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PRODRUGS AND AQUEOUS FORMULATIONS OF DEXANABINOL

PRODRUGS AND AQUEOUS FORMULATIONS OF DEXANABINOL
地塞米诺的前药和水性制剂
批准号：
2038382
负责人：
Emil Pop
金额：
$10.0万
依托单位：
PHARMOS CORPORATION
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-05-01 至 1997-10-31
来源：
https://reporter.nih.gov/project-details/2038382
关键词：
NMDA receptors cannabinoids chemical stability chemical synthesis chromatography cyclodextrins drug design /synthesis /production drug screening /evaluation human tissue inhibitor /antagonist laboratory rat neuroprotectants prodrugs water solubility

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中文摘要
翻译
描述：（改编自申请人摘要）该提案侧重于
英文摘要
DESCRIPTION: (adapted from applicant's abstract) The proposal focuses on the design and synthesis of prodrugs of the NMDA antagonist dexanabinol (HU 211). This compound demonstrates efficacy as an antiischemic agent but may have limited therapeutic potential due to its low water solubility. The objective of the proposal is therefore to derivatize the parent compound with various esters of amino acids containing quaternary or tertiary amines and evaluate them for water and blood stability. Promising candidates will be evaluated for toxicity. Phase II studies will further develop and evaluate prodrug candidates as potential treatment for brain injury.
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Synthesis of non-GMP Small Molecules
Synthesis of non-GMP Small Molecules
SYNTHESIS OF NON-GMP SMALL MOLECULES
  • 批准号：
    7542178
  • 项目类别：
  • 资助金额：
    $12.5万
  • 财政年份：
    2006
  • 负责人：
    Emil Pop
  • 依托单位：
    --
ARRA-Synthesis of non-GMP Small Molecules
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