TEXAS CANCER GENETICS CONSORTIUM

德克萨斯州癌症遗传学联盟

• 批准号: 6804311
• 负责人: LOUISE C STRONG
• 金额: $ 121.78万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6804311
• 关键词: TEXAS; CANCER; GENETICS; CONSORTIUM

We propose a Texas Cancer Genetics Consortium (TCGC) in response to the Cancer Genetics Network (CGN) RFA CA-97-004. This TCGC would bring to the CGN extensive expertise in basic and clinical cancer genetics, human and molecular genetics, management of confidential human cancer genetics data, community outreach in human genetics, professional and public education, and psychosocial studies of the impact of cancer genetic counseling and testing. The TCGC will include existing cancer high risk clinical populations, Ashkenazi Jewish populations, registries of familial breast, colon, MEN2, NF1 and other genetic susceptibility syndromes, many followed in studies for decades, patients at high cancer risk participating in screening and early detection studies or chemoprevention trials, and a large database of cancer patients from which to identify high risk family members for potential recruitment to the CGN. The Texas population is diverse in ethnic makeup, and the TCGC includes investigators with proven track records in assessing needs of the Hispanic and African American communities in health care, in providing health education to those communities and their healthcare providers, and in recruiting their participation in familial cancer registries and clinical and research studies. Funding of this application would provide the opportunity for our TCGC to strengthen our within consortium interactions, to contribute our research experience and expertise to the CGN design and implementation, and to utilize our experience and expertise in recruitment of high risk patients to CGN protocols. The long term goal is to contribute to the identification of cancer susceptibility genes, their mechanisms of action, frequency, penetrance, and genetic or environmental risk modifiers, to integrate this information into optimal patient management, and to assess needs and provide education to address the ethical and psychosocial concerns surrounding human cancer genetics.

我们提议成立德克萨斯州癌症遗传学联盟 (TCGC)，以响应癌症遗传学网络 (CGN) RFA CA-97-004。 该 TCGC 将为 CGN 带来基础和临床癌症遗传学、人类和分子遗传学、人类癌症遗传学机密数据管理、人类遗传学社区外展、专业和公共教育以及癌症遗传咨询和检测影响的社会心理研究方面的广泛专业知识。 TCGC 将包括现有的癌症高危临床人群、德系犹太人、家族性乳腺癌、结肠癌、MEN2、NF1 和其他遗传易感综合征的登记，其中许多患者在研究中进行了数十年的跟踪，参与筛查和早期检测研究或化学预防试验的高癌症风险患者，以及一个大型癌症患者数据库，从中识别出可能招募到 CGN 的高风险家庭成员。 德克萨斯州人口的种族构成多种多样，TCGC 的调查人员在评估西班牙裔和非裔美国人社区的医疗保健需求、向这些社区及其医疗保健提供者提供健康教育以及招募他们参与家族癌症登记以及临床和研究方面具有良好的记录。 该申请的资助将为我们的 TCGC 提供机会，以加强我们在联盟内部的互动，为 CGN 设计和实施贡献我们的研究经验和专业知识，并利用我们在招募高风险患者加入 CGN 协议方面的经验和专业知识。 长期目标是有助于识别癌症易感基因、其作用机制、频率、外显率以及遗传或环境风险调节剂，将这些信息整合到最佳患者管理中，并评估需求并提供教育，以解决围绕人类癌症遗传学的伦理和社会心理问题。