Investigating the effects of VNS on central autonomic network and interoception

研究 VNS 对中枢自主网络和内感受的影响

• 批准号: 10893815
• 负责人: Lynn E Eberly
• 金额: $ 39.15万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-23 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10893815
• 关键词: Academia; Advocate; Anatomy; Anxiety Disorders; Autonomic nervous system; Big Data; Budgets; Cardiovascular system; Clinical; Clinical Data; Clinical Research; Clinical Trials Data Monitoring Committees; Communication; Data; Data Set; Development; Devices; Electric Stimulation; Ensure; Epilepsy; Future; Gastrointestinal Diseases; Goals; Human; Human Resources; Immune; Immune system; Implant; Industry; Institution; Interoception; Medical; Mental Depression; Metabolic; Metabolism; Multi-Institutional Clinical Trial; Nerve; Nervous System Physiology; Organ; Outcome; Patients; Physiological; Physiology; Productivity; Protocols documentation; Research; Research Design; Research Personnel; System; Therapeutic; United States National Institutes of Health; Vagus nerve structure; Work; biophysical model; clinical research site; data ecosystem; data modeling; experience; meetings; multidisciplinary; neuroregulation; novel therapeutics; predictive modeling; programs; response; technology research and development; therapeutic development

ABSTRACT The principal source of visceral afferent information to the brain from the body is the vagus nerve. The sympathetic and parasympathetic nervous systems are the main branches of the autonomic nervous system (ANS), and they dynamically control the visceral functions to maintain body homeostasis. A hallmark of the ANS is its ability to react to environmental challenges/stressors in order to properly respond to the metabolic demands of the organism. Cervical vagus nerve stimulation (VNS) is reported to modulate ANS and in particular heart rate variability (HRV) and baroreflexes. Yet the mechanisms by which these are achieved remain unknown. Disentangling the direct VNS effects of efferent modulation versus a centrally mediated modulation via afferent fibers is key. This Supplemental Project will investigate the functional connectivity patterns of interoception and high-order brain regions as measured by cutting-edge brain functional neuroimaging methods. Most importantly, it will study their relationship to spontaneous fluctuations in blood pressure and heart rate. The REVEAL Common Study Protocol (CSP) hypothesizes that any VNS-induced changes in blood pressure will be via stimulation of afferent (sensory) fibers in the vagus nerve. This study is an alternative to test this hypothesis and will provide key mechanistic data that will complement discoveries from the CSP. By acquiring functional brain imaging before and after VNS implant and most critically, in the moment activations in response to VNS, we can ascertain whether this upstream central nervous system modulation is at the midbrain reflexive level or whether it involves higher-order brain regions. Interleaved VNSfMRI will act as a window for in-the-moment direct effects of VNS on brain activity and interoceptive processes. The cutting edge precision functional mapping will reliably map the multimodal networks involved in interoception and allostasis.

摘要 从身体到大脑的内脏传入信息的主要来源是迷走神经。的 交感神经系统和副交感神经系统是自主神经系统的主要分支 (ANS)它们动态地控制内脏功能以维持机体内环境的稳定。ANS的标志 是它对环境挑战/压力源作出反应的能力，以便适当地响应代谢需求 生物体。据报道，颈部迷走神经刺激（VNS）可调节ANS，特别是心率 心率变异性（HRV）和压力反射。然而，实现这些目标的机制仍然未知。 区分传出调制与通过传入的中枢介导调制的直接VNS效应 纤维是关键。这个补充项目将调查内感受的功能连接模式， 高级大脑区域，通过尖端的脑功能神经成像方法测量。最重要的是， 它将研究它们与血压和心率自发波动的关系。共同的启示 研究方案（CSP）假设任何VNS诱导的血压变化将通过刺激 迷走神经中的传入（感觉）纤维。这项研究是一个替代测试这一假设，并将提供 关键的机械数据，将补充从CSP的发现。通过获取脑功能成像， 在VNS植入后，最关键的是，在VNS激活的瞬间，我们可以确定 这种上游中枢神经系统的调节是否在中脑反射水平， 高级大脑区域。交错VNSfMRI将作为一个窗口，在瞬间的VNS的直接影响， 大脑活动和内感受过程。尖端的精确功能映射将可靠地映射 多模态网络参与内感受和变应性。