Investigating the effects of VNS on central autonomic network and interoception

研究 VNS 对中枢自主网络和内感受的影响

• 批准号: 10893815
• 负责人: Lynn E Eberly
• 金额: $ 39.15万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-23 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10893815
• 关键词: Academia; Advocate; Anatomy; Anxiety Disorders; Autonomic nervous system; Big Data; Budgets; Cardiovascular system; Clinical; Clinical Data; Clinical Research; Clinical Trials Data Monitoring Committees; Communication; Data; Data Set; Development; Devices; Electric Stimulation; Ensure; Epilepsy; Future; Gastrointestinal Diseases; Goals; Human; Human Resources; Immune; Immune system; Implant; Industry; Institution; Interoception; Medical; Mental Depression; Metabolic; Metabolism; Multi-Institutional Clinical Trial; Nerve; Nervous System Physiology; Organ; Outcome; Patients; Physiological; Physiology; Productivity; Protocols documentation; Research; Research Design; Research Personnel; System; Therapeutic; United States National Institutes of Health; Vagus nerve structure; Work; biophysical model; clinical research site; data ecosystem; data modeling; experience; meetings; multidisciplinary; neuroregulation; novel therapeutics; predictive modeling; programs; response; technology research and development; therapeutic development

ABSTRACT The principal source of visceral afferent information to the brain from the body is the vagus nerve. The sympathetic and parasympathetic nervous systems are the main branches of the autonomic nervous system (ANS), and they dynamically control the visceral functions to maintain body homeostasis. A hallmark of the ANS is its ability to react to environmental challenges/stressors in order to properly respond to the metabolic demands of the organism. Cervical vagus nerve stimulation (VNS) is reported to modulate ANS and in particular heart rate variability (HRV) and baroreflexes. Yet the mechanisms by which these are achieved remain unknown. Disentangling the direct VNS effects of efferent modulation versus a centrally mediated modulation via afferent fibers is key. This Supplemental Project will investigate the functional connectivity patterns of interoception and high-order brain regions as measured by cutting-edge brain functional neuroimaging methods. Most importantly, it will study their relationship to spontaneous fluctuations in blood pressure and heart rate. The REVEAL Common Study Protocol (CSP) hypothesizes that any VNS-induced changes in blood pressure will be via stimulation of afferent (sensory) fibers in the vagus nerve. This study is an alternative to test this hypothesis and will provide key mechanistic data that will complement discoveries from the CSP. By acquiring functional brain imaging before and after VNS implant and most critically, in the moment activations in response to VNS, we can ascertain whether this upstream central nervous system modulation is at the midbrain reflexive level or whether it involves higher-order brain regions. Interleaved VNSfMRI will act as a window for in-the-moment direct effects of VNS on brain activity and interoceptive processes. The cutting edge precision functional mapping will reliably map the multimodal networks involved in interoception and allostasis.

抽象的 从体内向大脑的内脏传入信息的主要来源是迷走神经。这 交感神经和副交感神经系统是自主神经系统的主要分支 （ANS），然后动态控制内脏功能以保持身体稳态。 ANS的标志 它的能力是应对环境挑战/压力源以适当应对代谢需求的能力 有机体。据报道，宫颈迷走神经刺激（VNS）调节ANS，尤其是心率 变异性（HRV）和降压力。然而，实现这些实现的机制仍然未知。 通过传入，解散传出调制的直接VNS效应与集中介导的调制 纤维是关键。这个补充项目将调查互认为的功能连通性模式和 高阶大脑区域通过尖端的大脑功能性神经影像学方法测量。最重要的是， 它将研究他们与血压和心率自发波动的关系。揭示的共同点 研究方案（CSP）假设任何VNS诱导的血压变化都将是通过刺激 迷走神经中的传入（感觉）纤维。这项研究是检验该假设的替代方法，并将提供 关键机械数据将补充CSP的发现。通过在之前获取功能性脑成像 在VNS植入和最批判性之后，在响应VN的瞬间激活，我们可以确定 这种上游中央神经系统的调节是否处于中脑反身水平，还是涉及 高阶大脑区域。交错的VNSFMRI将充当VNS内直接影响的窗口 大脑活动和感知过程。最先进的精度功能映射将可靠地映射 涉及的多模式网络参与了Intersoception和Allostasis。