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UMN Udall Biostatistics Core

UMN Udall Biostatistics Core
UMN Udall 生物统计学核心
批准号:
10489827
负责人:
Lynn E Eberly
金额:
$19.37万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
未结题
起止时间:
2021-09-17 至 2026-07-31

项目摘要

项目成果

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中文摘要
翻译
摘要 生物统计核心将在以下方面提供高质量、高效、集成的协作和支持 建议UMN Udall深部脑刺激中心(DBS)治疗帕金森氏病(PD)。整体而言 该中心的主题是开发基于电路的新型脑深部刺激(DBS)疗法 帕金森氏病(PD)。作为所有四个拟议项目的基础,并与其他 核心支持这个基础,这个核心将提供:具有适当广度和深度的人员 正在收集的运动、神经生理、认知和智能手机/远程医疗数据的专业知识; 在研究设计、健壮和可重现的数据管理和质量控制管道方面的服务, 统计和机器学习分析、解释和交流;数据整合 与NINDS帕金森氏病生物标记物收集和共享多种类型的数据 计划(PDBP)数据管理资源(DMR);与熟练掌握有关的职业发展 统计和机器学习方法,研究设计概念,并就 研究人员、博士后和中心学生的纪律小组;参与参与 和传播活动;以及所需的其他资源。我们将密切和广泛地与 关于科学和管理服务的行政核心、临床核心和成像核心 每个项目都在进行中;关于所有核心服务彼此之间的无缝集成 支持项目;根据项目需求确定本核心工作的优先顺序; 中心调查人员和受训人员的持续职业发展;以及支持未来的研究和 在这个拟议中心的推动下,为PD的星展银行战略提供资金机会。此核心的 在研究计划和实施过程中,人员将通过研究与项目团队一起参与 传播,并作为新的跨项目倡议的一部分,这些倡议将整合项目以提供 对帕金森病运动和非运动体征的病理生理学基础的创新见解。此核心的 参与的连续性将提供项目之间的共同联系和持续的互动 与其他核心一起工作。最后,我们将提供资源,用于进一步的探索性分析。 随着研究的进展,充分利用中心精心收集和管理的数据, 从而也促进了未来研究的创新假设的发展。
英文摘要
ABSTRACT The Biostatistics Core will provide high quality, efficient, integrated collaboration in and support of the proposed UMN Udall Center on Deep Brain Stimulation (DBS) for Parkinson’s Disease (PD). The overall theme of the Center is to develop novel, circuit based deep brain stimulation (DBS) therapies for Parkinson’s Disease (PD). As a foundation for all four proposed projects, and in collaboration with other cores in support of this foundation, this Core will provide: personnel with the appropriate breadth and depth of expertise for the motor, neurophysiological, cognitive, and smartphone/telemedicine data being collected; services in study design, robust and reproducible data management and quality control pipelines, statistical and machine learning analysis, and interpretation and communication; data integration across the many types of data being collected and data sharing with the NINDS Parkinson’s Disease Biomarkers Program (PDBP) Data Management Resource (DMR); career development related to proficiency in statistical and machine learning approaches, study design concepts, and communication on inter- disciplinary teams for investigators, post-docs, and students in the Center; participation in engagement and dissemination activities; and other resources as needed. We will interact closely and extensively with the Administrative Core, the Clinical Core, and the Imaging Core on scientific and management services for each project as it is carried out; on the seamless integration of all cores’ services with each other to best support the projects; on the prioritization of this Core’s work across the needs of the projects; on the ongoing career development of Center investigators and trainees; and on supporting future research and funding opportunities on DBS strategies in PD which are motivated by this proposed Center. This Core’s personnel will participate with project teams during study planning and execution, through study dissemination, and as part of novel cross-project initiatives that will integrate the projects to provide innovative insight into the pathophysiological basis of motor and non-motor signs in PD. This Core’s continuity of involvement will provide a common connection among the projects and continuous interaction with the other cores. Lastly, we will provide resources for additional exploratory analyses that come to light as the research progresses, taking full advantage of the Center’s careful data collection and management, thereby also facilitating the development of innovative hypotheses for future research.
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会议论文
REVEAL - Research Evaluating Vagal Excitation and Anatomical Linkages.
  • 批准号:
    10709632
  • 项目类别:
  • 资助金额:
    $717.9万
  • 财政年份:
    2022
  • 负责人:
    Lynn E Eberly
  • 依托单位:
REVEAL - Research Evaluating Vagal Excitation and Anatomical Linkages.
  • 批准号:
    10610556
  • 项目类别:
  • 资助金额:
    $699.7万
  • 财政年份:
    2022
  • 负责人:
    Lynn E Eberly
  • 依托单位:
Investigating the effects of VNS on central autonomic network and interoception
  • 批准号:
    10893815
  • 项目类别:
  • 资助金额:
    $39.15万
  • 财政年份:
    2022
  • 负责人:
    Lynn E Eberly
  • 依托单位:
海外基金