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中文摘要
翻译
今天的初期和早期职业培训生在肾脏,泌尿,血液(KUH)领域需要培训 在由有成就的团队科学研究人员和熟练的、忠诚的导师组成的环境中。 学员必须学习复杂的研究工具,同时完成教学课程, 发展专业发展技能。协调这些努力将有助于扩大影响力大的 这些障碍造成了学生之间持续的不平等, KUH临床医生和研究人员,这一培训计划的直接收益将实现KUH最 我们服务的患者群体培养下一代KUH研究人员需要机构和导师 以协同方式参与研究和培训。我们聚集了KUH研究人员在3领先 北卡罗来纳州(NC)生物医学研究型大学:北卡罗来纳大学教堂山分校,维克森林 大学,和杜克大学,以及从3个历史上黑人学院和大学,北卡罗来纳州农业 和技术州立大学,温斯顿-塞勒姆州立大学和北卡罗来纳州中央大学。这就形成了 NC KUH TRIO(培训,研究,创新,推广或TRIO)U2 C/TL 1研究培训计划。 TRIO培训核心有3个目标:1)提供教学和实践经验, 基础/转化和临床科学研究; 2)进行研究,包括采用新兴的 技术,并建立在跨学科和跨机构的团队科学整个KUH使命; 和3)建立和维护一个学者社区,扩大和维持KUH研究的多样性。 多学科和团队研究技能将在专业发展核心下发展, 临床和转化科学奖(CTSA)。TRIO的互联社区 从高中到早期教师的学者将由网络核心构建和支持。 合格和积极的TRIO导师将在广泛的,高度的 相关KUH科学专业跨越基础/转化,临床和技术领域。新兴 导师将成熟,以确保未来的领导和长寿的计划。TRIO将利用现有的多机构培训基础设施和生物技术,公共卫生,转化科学, 临床研究一个有针对性的强有力和透明的招生过程将促进多样性, 严格的计划评估将允许实时改进,以满足我们KUH学员的需求。的 一体化的TRIO计划将利用跨机构的协同作用,并提供有凝聚力的方案,以培训 多学科和KUH-related研究团队的下一代领导者。
英文摘要
Today’s incipient and early career trainees in Kidney, Urologic, Hematologic (KUH) fields require training within environments richly populated by accomplished team-science researchers and adept, committed mentors. Trainees must learn sophisticated research tools while simultaneously completing didactic coursework and developing professional development skills. Coordinating these efforts will enable scale-up of high-impact practices to remove the daunting academic and social barriers that have caused persistent disparities among KUH clinicians and researchers, and the direct gains of this training program will be realized most by the KUH patient populations we serve. Training the next generation of KUH researchers requires institutions and mentors to synergistically engage in both research and training. We have brought together KUH researchers at 3 leading North Carolina (NC) biomedical research universities: University of North Carolina-Chapel Hill, Wake Forest University, and Duke University, as well as from 3 Historically Black Colleges and Universities, NC Agricultural & Technical State University, Winston-Salem State University and NC Central University. Together, this forms the NC KUH TRIO (Training, Research, Innovation, Outreach, or TRIO) U2C/TL1 Research Training Program. The TRIO Training Core has 3 objectives: 1) provide didactics and hands-on experience in rigorous basic/translational and clinical sciences research; 2) conduct research that includes adoption of emerging technologies and builds on the cross-disciplinary and cross-institutional team science across the KUH mission; and 3) establishes and nourishes a community of scholars that expands and sustains diversity in KUH research. Multidisciplinary and team research skills will be developed under the Professional Development Core in conjunction with Clinical and Translational Science Award (CTSA) programs. A connected community of TRIO scholars, that spans from high school to early faculty, will be built and supported by the Networking Core. Qualified and motivated TRIO mentors will train both pre- and post-doctoral trainees across broad, highly relevant KUH scientific specialties that span basic/translational, clinical, and technology arenas. Emerging mentors will mature to assure future leadership and longevity of the program. TRIO will exploit existing multi-institutional training infrastructures and programs in biotechnology, public health, translational science, and clinical research. A robust and transparent admissions process with targeted recruitment will foster diversity, and rigorous program evaluation will allow real-time improvement in serving the needs of our KUH trainees. The integrated TRIO program will leverage cross-institutional synergies and provide cohesive programming to train the next generation leaders in multidisciplinary and team KUH-relevant research.
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Targeted conditioning to maximize prenatal HSC engraftment for SCD
Using human liver tissue equivalents to optimize AAV-mediated GT and better define age-related clinical risks
Defining the therapeutic efficacy, tolerogenic potential, and genotoxicity of liver-targeted AAV gene therapy for hemophilia A
cGMP Manufacture Of FVIII-Expressing Placental Cells For Hemophilia A
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