DIET, CELL PROLIFERATION AND BREAST CANCER IN SHANGHAI

上海的饮食、细胞增殖和乳腺癌

• 批准号: 2384990
• 负责人: David D Thomas
• 金额: $ 55.28万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2001-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2384990
• 关键词: antioxidants; blood chemistry; breast neoplasms; cell proliferation; clinical research; diet; disease /disorder proneness /risk; estrogen analog; histology; human subject; immunocytochemistry; interview; mammary gland; neoplasm /cancer classification /staging; neoplasm /cancer epidemiology; nutrition related neoplasm /cancer; nutrition related tag; plant extracts; women's health

DESCRIPTION: The assumption on which this application is based is that factors that enhance mammary cell proliferation act to promote the development of breast cancer, and factors that inhibit proliferation serve as anti-promoters. Several dietary factors have been posited to influence mammary epithelial cell proliferation. The overall goals of the proposed study are to identify associations between various dietary factors and proliferation, as demonstrated histologically and by direct tissue assays, in benign fibrocystic breast lesions and in the mammary epithelium adjacent to both benign and malignant breast tumors. There are also plans to compare dietary factors in women with malignant and proliferative benign breast lesions, accounting for histologic evidence of proliferative changes in the surrounding non-tumorous tissue. Study subjects will be selected from among over 267,000 female textile workers in Shanghai, who were enrolled in 1988-89 in a randomized trial of breast self-examination (BSE). Women in this cohort, who, during a 5-year period, develop breast cancer or fibrocystic lesions, and normal age-matched controls selected from the cohort, will be interviewed to obtain information on risk factors for breast cancer, frequency of intake of multiple foods, recent dietary changes and recent intake of phytoestrogen-rich foods. All data will be gathered prior to diagnosis. Blood specimens will be collected and assayed for various lipids, antioxidant vitamins, and isoflavones. Histologic slides from all cases will be collected, the lesions will be classified, and both the benign lesions and normal tissue will be evaluated for various morphologic and immunocytochemical indicators of ductal and lobular proliferation. Unlike prior studies, consumption of foods in this study sample covers a range over which not only breast cancer rates are expected to vary widely, but also phytoestrogen consumption is high, providing an opportunity to evaluate their role in breast cancer. Also unlike prior epidemiologic studies of diet and breast cancer, in the proposed investigation the primary end points are various indices of cell proliferation.

描述：本申请所基于的假设是， 促进乳腺细胞增殖的因素可以促进 乳腺癌的发展，以及抑制增殖的因素， 作为反推动者。 几种饮食因素已经被假定影响 乳腺上皮细胞增殖 拟议的总体目标 研究是为了确定各种饮食因素之间的联系， 增殖，如组织学和直接组织测定所示， 在良性纤维囊性乳腺病变和乳腺上皮中， 良性和恶性的乳腺肿瘤。 也有计划比较 乳腺癌和增生性良性病变妇女的饮食因素 病变，占增生性变化的组织学证据， 周围的非肿瘤组织。 研究受试者将从以下人员中选择： 上海纺织女工26.7万多人参加了 1988年至1989年，在一项乳房自我检查（BSE）的随机试验中。 妇女 这个队列，谁，在5年期间，发展乳腺癌或 纤维囊性病变，和正常年龄匹配的对照组选自 队列，将接受采访，以获得有关乳腺癌风险因素的信息 癌症，多种食物的摄入频率，最近的饮食变化， 最近摄入植物雌激素丰富的食物。 所有数据将在 诊断。 将采集血液样本并进行各种检测 脂质、抗氧化维生素和胆甾酮。 所有组织切片 将收集病例，对病变进行分类， 将对病变和正常组织的各种形态学和 导管和小叶增生的免疫细胞化学指标。 不像 在先前的研究中，本研究样本中的食物消费量涵盖了 不仅乳腺癌的发病率预计会有很大的差异， 植物雌激素的消耗量很高， 在乳腺癌中的作用 也不像以前的流行病学研究， 饮食和乳腺癌，在拟议的研究的主要终点 是细胞增殖的各种指数。