SELECTIVE ATTENTION ASYMMETRIES IN SCHIZOPHRENIA

精神分裂症选择性注意操作的研究进展 在一个样本中报告了轻微的右视野（RVF）偏侧， 慢性精神分裂症（Posner等，1988）。 这一发现刺激了 推测特定的偏侧病变（左顶叶和/或左 前部）和注意力操作（即，左半球缩小 产生预备集的能力）。 这些发现 也被用来解释精神分裂症的其他注意力异常 (i.e.,警惕）。需要复制这一重要发现， 确保重点示范创建活动扎实开展 地上 此外，确定该发现背后的机制是 需要准确的神经解剖学理论和进一步的研究， 诊断或病因学价值。 具体地，所述半胱氨酸可以是 由刺激选择失败引起，即，过滤，或 无法产生注意力梯度，这在 产生预备的预期的集合。 最后，时间 选择性注意缺陷的稳定性尚未确定 以及它们与精神抑制药物和临床状态的关系， 待定义。 该项目将复制Posner等人（1988年）的研究，并评估 在形状识别上的性能，即，过滤，任务（LaBerge和 Brown，1989）通过四组重复测量设计（N=120; 基线、3个月和6个月评估）。 慢性精神分裂症患者 三种抗精神病药物方案（氯氮平，利培酮，癸酸普利辛， n =30）和正常对照组（n=30）将随访6个月。 在整个研究期间，患者将继续使用相同的精神抑制剂。 还将对精神症状、认知能力、 状态和严重偏侧肌力异常 三组精神分裂症患者 与患病时间相匹配。 所有四组都将在年龄上匹配 和性别。 将沿着检验偏侧肌力假设 视觉形状的早期过滤机制，以及 产生注意力梯度。

A recent study of selective attention operations in schizophrenia reported subtle right visual field (RVF) hemineglect in a sample of non- chronic schizophrenics (Posner et al, 1988). This finding stimulated speculation about specific lateralized lesions (left parietal and/or left anterior) and attentional operations (i.e., diminished left hemisphere ability to generate preparatory sets) in schizophrenia. These findings were also used to explain other attention abnormalities in schizophrenia (i.e., vigilance). Replication of this important finding is needed to ensure that model building activity in selective attention is on solid ground. Also, determination of the mechanism underlying the finding is needed for accurate neuroanatomical theory and further research on its diagnostic or etiologic value. Specifically, the hemineglect may be caused by a failure in stimulus selection, i.e., filtering, or an inability to generate attentional gradients, which play a key role in generating preparatory, expectational sets. Finally, the temporal stability of deficits in selective attention have not been established and their relation to neuroleptic medication and clinical state have yet to be defined. This project will replicate the Posner et al. (1988) study and assess performance on a shape identification, i.e., filtering, task (LaBerge and Brown, 1989) through a four group, repeated measures design (N=120; baseline, 3 and 6 month assessments). Chronic schizophrenics on one of three neuroleptic regimens (clozapine, risperidone, prolixin decanoate, n's=30) and normal controls (n=30) will be followed for six months. Patients will remain on the same neuroleptic throughout the study. Serial assessments will also be taken of psychiatric symptoms, cognitive status, and gross hemineglect. The three schizophrenic groups will be matched on duration of illness. All four groups will be matched on age and gender. The hemineglect hypothesis will be tested along with tests of an early filtering mechanism for visual shape, and the ability to generate attentional gradients.