Einstein-Mount Sinai Diabetes Research Center

爱因斯坦西奈山糖尿病研究中心

• 批准号: 10852709
• 负责人: JEFFREY E. PESSIN
• 金额: $ 42.5万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-12-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10852709
• 关键词: Address; Advisory Committees; Affect; Agreement; Award; COVID-19; Center Core Grants; Center for Translational Science Activities; Clinical; Collaborations; Communities; Core Facility; Diabetes Mellitus; Digestive System Disorders; Disease; Fostering; Funding; Funding Mechanisms; Future; Goals; Grant; Individual; Institution; Kidney Diseases; Long COVID; Longevity; Low Income Population; Metabolic; Metabolic Diseases; Metabolism; Obesity; Policies; Population; Principal Investigator; Process; Research; Research Infrastructure; Research Personnel; Research Project Grants; SARS-CoV-2 infection; Technology; Time; Translating; Translational Research; Work; ethnic minority; health disparity; health equity; health inequalities; meetings; metabolic abnormality assessment; minority communities; mortality; novel; programs; racial minority; translational research program; translational study

SUMMARY/ABSTRACT: Due to the high mortality (>2% of infected individuals world-wide) with ~25% of infected individuals developing post-acute COVID-19 syndromes, the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) organized a taskforce composed of Diabetes Research Centers (DRCs) and Centers for Diabetes Translational Research (CDTRs) to explore research directions that should be harnessed to address the issues associated with COVID-19 and metabolism. Two related efforts were broadly agreed upon to be of important current and future value and were endorsed at the Spring NIDDK Council meeting. This application for a Supplement represents our formal request for NIDDK funds to support the second year of a novel research program that will take advantage of the established of the NIDDK funded DRC and CDTR infrastructures. Within this framework, there are two overarching goals. The immediate goal is to foster COVID-19 metabolism research which leverages the existing technologies and strengths that exist with the national DRC and CDTR programs. The long-term goal is to develop a work flow for expanding national research collaborations across the diabetes/obesity and metabolic disease research communities at the basic, clinical, translational, community and health disparity levels. To accomplish these objectives, we propose to continue the second year of funding for the three active awards that we have support in year 01.

摘要/摘要： 由于高死亡率(占全球感染者的2%)，约25%的感染者 急性后新冠肺炎综合征患者，美国国家糖尿病研究所， 消化和肾脏疾病(NIDDK)组织了一个由糖尿病研究组成的特别工作组 糖尿病转化研究中心(DRC)和糖尿病转化研究中心(CDTRs)探索研究 应该利用的方向，以解决与新冠肺炎和 新陈代谢。两项相关的努力被广泛认为具有当前和未来的重要意义。 价值，并在春季NIDDK理事会会议上得到认可。这份申请是一份 附录代表我们对NIDDK基金的正式请求，以支持 新的研究计划将利用NIDDK资助的DRC的建立 和CDTR基础设施。 在这个框架内，有两个首要目标。眼下的目标是培养 新冠肺炎新陈代谢研究，利用现有技术和优势 与国家发改委和发改委方案并存。长期目标是开发一个工作流程 扩大糖尿病/肥胖症和代谢领域的国家研究合作 基础、临床、转化、社区和卫生领域的疾病研究社区 不平等程度。为了实现这些目标，我们建议继续第二年的 为我们在01年支持的三个活跃奖项提供资金。

项目成果

Allostatic load, unhealthy behaviors, and depressive symptoms in the Hispanic Community Health Study/Study of Latinos.

• DOI: 10.1016/j.ssmph.2021.100917
• 发表时间: 2021-12
• 期刊: SSM - population health
• 作者: Rodriquez EJ;Coreas SI;Gallo LC;Isasi CR;Salazar CR;Bandiera FC;Suglia SF;Perreira KM;Hernandez R;Penedo F;Talavera GA;Daviglus ML;Pérez-Stable EJ
• 通讯作者: Pérez-Stable EJ

The multiple faces of RAGE--opportunities for therapeutic intervention in aging and chronic disease.

• DOI: 10.1517/14728222.2016.1111873
• 发表时间: 2016
• 期刊: Expert opinion on therapeutic targets
• 影响因子: 5.8
• 作者: Ramasamy R;Shekhtman A;Schmidt AM
• 通讯作者: Schmidt AM

Comparative analyses of population-scale phenomic data in electronic medical records reveal race-specific disease networks.

• DOI: 10.1093/bioinformatics/btw282
• 发表时间: 2016-06-15
• 期刊: Bioinformatics (Oxford, England)
• 作者: Glicksberg BS;Li L;Badgeley MA;Shameer K;Kosoy R;Beckmann ND;Pho N;Hakenberg J;Ma M;Ayers KL;Hoffman GE;Dan Li S;Schadt EE;Patel CJ;Chen R;Dudley JT
• 通讯作者: Dudley JT

Bmal1 regulates production of larger lipoproteins by modulating cAMP-responsive element-binding protein H and apolipoprotein AIV.

• DOI: 10.1002/hep.32196
• 发表时间: 2022-07
• 期刊: Hepatology (Baltimore, Md.)
• 作者: Pan X;Hussain MM
• 通讯作者: Hussain MM

Mass Spectrometry and Pharmacological Approaches to Measuring Cooption and Reciprocal Activation of Receptor Tyrosine Kinases.

• DOI: 10.3390/proteomes11020020
• 发表时间: 2023-06-02
• 期刊: Proteomes
• 影响因子: 3.3
• 作者: Linzer J;Phelps Z;Vummidi S;Lee BYE;Coant N;Haley JD
• 通讯作者: Haley JD