INCIDENCE OF HIV INFECTIONS IN A COHORT OF IV DRUG USERS

描述：(申请人摘要) 这项研究的目的是确定时间趋势和风险因素。 对于目前艾滋病毒呈阴性的注射吸毒者感染艾滋病毒的新情况 但仍处于高风险状态。这将通过跟踪1000人的队列来完成 HIV阴性吸毒者，每隔6个月，连续3年。这项研究将 允许评估与行为改变相关的因素 在这个高危人群中度过的时光。它还将允许对 药物治疗、针灸等干预措施的现场效果 交换、针头消毒和教育计划，以降低高风险 年吸毒人群预防HIV感染的行为 巴尔的摩目前每年有4%的人感染艾滋病毒。在……里面 此外，还将评估这一人群的发病率和死亡率。 与艾滋病毒阳性人群在同一时期的跟踪调查相比 诊所。这将允许评估这一人群中的哪些疾病 都与艾滋病毒有关。艾滋病病毒与其他常见感染之间的相互作用 这一队列，如乙肝和丙型肝炎、结核病、HTLV-II和 将对肺炎球菌进行评估。这项研究将使我们能够确定 艾滋病毒血清转换者在感染后不久。详细病毒学 最近的HIV血清转换者的免疫学研究将允许 更好地了解艾滋病病毒感染的早期自然历史 人口，以便设计干预策略，以防止快速 进展为艾滋病。 美国吸毒者中艾滋病病例的比例和他们的 儿童和性接触者越来越多。年艾滋病疫情的控制 美国需要更好地了解当前的发病率 以及在这一关键人群中感染艾滋病毒的风险因素。

DESCRIPTION: (Applicant's Abstract) The purposes of this study are to identify temporal trends and risk factors for new HIV infection in injecting drug users who are currently HIV negative but remain at high risk. This will be done by following a cohort of 1,000 HIV negative drug users at six month intervals for 3 years. This study will allow the evaluation of the factors associated with behavior change over time in this high risk population. It will also allow an evaluation of the field effectiveness of such interventions as drug treatment, needle exchange, needle disinfection and educational programs to reduce high risk behavior in order to prevent HIV infection in a population of drug users in Baltimore, who currently have a 4% annual incidence of HIV infection. In addition, morbidity and mortality rates in this population will be assessed and compared with an HIV-positive population being followed in the same clinic. This will allow evaluation of which illnesses in this population are HIV-related. The interaction between HIV and other common infections in this cohort, such as hepatitis B and C, tuberculosis, HTLV-II and pneumococci will be evaluated. This study will allow the identification of HIV seroconverters soon after they become infected. Detailed virological and immunological studies among recent HIV seroconverters will allow a better understanding of the early natural history of HIV infections in this population, in order to design intervention strategies to prevent rapid progression to AIDS. The proportion of AIDS cases in the United States among drug users and their children and sexual contacts is increasing. Control of the AIDS epidemic in the United States requires a better understanding of the current incidence and risk factors for HIV infection in this critical population.