Hormones During Weight Loss in Breast Cancer Survivors

乳腺癌幸存者减肥过程中的激素

• 批准号: 6650443
• 负责人: CHERYL L ROCK
• 金额: $ 7.6万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-01 至 2005-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6650443
• 关键词: behavior therapy; bioenergetics; body composition; body physical activity; breast neoplasms; chromatography; clinical research; clinical trials; estrogens; health behavior; hormone binding protein; hormone regulation /control mechanism; human subject; insulinlike growth factor; long term survivor; obesity; patient oriented research; radioimmunoassay; statistics /biometry; weight control; weight loss; women's health

DESCRIPTION (provided by applicant) Overweight or obesity is an established negative prognostic factor in both pre-menopausal and postmenopausal breast cancer, and several mechanisms have been proposed to explain this observation. One possible mechanism relates to the effect of excess adipose tissue on circulating gonadal hormones, because adipose tissue is an important extragonadal source of estrogens from precursor adrenal androgens. Obesity is associated with increased circulating concentrations of estrone and estradiol in postmenopausal women, and it also is associated with decreased levels of sex-hormone binding globulin (SHBG), which increases the bioavailable estrogen fraction Another possible mechanism relates to insulin and insulin-like growth factor (IGF)-I, and the interactions of these factors with adiposity and weight Circulating insulin concentration is highly correlated with degree of adiposity in breast cancer survivors In an ongoing NCI-funded randomized controlled study, we are testing the effect of a multi-component weight reduction program on change in body weight and body composition in overweight and obese breast cancer survivors (n=85), and blood samples are collected from the study participants at baseline, 16 weeks (after the intensive treatment phase), and one year. The intervention incorporates cognitive-behavioral therapy, increased physical activity to promote maintenance of (or increased) lean body mass, diet modification to facilitate an energy imbalance, and strategies to improve body image and self-acceptance. The aims of the proposed small grant project are (1) To conduct laboratory assays of SHBG and serum estrogens, and to examine the effect of the intervention on these hormonal factors, in breast cancer survivors participating in a weight reduction program (compared to women in a wait-list control group), using stored blood samples collected at enrollment and following participation, and (2) To conduct laboratory assays of serum insulin, total IGF-I, free IGF-I, and a key binding protein (IGFBP-3) and to examine the effect of the intervention on these hormonal factors in breast cancer survivors participating in the program (compared to women in a wait-list control group), using stored blood samples collected at enrollment and following participation The measurement of hormonal factors and data analyzed in this project will provide vital information about the responsiveness of these hormonal factors to weight loss and change in body composition in overweight and obese breast cancer survivors Also, the results from this study will provide valuable insight about possible mechanisms by which overweight or obesity influences prognosis in women who have been diagnosed with breast cancer.

描述（由申请人提供） 超重或肥胖是绝经前和绝经后乳腺癌中既定的负预后因素，并且已经提出了几种解释这一观察结果的机制。 一种可能的机制与过量脂肪组织对循环性腺激素的影响有关，因为脂肪组织是前体肾上腺雄激素中雌激素的重要外源性来源。 Obesity is associated with increased circulating concentrations of estrone and estradiol in postmenopausal women, and it also is associated with decreased levels of sex-hormone binding globulin (SHBG), which increases the bioavailable estrogen fraction Another possible mechanism relates to insulin and insulin-like growth factor (IGF)-I, and the interactions of these factors with adiposity and weight Circulating insulin concentration is在正在进行的NCI资助的随机对照研究中，与乳腺癌幸存者的肥胖程度高度相关，我们正在测试一个多组分体重减轻体重计划对超重和肥胖母乳幸存者体重和身体组成变化的影响（n = 85）（n = 85），并在基础上收集了基础研究的血液样本，并在基础上进行了16周的治疗，并经过16周的治疗阶段，并在一定的阶段中进行了艰巨的治疗。 干预措施结合了认知行为疗法，增加体育锻炼以促进（或增加）体重的维持，饮食改善以促进能量失衡以及改善身体形象和自我接受的策略。 提议的小赠款项目的目的是（1）进行SHBG和血清雌激素的实验室测定，并检查干预对这些荷尔蒙因素的影响，在减轻体重的乳腺癌幸存者中（与女性减轻体重的女性相比，与候补名单上的对照组相比），使用在注册和（2）范围内收集的血液样本来启动和（2），并固定了（2），并固定了（2）。 IGF-I和关键结合蛋白（IGFBP-3），并检查干预对这些激素因素在参与该计划的乳腺癌幸存者中的影响（与等待名单对照组的女性相比），使用在招募中收集的储存的血液样本，并在招募中收集的储存的血液样本，并在参与该项目的损失因素和数据分析的范围内的损失因素和数据的测量值均提供了构成，这些因素将在这些项目中进行验证，这些因素构成了范围的范围。超重和肥胖的乳腺癌幸存者中的身体成分也将提供有关可能的机制的宝贵见解，这些机制通过这些机制会影响被诊断为乳腺癌的女性的预后。