SELECTIVE ATTENTION ASYMMETRIES IN SCHIZOPHRENIA

精神分裂症选择性注意手术的近期研究 报告了一例细微的右视野(RVF)偏瘫 慢性精神分裂症患者(波斯纳等人，1988年)。这一发现刺激了 推测特定的偏侧病变(左侧顶叶和/或左侧 前部)和注意力手术(即缩小的左半球 产生预备组的能力)。这些发现 也被用来解释精神分裂症的其他注意力异常 (即警觉)。复制这一重要发现是必要的 确保选择性注意中的模型构建活动处于实心状态 地面。此外，对这一发现背后的机制的确定是 准确的神经解剖学理论及其进一步研究所需 诊断或病因学价值。具体地说，半身不指可能是 由刺激选择失败引起的，即过滤，或 无法产生注意力梯度，这在 产生预备性的、期待性的套装。最后，时间上的 选择性注意缺陷的稳定性尚未建立 以及它们与抗精神病药和临床状态的关系 待定。 该项目将复制波斯纳等人的研究成果。(1988)学习评估 形状识别的性能，即过滤、任务(LaBerge和 Brown，1989)通过四组重复测量设计(N=120； 基线、3个月和6个月评估)。慢性精神分裂症患者服用其中一种 三种抗精神病药物(氯氮平、利培酮、普罗利新、 N=30)和正常对照组(n=30)进行为期6个月的随访。 在整个研究过程中，患者将继续服用相同的抗精神病药物。 还将对精神症状、认知能力进行一系列评估 身份和粗略的半身不熟。这三个精神分裂症小组将是 与病程相匹配。这四组人的年龄都是匹配的 和性别。半封闭假说将与测试一起被检验。 视觉形状的早期过滤机制，以及 产生注意力梯度。

A recent study of selective attention operations in schizophrenia reported subtle right visual field (RVF) hemineglect in a sample of non- chronic schizophrenics (Posner et al, 1988). This finding stimulated speculation about specific lateralized lesions (left parietal and/or left anterior) and attentional operations (i.e., diminished left hemisphere ability to generate preparatory sets) in schizophrenia. These findings were also used to explain other attention abnormalities in schizophrenia (i.e., vigilance). Replication of this important finding is needed to ensure that model building activity in selective attention is on solid ground. Also, determination of the mechanism underlying the finding is needed for accurate neuroanatomical theory and further research on its diagnostic or etiologic value. Specifically, the hemineglect may be caused by a failure in stimulus selection, i.e., filtering, or an inability to generate attentional gradients, which play a key role in generating preparatory, expectational sets. Finally, the temporal stability of deficits in selective attention have not been established and their relation to neuroleptic medication and clinical state have yet to be defined. This project will replicate the Posner et al. (1988) study and assess performance on a shape identification, i.e., filtering, task (LaBerge and Brown, 1989) through a four group, repeated measures design (N=120; baseline, 3 and 6 month assessments). Chronic schizophrenics on one of three neuroleptic regimens (clozapine, risperidone, prolixin decanoate, n's=30) and normal controls (n=30) will be followed for six months. Patients will remain on the same neuroleptic throughout the study. Serial assessments will also be taken of psychiatric symptoms, cognitive status, and gross hemineglect. The three schizophrenic groups will be matched on duration of illness. All four groups will be matched on age and gender. The hemineglect hypothesis will be tested along with tests of an early filtering mechanism for visual shape, and the ability to generate attentional gradients.