SELECTIVE ATTENTION ASYMMETRIES IN SCHIZOPHRENIA

精神分裂症的选择性注意力不对称

• 批准号: 2392960
• 负责人: Joseph I. Tracy
• 金额: $ 6.26万
• 依托单位: ALLEGHENY UNIVERSITY OF HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-04-01 至 1998-11-10
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2392960
• 关键词: attention; cerebral dominance; clinical research; human subject; neural information processing; neuropsychological tests; neuropsychology; prognosis; psychopharmacology; schizophrenia; visual perception

A recent study of selective attention operations in schizophrenia reported subtle right visual field (RVF) hemineglect in a sample of non- chronic schizophrenics (Posner et al, 1988). This finding stimulated speculation about specific lateralized lesions (left parietal and/or left anterior) and attentional operations (i.e., diminished left hemisphere ability to generate preparatory sets) in schizophrenia. These findings were also used to explain other attention abnormalities in schizophrenia (i.e., vigilance). Replication of this important finding is needed to ensure that model building activity in selective attention is on solid ground. Also, determination of the mechanism underlying the finding is needed for accurate neuroanatomical theory and further research on its diagnostic or etiologic value. Specifically, the hemineglect may be caused by a failure in stimulus selection, i.e., filtering, or an inability to generate attentional gradients, which play a key role in generating preparatory, expectational sets. Finally, the temporal stability of deficits in selective attention have not been established and their relation to neuroleptic medication and clinical state have yet to be defined. This project will replicate the Posner et al. (1988) study and assess performance on a shape identification, i.e., filtering, task (LaBerge and Brown, 1989) through a four group, repeated measures design (N=120; baseline, 3 and 6 month assessments). Chronic schizophrenics on one of three neuroleptic regimens (clozapine, risperidone, prolixin decanoate, n's=30) and normal controls (n=30) will be followed for six months. Patients will remain on the same neuroleptic throughout the study. Serial assessments will also be taken of psychiatric symptoms, cognitive status, and gross hemineglect. The three schizophrenic groups will be matched on duration of illness. All four groups will be matched on age and gender. The hemineglect hypothesis will be tested along with tests of an early filtering mechanism for visual shape, and the ability to generate attentional gradients.

对精神分裂症的选择性注意操作的最新研究 据报道，在非 - 慢性精神分裂症患者（Posner等，1988）。 这一发现刺激了 关于特定侧向病变的猜测（左顶和/或左侧 前部）和注意操作（即左半球减小 在精神分裂症中产生预备集的能力。 这些发现 也被用来解释精神分裂症的其他注意力异常 （即警惕）。需要复制这一重要发现 确保选择性关注的模型构建活动是在固体上 地面。 同样，确定该发现的机制是 需要进行准确的神经解剖学理论，并进一步研究其 诊断或病因。 具体而言，倾斜可能是 由刺激选择失败引起的，即过滤或 无法产生注意力梯度，这在 产生预期的预期集。 最后，时间 尚未确定缺陷的稳定性 它们与神经蛋白质药物和临床状态的关系尚未 定义。 该项目将复制Posner等人。 （1988）研究和评估 形状识别的性能，即过滤，任务（Laberge和 Brown，1989）通过四组重复测量设计（n = 120； 基线，3个月和6个月评估）。 慢性精神分裂症 三种神经诱导的方案（氯氮平，利培酮，prolixin decanoate， n = 30）和正常对照（n = 30）将持续六个月。 在整个研究中，患者将保持相同的神经疗法。 连续评估还将对精神病症状，认知症状进行 状态和倾斜度。 这三个精神分裂者将是 与疾病的持续时间相匹配。 所有四个小组都将在年龄上匹配 和性别。 Hemineglect假设将与测试一起测试 早期过滤机制的视觉形状，以及能够 产生注意力梯度。