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RIBOZYME MEDIATED GENE THERAPY FOR ORAL CANCER

RIBOZYME MEDIATED GENE THERAPY FOR ORAL CANCER
核酶介导的口腔癌基因治疗
批准号:
2414708
负责人:
ZHUO Georgia CHEN
金额:
$3.75万
依托单位国家:
美国
项目类别:
财政年份:
1996
资助国家:
美国
项目状态:
已结题
起止时间:
1996-05-01 至 1998-04-30

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中文摘要
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英文摘要
DESCRIPTION: This application proposes to test the hypothesis that reduction of oral tumor cell EGF receptor mRNA can lead to inhibition of tumor cell growth. There are two specific aims proposed to test the stated hypothesis. Aim 1 proposes to construct an inducible and stable vector for ribozyme expression. Aim 2 proposes to test ribozyme inhibition of EGFR expression at the RNA and protein levels and to test their effects on the transformed phenotype of oral cancer cells which overexpress EGFR.
期刊论文(1)
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会议论文
Correlation of cisplatin sensitivity with differential alteration of EGFR expression in head and neck cancer cells.
顺铂敏感性与头颈癌细胞中 EGFR 表达差异变化的相关性。
DOI: --
发表时间: 2000
期刊: Anticancer research.
影响因子: --
作者: [Chen,Z, Ke,LD, Yuan,XH, Adler-Storthz,K]
通讯作者: Adler-Storthz,K
A Novel genomics-based approach to differentiate HPV-positive and -negative HNC
  • 批准号:
    8772461
  • 项目类别:
  • 资助金额:
    $20.36万
  • 财政年份:
    2014
  • 负责人:
    ZHUO Georgia CHEN
  • 依托单位:
Developing a Platform for Prediction of Metastasis Using Multiplexed QD-imaging
  • 批准号:
    8504823
  • 项目类别:
  • 资助金额:
    $29.7万
  • 财政年份:
    2011
  • 负责人:
    ZHUO Georgia CHEN
  • 依托单位:
Developing a Platform for Prediction of Metastasis Using Multiplexed QD-imaging
  • 批准号:
    8177540
  • 项目类别:
  • 资助金额:
    $30.82万
  • 财政年份:
    2011
  • 负责人:
    ZHUO Georgia CHEN
  • 依托单位:
Developing a Platform for Prediction of Metastasis Using Multiplexed QD-imaging
  • 批准号:
    8307808
  • 项目类别:
  • 资助金额:
    $35.48万
  • 财政年份:
    2011
  • 负责人:
    ZHUO Georgia CHEN
  • 依托单位:
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