Diabetes Research and Training Center

这项提议是为了继续资助阿尔伯特糖尿病研究和培训中心(DRTC) 爱因斯坦医学院。该计划的目的是促进与糖尿病相关的生物医学研究。 促进将研究成果转化为改善健康成果，特别是 在服务不足和少数群体中。此应用程序中的资金用于支持行政部门 全面负责管理、整合和促进研究与培训的构成部分 以及一系列生物医学核心，将继续为各种科学家提供服务 与糖尿病相关的研究。我们选择了这些DRTC核心来补充和增加服务 由现有的爱因斯坦机构核心提供。这些核心是：1)动物生理学核心， 将为碳水化合物、脂肪和能量代谢的整体动物研究提供创新的方法 和激素作用，以及2)分析核心，它将提供对底物、酶、 示踪剂和基因表达；3)激素分析核心，它将为研究人员提供分析 胰岛素、胰升糖素、其他多肽等服务；4)基因修饰核心，将有助于 生成用于开发相关动物模型的构造，以及5)细胞和分子信号核心 这将为复杂系统中的信令分析提供帮助。还要求提供资金，以 继续成功的试点和可行性研究计划，通过该计划在基础、临床和 行为研究将得到支持。这项计划将由爱因斯坦共同赞助，将增加5万美元 每年提高这一计划的资金能力。预防和控制(P&C)部分 将扩大行为、健康服务和流行病学研究的基础 有效性核心和临床研究促进核心。多学科的P&C教师将提供 向受资助的研究人员提供服务，并支持社区联盟采取预防和控制疟疾的举措 糖尿病。消除医疗保健差距的计划将是优先事项。DRTC之间的相互作用 CORES强调将生物医学研究转化为预防和控制糖尿病及其 并发症。DRTC活动将通过主动丰富计划进一步整合，该计划服务于所有 DRTC和整个学术界的组成部分。研究培训将继续进行到 美国国立卫生研究院资助的几个项目和其他资源，以培养未来的研究人员。

This proposal is to continue funding of the Diabetes Research and Training Center (DRTC) at the Albert Einstein College of Medicine. The purpose of this program is to foster biomedical research in diabetesrelated areas and to promote the translation of research findings into improved health outcomes, especially in underserved and minority populations. Funding in this application is to support an administrative component with overall responsibility for management, integration and promotion of research and training and a series of biomedical cores that will continue to provide services to various scientists conducting diabetes-related research. These DRTC cores have been selected to complement and add to the services provided by the existing Einstein institutional cores. These cores are: 1) Animal Physiology Core, which will provide innovative methodologies for whole animal studies of carbohydrate, lipid, and energy metabolism and hormone action and 2) Analytical Core, which will provide specialized assays of substrates, enzymes, tracers, and gene expression; 3) the Hormone Assay Core, which will provide investigators with assays of insulin, glucagon, other peptides and other services; 4) Gene Modifications Core, which will assist in generating constructs for developing relevant animal models, and 5) Cellular and Molecular Signaling Core which will provide assistance with analysis of signaling in complex systems. Funding is also requested to continue a successful Pilot and Feasibility study program through which new initiatives in basic, clinical, and behavioral research will be supported. This Program will be co-sponsored by Einstein which will add $50,000 annually to enhance the funding capability of this program. The Prevention and Control (P&C) Component will expand the base of behavioral, health services, and epidemiological research through a Translation & Effectiveness Core and a Clinical Research Facilitation Core. Multidisciplinary P&C faculty will provide services to funded researchers and support to community coalitions for initiatives in prevention and control of diabetes. Programs to eliminate disparities in health care will take priority. The interaction among DRTC cores emphasizes the translation of biomedical research for the prevention and control of diabetes and its complications. DRTC activities will be further integrated by an active Enrichment Program that serves all components of the DRTC and the academic community at large. Research training will continue through several NIH-funded programs and other resources to develop future researchers.