RIBOZYME MEDIATED GENE THERAPY FOR ORAL CANCER
RIBOZYME MEDIATED GENE THERAPY FOR ORAL CANCER
批准号:
2414708
负责人:
ZHUO Georgia CHEN
金额:
$3.75万
依托单位国家:
美国
项目类别:
财政年份:
1996
资助国家:
美国
项目状态:
已结题
起止时间:
1996-05-01 至 1998-04-30
关键词:
cell growth regulation enzyme activity enzyme inhibitors enzyme structure epidermal growth factor gene expression gene induction /repression gene therapy growth factor receptors immunoprecipitation membrane proteins messenger RNA neoplastic cell neoplastic growth oral pharyngeal neoplasm phenotype polymerase chain reaction protein kinase protein sequence receptor expression ribonuclease III ribozymes tissue /cell culture transfection /expression vector western blottings
中文摘要
点击翻译按钮获取中文摘要
英文摘要
DESCRIPTION: This application proposes to test the hypothesis that
reduction of oral tumor cell EGF receptor mRNA can lead to inhibition of
tumor cell growth. There are two specific aims proposed to test the stated
hypothesis. Aim 1 proposes to construct an inducible and stable vector for
ribozyme expression. Aim 2 proposes to test ribozyme inhibition of EGFR
expression at the RNA and protein levels and to test their effects on the
transformed phenotype of oral cancer cells which overexpress EGFR.
期刊论文(1)
专著(0)
科研奖励(0)
会议论文
Correlation of cisplatin sensitivity with differential alteration of EGFR expression in head and neck cancer cells.
顺铂敏感性与头颈癌细胞中 EGFR 表达差异变化的相关性。
DOI:
--
发表时间:
2000
期刊:
Anticancer research.
影响因子:
--
作者:
[Chen,Z, Ke,LD, Yuan,XH, Adler-Storthz,K]
通讯作者:
Adler-Storthz,K
A Novel genomics-based approach to differentiate HPV-positive and -negative HNC
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批准号:8772461
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项目类别:
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资助金额:$20.36万
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财政年份:2014
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负责人:ZHUO Georgia CHEN
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依托单位:
Developing a Platform for Prediction of Metastasis Using Multiplexed QD-imaging
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批准号:8504823
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项目类别:
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资助金额:$29.7万
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财政年份:2011
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负责人:ZHUO Georgia CHEN
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依托单位:
Developing a Platform for Prediction of Metastasis Using Multiplexed QD-imaging
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批准号:8177540
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项目类别:
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资助金额:$30.82万
-
财政年份:2011
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负责人:ZHUO Georgia CHEN
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依托单位:
Developing a Platform for Prediction of Metastasis Using Multiplexed QD-imaging
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批准号:8307808
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项目类别:
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资助金额:$35.48万
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财政年份:2011
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负责人:ZHUO Georgia CHEN
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依托单位:
Identifying High Risk Cells in Primary SCCHN to Predict Lymph Node Metastasis
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批准号:7473094
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项目类别:
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资助金额:$17.43万
-
财政年份:2008
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负责人:ZHUO Georgia CHEN
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依托单位:
Identifying High Risk Cells in Primary SCCHN to Predict Lymph Node Metastasis
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批准号:7669280
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项目类别:
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资助金额:$20.93万
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财政年份:2008
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负责人:ZHUO Georgia CHEN
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依托单位:
Identification of Metastasis-related Gene in Oral Cancer
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批准号:6534702
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项目类别:
-
资助金额:$6.7万
-
财政年份:2003
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负责人:ZHUO Georgia CHEN
-
依托单位:
Identification of Metastasis-related Gene in Oral Cancer
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批准号:6900202
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项目类别:
-
资助金额:$8.42万
-
财政年份:2003
-
负责人:ZHUO Georgia CHEN
-
依托单位:
Identification of Metastasis-related Gene in Oral Cancer
-
批准号:6787731
-
项目类别:
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资助金额:$15.3万
-
财政年份:2003
-
负责人:ZHUO Georgia CHEN
-
依托单位:
REGULATION OF HUMAN PAPILLOMAVIRUSES IN ORAL MUCOSA
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批准号:6176049
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项目类别:
-
资助金额:$6.29万
-
财政年份:1998
-
负责人:ZHUO Georgia CHEN
-
依托单位:
REGULATION OF HUMAN PAPILLOMAVIRUSES IN ORAL MUCOSA
-
批准号:2849594
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项目类别:
-
资助金额:$5.26万
-
财政年份:1998
-
负责人:ZHUO Georgia CHEN
-
依托单位:
REGULATION OF HUMAN PAPILLOMAVIRUSES IN ORAL MUCOSA
-
批准号:2896905
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项目类别:
-
资助金额:$6.1万
-
财政年份:1998
-
负责人:ZHUO Georgia CHEN
-
依托单位:
REGULATION OF HUMAN PAPILLOMAVIRUSES IN ORAL MUCOSA
-
批准号:6598812
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项目类别:
-
资助金额:$3.75万
-
财政年份:1998
-
负责人:ZHUO Georgia CHEN
-
依托单位:
REGULATION OF HUMAN PAPILLOMAVIRUSES IN ORAL MUCOSA
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批准号:6379686
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项目类别:
-
资助金额:$2.73万
-
财政年份:1998
-
负责人:ZHUO Georgia CHEN
-
依托单位:
REGULATION OF HUMAN PAPILLOMAVIRUSES IN ORAL MUCOSA
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批准号:6523808
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项目类别:
-
资助金额:$6.67万
-
财政年份:1998
-
负责人:ZHUO Georgia CHEN
-
依托单位:
REGULATION OF HUMAN PAPILLOMAVIRUSES IN ORAL MUCOSA
-
批准号:2733299
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项目类别:
-
资助金额:$10.48万
-
财政年份:1996
-
负责人:ZHUO Georgia CHEN
-
依托单位:
REGULATION OF HUMAN PAPILLOMAVIRUSES IN ORAL MUCOSA
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批准号:2443318
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项目类别:
-
资助金额:$9.98万
-
财政年份:1996
-
负责人:ZHUO Georgia CHEN
-
依托单位:
REGULATION OF HUMAN PAPILLOMAVIRUSES IN ORAL MUCOSA
-
批准号:6172923
-
项目类别:
-
资助金额:$11.33万
-
财政年份:1996
-
负责人:ZHUO Georgia CHEN
-
依托单位:
REGULATION OF HUMAN PAPILLOMAVIRUSES IN ORAL MUCOSA
-
批准号:2115687
-
项目类别:
-
资助金额:$9.84万
-
财政年份:1996
-
负责人:ZHUO Georgia CHEN
-
依托单位:
REGULATION OF HUMAN PAPILLOMAVIRUSES IN ORAL MUCOSA
-
批准号:2895735
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项目类别:
-
资助金额:$10.9万
-
财政年份:1996
-
负责人:ZHUO Georgia CHEN
-
依托单位:
海外基金