimer' s Disease; Alzheimer' s disease pathology; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Antibodies; Area; Award; Back; Baltimore; Biological Aging; Biological Markers; Blood; Blood specimen; COVID-19; Catchment Area; Child; Childhood; Clinic; Cognitive; Cytomegalovirus; Data; Databases; Dementia; Diagnosis; Disease; Down Syndrome; Enrollment; Epidemiology; Future; Herpesvirus 1; Human Herpesvirus 2; Human Herpesvirus 4; Impaired cognition; Individual; Infection; Longevity; Measures; Medical; Medical Records; Mental disorders; Mid-Atlantic Region; Mind; Nerve Degeneration; Parents; Participant; Patient Recruitments; Persons; Phenotype; Polysomnography; Prevalence; Prevention; Public Health; Recontacts; Registries; Research; Research Personnel; Sampling; Schools; Sleep; Toxoplasma gondii; Virus; Work; aged; cohort; functional decline; functional outcomes; microbial; mild cognitive impairment; participant enrollment; recruit; social media

Consistent with NOT-OD-22-137, Availability of Administrative Supplements for the INCLUDE Project, we propose to recruit 500 adults with Down syndrome (DS) aged 18-39 in the mid- Atlantic area to create a cohort, per Component 2: “Assembly of a large cohort of individuals with Down syndrome across the lifespan to perform deep phenotyping and study co-existing conditions.” Our Co-Investigator, Dr. Capone, at the Kennedy Krieger Institute (KKI), has data dating back ~25 years on >500 individuals with DS who were then children (3-17yrs) and are now adults. He also has data on an additional ~1,000 who were seen as adults (18-35yr) whom we will recontact for purposes of enrollment. From all 500 participants, we will collect demographic data and next of kin contact information for enrollment in future studies, and we will request releases of medical records from outside of KKI. This registry will be used to enroll participants in a future R01, which, like the parent award (R01AG075996; MPIs Spira & Maher), will investigate the association of antibodies to common infections (HSV- 1, HSV-2, CMV, EBV, TOX, SARS-CoV-2) in blood with cognitive and functional outcomes, mild cognitive impairment (MCI-DS) and dementia diagnoses, blood-based AD biomarkers, and measures of accelerated biological aging in persons with DS. If we cannot recruit 500 participants from among Dr. Capone’s former participants, we will expand through the mid-Atlantic region via mailing lists, clinics, schools, social media, and snowball sampling. We will prioritize recruitment of participants from Dr. Capone’s KKI database with existing data from childhood on medical conditions, psychiatric disorders, cognitive/adaptive function, and sleep data from polysomnography. This work is a supplement to Wave 5.5 of the Baltimore Epidemiologic Catchment Area (ECA) Study, which is investigating associations of common infections with cognitive and functional outcomes, MCI and dementia diagnoses, blood-based AD biomarkers, and measures of accelerated biological aging in that cohort.

符合NOT-OD-22-137，INCLUDE管理补充材料的可用性 项目，我们建议招募500名18-39岁的唐氏综合症（DS）成年人， 根据构成部分2：“集结大批个人”， 与唐氏综合征在整个生命周期进行深入的表型和研究共存 条件”。我们的合作研究员，肯尼迪克里格研究所（KKI）的卡彭博士， 可追溯到约25年前，>500名DS患者，当时他们还是儿童（3- 17岁）， 现在是成年人。他还有另外1,000名成年人（18- 35岁）的数据 我们将重新联系他们进行登记。从所有500名参与者中，我们将 收集人口统计学数据和近亲联系信息用于未来研究的入组， 我们会要求KKI以外的人提供医疗记录该注册表将用于 在未来的R 01中招募参与者，与母公司奖励（R 01 AG 075996; MPI）一样， Spira和Maher），将研究抗体与常见感染（HSV-1）的关系。 1，HSV-2，CMV，EBV，TOX，SARS-CoV-2）与认知和功能结局， 轻度认知功能障碍（MCI-DS）和痴呆诊断，基于血液的AD 生物标志物和DS患者加速生物老化的措施。如果我们 我们无法从卡彭博士以前的参与者中招募500名参与者，我们将扩大 通过邮件列表、诊所、学校、社交媒体和雪球， 取样.我们将优先从卡彭博士的KKI招募参与者 数据库，其中有儿童时期的医疗条件、精神疾病、 认知/适应功能和来自多导睡眠图的睡眠数据。这部作品是一个补充 巴尔的摩流行病学集水区（ECA）研究的第5.5波，该研究正在调查 常见感染与认知和功能结果、MCI和痴呆的关系 诊断，基于血液的AD生物标志物，以及加速生物老化的措施， 队列。