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Short silk nanofibre based 3D scaffolds with enhanced biomimicry

Short silk nanofibre based 3D scaffolds with enhanced biomimicry
具有增强仿生性的基于短丝纳米纤维的 3D 支架
批准号:
LP140100287
负责人:
Prof Xungai Wang
金额:
$33.16万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Linkage Projects
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-02-16 至 2018-12-31

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中文摘要
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英文摘要
This project aims to understand the behaviour of haematopoietic stem cells (HSC) in novel 3D scaffolds based on short silk nanofibres. This will lead to highly functional 3D scaffolding materials that support efficient HSC renewal in vitro. This project aims to overcome the key problem with existing in vitro systems, which lack the morphological and biochemical complexities of native HSC-niche. Since haematopoietic stem cells are the precursors to all blood cells, this project has the potential of engineering a high yield artificial ‘blood factory’, which will help save the lives of many thousands of people who rely on bone marrow transplants to treat life-threatening illness such as leukaemia.
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